Long-term biodistribution study of HPMA- ran -LMA copolymers  in vivo  by means of  131 I-labeling

Wagener, Karolin; Moderegger, Dorothea; Allmeroth, Mareli; Reibel, Achim T.; Krämer, Stefan; Biesalski, Barbara; Bausbacher, Nicole; Zentel, Rudolf; Thews, Oliver; Rösch, Frank

doi:10.1016/j.nucmedbio.2017.12.002

Cited by 6 publications

(3 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…50% RCY after 4 min. 168 Interestingly, biodistribution studies of the two radiohalogenated derivatives showed stark differences in organ uptake after 2 h p.i. Liver uptake of the 131 I-labelled polymer was 5-fold that of the 18 F derivative, and was 12-fold higher in the spleen.…”

Section: Radiolabelling Of Organic Nanomaterialsmentioning

confidence: 99%

See 1 more Smart Citation

Radiolabelling of nanomaterials for medical imaging and therapy

2021

View full text Add to dashboard Cite

show abstract

Section: Radiolabelling Of Organic Nanomaterialsmentioning

confidence: 99%

“…strongly suggesting significant deiodination in vivo. 168 The structures of certain polymers can however enable radioiodination reactions without the need for further modification.…”

Section: Radiolabelling Of Organic Nanomaterialsmentioning

confidence: 99%

Radiolabelling of nanomaterials for medical imaging and therapy

2021

View full text Add to dashboard Cite

show abstract

“…[64] In addition, the establishment of a cooperation with Frank Rösch at the Insitute of Nuclear Chemistry facilitated the use of positron emission tomography (PET) to study the body distribution of the newly prepared nanoobjects directly and, thus, to get a direct feed-back between molecular and supramolecular structures and their body distribution. [65,66] Matthias Herth and Matthias Barz established together the first 18 F-labeling of polymers, which made it finally possible to identify better in vivo structure-property relations. [65] In addition, the link to immunology at the University Medical Center in Mainz made it possible to interact closely with biomedical researchers focusing on the immune system as therapeutic target.…”

Section: How Did This Inspire Rudolf Zentel and Next Generations?mentioning

confidence: 99%

From Self‐Organization to Tumor‐Immune Therapy: How Things Started and How They Evolved

Barz

Nuhn

Hörpel³

et al. 2022

Macromol. Rapid Commun.

Self Cite

View full text Add to dashboard Cite

BackgroundOn a sunny afternoon in summer 2021, Rudolf Zentel and Lutz Nuhn visited Helmut Ringsdorf in Mainz-Gonsenheim, Germany. It was the first time they were able to meet each other again in person after the long-lasting restrictions of the COVID-19 pandemic. While having a cup of coffee and a slice of cake on the garden terrace, Zentel and Ringsdorf looked back on the early days and "how things started and how they evolved". In a lively discussion the participants shared their thoughts on naïve ideas from the old days, how they continued, evolved and extended in the Zentel lab (Figure 1). These ideas were afterwards discussed and co-reflected by former students of the Ringsdorf lab (G. Hörpel, R. Zentel) and the Zentel lab (M. Barz, L.Nuhn). As a result, this perspective article was written, which brings together the individual opinions of the authors as -hopefully -a valuable contribution to Macromolecular Rapid Communication's special issue in honor of Rudolf Zentel upon his retirement. Starting PointThe starting point of the work in the Ringsdorf lab was polymer science in the 60s and 70s of the last century (or even better: "the last millennium", quotation by Ringsdorf). At that time, the beginning of the "plastic era" had just started a few decades previously, everything related to polymers was extremely modern, and research on this topic was well supported by chemical industries. Polymers and plastics entered everyday life as commodity

show abstract

Post‐Polymerization Modifications to Prepare Biomedical Nanocarriers with Varying Internal Structures, their Properties and Impact on Protein Corona Formation

Kockelmann,

Zentel,

Nuhn

2023

Macro Chemistry & Physics

Self Cite

View full text Add to dashboard Cite

The reactive ester approach provides access to various types of drug delivery systems. Either amphiphilic block copolymer micelles with hydrophobic cores can be generated for encapsulation of hydrophobic drugs, or they are (reversibly) crosslinked by polar molecules into nano(hydro)gel particles affording hydrophilic cores and coronas. Beyond short oligonucleotides complexation or covalent drug conjugation inside the core, a surface functionalization with targeting units is further possible to address a large variety of drug delivery scenarios. Interestingly, the reactive ester approach can thereby not only govern the nanocarriers inner structure and surface property, but at the same time also provide strategies to prevent protein corona formation. These features are summarized in this article and underline the concept of reactive ester macromolecules as beneficial tool for assisting in drug delivery.This article is protected by copyright. All rights reserved

show abstract

Long-term biodistribution study of HPMA- ran -LMA copolymers in vivo by means of 131 I-labeling

Cited by 6 publications

References 33 publications

Radiolabelling of nanomaterials for medical imaging and therapy

Radiolabelling of nanomaterials for medical imaging and therapy

From Self‐Organization to Tumor‐Immune Therapy: How Things Started and How They Evolved

Post‐Polymerization Modifications to Prepare Biomedical Nanocarriers with Varying Internal Structures, their Properties and Impact on Protein Corona Formation

Contact Info

Product

Resources

About