Long-term brain and behavioral consequences of early iron deficiency

Georgieff, Michael

doi:10.1111/j.1753-4887.2011.00432.x

Cited by 249 publications

(223 citation statements)

References 60 publications

(154 reference statements)

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“…These infants were reassessed at age 5 years, early adolescence, mid-adolescence, 19 years and 25 years, and the authors conclude that IDA in infancy results in 'substantial loss of human potential' (23)(24)(25)(26)(27) . Abnormalities in dopamine metabolism and myelination have also been identified in animal models (28) .…”

Section: Discussionmentioning

confidence: 99%

Severe iron-deficiency anaemia and feeding practices in young children

Parkin

DeGroot²,

Maguire³

et al. 2015

Public Health Nutr.

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Objectives: Fe-deficiency anaemia (IDA) occurs in 1-2 % of infants in developed countries, peaks at 1-3 years of age and is associated with later cognitive deficits. The objectives of the present study were to describe the characteristics of young children with severe IDA and examine modifiable risk factors in a developedcountry setting. Design: Two prospective samples: a national surveillance programme sample and a regional longitudinal study sample. Setting: Canada, 2009-2011. Subjects: Two samples of young children recruited from community-based healthcare practices: a national sample with severe anaemia (Hb < 80 g/l) due to Fe deficiency and a regional sample with non-anaemic Fe sufficiency. Results: Children with severe IDA (n 201, mean Hb 55·1 g/l) experienced substantial morbidity (including developmental delay, heart failure, cerebral thrombosis) and health-care utilization (including a 42 % hospitalization rate). Compared with children with Fe sufficiency (n 597, mean Hb 122·4 g/l), children with severe IDA consumed a larger volume of cow's milk daily (median 1065 ml v. 500 ml, P < 0·001) and were more likely to be using a bottle during the day (78 % v. 43 %, OR = 6·0; 95 % CI 4·0, 8·9) and also in bed (60 % v. 21 %, OR = 6·5; 95 % CI 4·4, 9·5). Conclusions: Severe IDA is associated with substantial morbidity and may be preventable. Three potentially modifiable feeding practices are associated with IDA: (i) cow's milk consumption greater than 500 ml/d; (ii) daytime bottle use beyond 12 months of age; and (iii) bottle use in bed. These feeding practices should be highlighted in future recommendations for public health and primarycare practitioners.

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Section: Discussionmentioning

confidence: 99%

Severe iron-deficiency anaemia and feeding practices in young children

Parkin

DeGroot²,

Maguire³

et al. 2015

Public Health Nutr.

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“…Demir eksikliği olan farelerde, dopaminerjik aktiviteyi azaltan ilaçlarla tedavi edilen farelerdekine benzer davranışlar olduğu saptanmıştır (Youdim 1985). Demirin, beyin gelişimi ve davranışlar üze-rinde önemli etkisinin olduğunu (Yehuda 1990); demir eksikliğinin erken döneminden itibaren, beyinde, yapısal ve fonksiyonel bir takım anormalliklerin oluştuğunu, dopamin metabolizması ve miyelinizasyonda değişikliklerin meydana geldiğini gösteren çalışma-lara sıklıkla rastlanmaktadır (Georgieff 2011).…”

Section: Demir Eksikliği Ve Santral Sinir Sistemi üZerindeki Etkileriunclassified

Iron Deficiency in Pathophysiology of Attention Deficit Hyperactivity Disorder: A Systematic Review

Percinel¹,

Yazıcı²

2014

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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ÖzetDikkat eksikliği ve hiperaktivite bozukluğu, tıp literatüründe en iyi araştırılmış bozukluklardan biri olmasına rağmen, etiyolojisi halen net olarak açıklığa kavuşturulamamıştır. Dikkat eksikliği ve hiperaktivite bozukluğu'nun küratif şekilde tedavi edilmesi için bozukluk ile ilişkili etmenlerin net olarak aydınlatılması oldukça önemlidir. Literatür incelendiğinde, demir eksikliğinin dikkat eksikliği ve hiperaktivite bozukluğu patofizyolojisi için bir risk faktörü olabileceği belirtilmekle birlikte, konu ile ilgili şu ana kadar yapılan çalışmalarda çelişkili sonuçlar elde edildiği gözlenmektedir. Bu yazıda, dikkat eksikliği ve hiperaktivite bozukluğu patofizyolojisinde etkili olduğu düşünülen demir ve demirle ilişkili parametrelerin kan düzeyleri ile ilgili literatürdeki, çocuk ve ergen yaş grubunda, ülkemizde ve yurt dışında yapılmış konu ile ilgili çalışmaların incelenmesi, genel özelliklerinin derlenmesi ve sonuçlarının sunulması amaçlanmıştır.Anahtar sözcükler: Demir, dikkat eksikliği hiperaktivite bozukluğu, ferritin, patofizyoloji. AbstractAlthough attention deficit and hyperactivity disorder is one of the most studied disorders in medical literature, its etiology has not been completely elucidated. Clarification of the factors associated with attention deficit and hyperactivity disorder is of significance for the curative treatment of the disorder. While literature states that iron deficiency may present a risk factor for the pathophysiology of attention deficit and hyperactivity disorder, the studies made on this subject so far have provided contradictory results. This article aims to analyze the studies of children and adolescents in literature made in Turkey and abroad on the levels of iron and iron-related parameters in blood, which are considered to be effective in the pathophysiology of attention deficit and hyperactivity disorder, compile the general characteristics of those studies and present the results.

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“…Animal data have attributed these effects to neural processes most vulnerable to iron deficiency in early life, including neurotransmitter production, neuronal energy metabolism, and myelination. 1 Recent work in rodents has further implicated epigenetic changes and abnormal gene expression in the brain in the pathophysiology of long-term neurological dysfunction associated with early iron deficiency. 1,2 In addition to impaired brain function, emerging human and animal data have demonstrated other developmental consequences of prenatal iron deficiency, including elevated blood pressure, altered nephron morphology, and an increased risk of iron deficiency during infancy.…”

Section: Introductionmentioning

confidence: 99%

“…1 Recent work in rodents has further implicated epigenetic changes and abnormal gene expression in the brain in the pathophysiology of long-term neurological dysfunction associated with early iron deficiency. 1,2 In addition to impaired brain function, emerging human and animal data have demonstrated other developmental consequences of prenatal iron deficiency, including elevated blood pressure, altered nephron morphology, and an increased risk of iron deficiency during infancy. [3][4][5][6] The identification of gestational windows of organ development most profoundly impacted by iron deficiency further underlines the importance of adequate iron supply throughout fetal life.…”

Section: Introductionmentioning

confidence: 99%