Long term calcium intake and rates of all cause and cardiovascular mortality: community based prospective longitudinal cohort study

Michaëlsson, Karl; Melhus, Håkan; Lemming, Eva Warensjö; Wolk, Alicja; Byberg, Liisa

doi:10.1136/bmj.f228

Cited by 237 publications

(194 citation statements)

References 61 publications

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“…24,25 A more recent study showed that calcium supplementation improves short-term outcomes in intensive care unit patients with hypocalcemia. 26 Thus, further investigations are needed to determine whether calcium-supplementation therapy in ACS patients with low serum calcium could improve their prognosis.…”

Section: Discussionmentioning

confidence: 99%

Admission Serum Calcium Levels Improve the GRACE Risk Score Prediction of Hospital Mortality in Patients With Acute Coronary Syndrome

Yan

Liu

Peng

et al. 2016

Clinical Cardiology

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Background: The Global Registry of Acute Coronary Events (GRACE) risk score has been extensively validated to predict risk during hospitalization in patients with acute coronary syndrome (ACS). Recently, serum calcium has been suggested as an independent predictor for in-hospital mortality in patients with ST-segment elevation myocardial infarction; however, the relationship between the 2 has not been evaluated. Hypothesis: The combination of GRACE risk score and serum calcium could provide better performance in risk prediction. Methods: The study enrolled 2229 consecutive patients with ACS. Independent predictors were identified by a multivariate logistic regression model. The incremental prognostic value added by serum calcium to the GRACE score was evaluated by receiver operating characteristic, net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Area under the curve increased significantly after adding serum calcium to the GRACE score (0.685 vs 0.746; Z = 2.617, P = 0.009). Furthermore, inclusion of serum calcium in the GRACE score enhanced NRI (0.524; P = 0.009) and IDI (0.011; P = 0.003). Conclusions: Lower serum calcium level on admission is a possible indicator of increased risk of in-hospital mortality in ACS patients. Inclusion of serum calcium in the GRACE score may lead to a more accurate prediction of this risk. Large prospective studies are needed to confirm this finding.

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Section: Discussionmentioning

confidence: 99%

Admission Serum Calcium Levels Improve the GRACE Risk Score Prediction of Hospital Mortality in Patients With Acute Coronary Syndrome

Yan

Liu

Peng

et al. 2016

Clinical Cardiology

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“…Because of the long-term consumption patterns of diets containing total calcium amounts greater than 1400 mg per day from foods and supplements, women (not men) are at increased risk of death from all causes, including cardiovascular disease with the exception of stroke [14]. Further investigation of this important relationship is needed, but the suggestion that more calcium, especially from supplements, is better for bone health and possibly other aspects of health is not supported by recent evidence.…”

Section: Calcium Intake and Mortality From All Causesmentioning

confidence: 76%

Relationships of Calcium to Skeletal Health and Potential Adverse Effects

Anderson¹

2016

J Clin Nutr Diet

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“…Según el IOM, la ingesta máxima admisible de calcio no debe superar los 2.500mg/persona/día 5 . En un estudio sobre una cohorte prospectiva de 61.433 mujeres nacidas entre el 1914 y el 1948 de la Swedish mammography cohort 28 , seguidas durante 19 años, se estimó que una ingesta alta de calcio diario por encima de las recomendaciones (mayor de 1.400mg/día) proveniente tanto de la dieta como de suplementos se asociaba con mayor mortalidad media por cualquier causa y por causa cardiovascular, cuando se comparaba con aquellas que realizaban una ingestión entre 600-1.000mg, rango de ingesta que correspondería a un 35% de la población presentada en este estudio.…”

Section: Discussionunclassified

Ingesta insuficiente de calcio en la población adulta de la Comunitat Valenciana

Talamantes

Hernández

Izquierdo

2017

Rev Esp Nutr Hum Diet

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Introducción: El calcio mineral es esencial para la salud ósea a lo largo de toda la vida. Este estudio pretende evaluar la prevalencia de ingesta insuficiente de calcio en adultos de la Comunitat Valenciana. Material y Métodos:Se ha utilizado como fuente de datos la Encuesta de Nutrición de la Comunitat Valenciana 2010-2011, estudio poblacional transversal, que recogió los datos de ingestión de calcio mediante un recordatorio dietético de 24 horas. La muestra final fue de 1.206 sujetos mayores de 18 años (597 hombres y 609 mujeres).Resultados: Se estimó una ingesta media de calcio de 741,4mg/persona/día (DE=334,9), observando en hombres una ingesta de 757,8mg/persona/día (DE=350,0), y en mujeres de 725,3mg/persona/día (DE=319,0). Los resultados de ingesta insuficiente obtenidos según los niveles de los requerimientos medios estimados fue de un 70,6% (IC95%:68,0-73,2), siendo mayor en mujeres 75,4% (IC95%:72,0-78,2) que en hombres 65,7% (IC95%:61,9-69,5). Para los valores de ingestas recomendadas la prevalencia fue de un 83,8% (IC95%:81,7-85,9), siendo significativas las diferencias por sexo (p<0,05). Por grupos de edad la prevalencia estimada fue máxima en los mayores de 70 años en ambos casos, 85,5% (IC95%:80,0-91,0) y 94,3% (IC95%:90,7-97,9) respectivamente.Conclusiones: Se observa la existencia de una prevalencia elevada de ingesta insuficiente de calcio en la población adulta de la Comunitat Valenciana. Se deberían implementar estudios que evaluasen la influencia de estos hallazgos sobre patologías relacionadas (osteoporosis, fractura osteoporótica).

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Long term calcium intake and rates of all cause and cardiovascular mortality: community based prospective longitudinal cohort study

Abstract: Objective To investigate the association between long term intake of dietary and supplemental calcium and death from all causes and cardiovascular disease.

Cited by 237 publications

References 61 publications

Admission Serum Calcium Levels Improve the GRACE Risk Score Prediction of Hospital Mortality in Patients With Acute Coronary Syndrome

Admission Serum Calcium Levels Improve the GRACE Risk Score Prediction of Hospital Mortality in Patients With Acute Coronary Syndrome

Relationships of Calcium to Skeletal Health and Potential Adverse Effects

Ingesta insuficiente de calcio en la población adulta de la Comunitat Valenciana

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