Long-term cardiovascular health in adult cancer survivors

Naaktgeboren, Willeke R; Linschoten, Marijke; Graeff, Alexander de; Rhenen, Anna van; Asselbergs, Folkert W.; Maas, Angela H.E.M.; Teske, Arco J.

doi:10.1016/j.maturitas.2017.05.014

Cited by 17 publications

(17 citation statements)

References 76 publications

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“…Discrepancies with the literature were found as well. No treatment factors were associated with the risk of cardiac health problems, even though the risk of cardiovascular disease is increased by 30% in cancer survivors and was significantly associated with radiotherapy and systemic treatment [7,8,29]. The increased risks for coronary events starts within the five years after adiotherapy, but may continue for up to 20e30 years [8,29].…”

Section: Discussionmentioning

confidence: 99%

Patient-reported health problems and healthcare use after treatment for early-stage breast cancer

et al. 2019

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Background: A clear picture of treatment-related health problems following breast cancer treatment is useful in anticipating the informational and other needs of patients during follow-up. This study aimed to identify treatment-related health problems in breast cancer patients up to five years after diagnosis. Secondly, the use of care associated with these health problems was identified. Methods: 876 surgically-treated female patients diagnosed between 2012 and 2016 with early-stage breast cancer were asked to complete an online survey about their current health problems and use of care. Multivariate logistic regression analyses were applied to determine the effect of patient and treatment characteristics on health problems. Results: 404 patients responded (46%). The median age was 62.0 years (SD:10.9). Apart from breast surgery, patients had been treated with radiotherapy (72%), chemotherapy (49%), antihormonal therapy

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Section: Discussionmentioning

confidence: 99%

Patient-reported health problems and healthcare use after treatment for early-stage breast cancer

et al. 2019

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“…Notably, oncological treatments can affect both cardiomyocytes and endogenous CPC, leading to their senescence and/or apoptosis (Huang et al, 2010 ; Su et al, 2015 ). In this scenario, prompt modulation of the cardiac microenvironment could represent a crucial step to counteract chemotherapy-derived unspecific and noxious side effects and avoid long-term cardiovascular complications in cancer survivors (Hahn et al, 2014 ; Giza et al, 2017 ; Naaktgeboren et al, 2017 ). Indeed, a suitable preventive and complementary treatment during oncological therapy could be represented by the administration of stem cell-based secretome drug formulation via catheter-guided coronary infusion prior to chemotherapy, in order to ensure cardiac-specific delivery without jeopardizing oncological therapy.…”

Section: Healing a Broken Heart: A Main Challenge In Regenerative Medmentioning

confidence: 99%

Cardiac Restoration Stemming From the Placenta Tree: Insights From Fetal and Perinatal Cell Biology

et al. 2018

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Efficient cardiac repair and ultimate regeneration still represents one of the main challenges of modern medicine. Indeed, cardiovascular disease can derive from independent conditions upsetting heart structure and performance: myocardial ischemia and infarction (MI), pharmacological cardiotoxicity, and congenital heart defects, just to name a few. All these disorders have profound consequences on cardiac tissue, inducing the onset of heart failure over time. Since the cure is currently represented by heart transplantation, which is extremely difficult due to the shortage of donors, much effort is being dedicated to developing innovative therapeutic strategies based on stem cell exploitation. Among the broad scenario of stem/progenitor cell subpopulations, fetal and perinatal sources, namely amniotic fluid and term placenta, have gained interest due to their peculiar regenerative capacity, high self-renewal capability, and ease of collection from clinical waste material. In this review, we will provide the state-of-the-art on fetal perinatal stem cells for cardiac repair and regeneration. We will discuss different pathological conditions and the main therapeutic strategies proposed, including cell transplantation, putative paracrine therapy, reprogramming, and tissue engineering approaches.

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“…To meet the growing demand for a specialised interdisciplinary approach for the prevention and management of cardiovascular complications, a new discipline termed cardio-oncology has emerged since the late 1990s [ 4 ]. Cardiovascular toxicity due to chemo- and radiotherapy manifests itself in many other forms beyond myocardial dysfunction including, for example, hypertension, arrhythmias and valvular and coronary artery disease; these forms of toxicity fall outside the scope of this review [ 5 ]. However, the main focus of this overview is on the direct cardiotoxic effects of chemotherapy on cardiomyocyte survival.…”

Section: Introductionmentioning

confidence: 99%

Cardio-oncology: an overview on outpatient management and future developments

et al. 2018

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Recent advances in the early detection and treatment of cancer have led to increasing numbers of cancer survivors worldwide. Nonetheless, despite major improvements in the outcome of these patients, long-term side effects of radio- and chemotherapy affect both patient survival and quality of life, independent of the oncological prognosis. Chemotherapy-related cardiac dysfunction is one of the most notorious short-term side effects of anticancer treatment, occurring in ~10% of patients. Progression to overt heart failure carries a strikingly poor prognosis with a 2-year mortality rate of 60%. Early detection of left ventricular damage by periodic monitoring and prompt initiation of heart failure treatment is key in improving cardiovascular prognosis. To meet the growing demand for a specialised interdisciplinary approach for the prevention and management of cardiovascular complications induced by cancer treatment, a new discipline termed cardio-oncology has evolved. However, an uniform, multidisciplinary approach is currently lacking in the Netherlands. This overview provides an introduction and comprehensive summary of this emerging discipline and offers a practical strategy for the outpatient management of this specific patient population.Electronic supplementary materialThe online version of this article (10.1007/s12471-018-1148-7) contains supplementary material, which is available to authorized users.

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Long-term cardiovascular health in adult cancer survivors

Cited by 17 publications

References 76 publications

Patient-reported health problems and healthcare use after treatment for early-stage breast cancer

Patient-reported health problems and healthcare use after treatment for early-stage breast cancer

Cardiac Restoration Stemming From the Placenta Tree: Insights From Fetal and Perinatal Cell Biology

Cardio-oncology: an overview on outpatient management and future developments

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