Long-term carriage of NDM-1-producing Escherichia coli

Poirel, Laurent; Hervé, Vincent; Hombrouck-Alet, Cécile; Nordmann, Patrice

doi:10.1093/jac/dkr236

Cited by 31 publications

(15 citation statements)

References 7 publications

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“…Interestingly, both faecal and urine specimens from this patient remained positive when the patient was followed up 7 months later, indicating the potential for NDM-positive bacteria to persist at sites of colonization for prolonged periods of time. This has been confirmed in other studies which described gut carriage of NDM-positive Escherichia coli for periods of 13 (Poirel et al, 2011e) and 10 months (D'Andrea et al, 2011), while another report documented carriage of NDM-1-positive K. pneumoniae for more than 7 months (Kim et al, 2012). Secondly, most NDM-positive bacteria reported to date have been isolated from patients who were clinically ill and consequently subjected to microbiological investigation following admission to hospital.…”

Section: Local Spread Of Ndm Following Importationsupporting

confidence: 66%

Global spread of antibiotic resistance: the example of New Delhi metallo-β-lactamase (NDM)-mediated carbapenem resistance

Johnson¹,

Woodford²

2013

Journal of Medical Microbiology

382

286

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The rapidity with which new types of antibiotic resistance can disseminate globally following their initial emergence or recognition is exemplified by the novel carbapenemase New Delhi metallo-blactamase (NDM). The first documented case of infection caused by bacteria producing NDM occurred in 2008, although retrospective analyses of stored cultures have identified the gene encoding this enzyme (bla NDM ) in Enterobacteriaceae isolated in 2006. Since its first description, NDM carbapenemase has been reported from 40 countries worldwide, encompassing all continents except South America and Antarctica. The spread of NDM has a complex epidemiology involving the spread of a variety of species of NDM-positive bacteria and the interstrain, inter-species and inter-genus transmission of diverse plasmids containing bla NDM , with the latter mechanism having played a more prominent role to date. The spread of NDM illustrates that antibiotic resistance is a public health problem that transcends national borders and will require international cooperation between health authorities if it is to be controlled.

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Section: Local Spread Of Ndm Following Importationsupporting

confidence: 66%

Global spread of antibiotic resistance: the example of New Delhi metallo-β-lactamase (NDM)-mediated carbapenem resistance

Johnson¹,

Woodford²

2013

Journal of Medical Microbiology

382

286

View full text Add to dashboard Cite

show abstract

Section: Preventing Transmission: Contact Isolation and Cohortingmentioning

confidence: 99%

“…The mean duration of excretion of CRE associated with gastrointestinal colonization varies significantly between 9.8 days and 19 days, and depends on the carbapenemase enzyme isolated in Enterobacteriaceae. One study found a median carriage time of 3 months [25], but prolonged excretion for up to 1 year has been documented [24,[47][48][49][50]. Schechner et al [24] documented three factors associated with persistent carriage: fluoroquinolone use, intra-facility transfer, and re-admission within 3 months of a culture growing CRE.…”

Section: Preventing Transmission: Contact Isolation and Cohortingmentioning

confidence: 99%

Combating the spread of carbapenemases in Enterobacteriaceae: a battle that infection prevention should not lose

Savard

Perl

2014

Clinical Microbiology and Infection

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The emergence of carbapenemases in Enterobacteriaceae has raised global concern among the scientific, medical and public health communities. Both the CDC and the WHO consider carbapenem-resistant Enterobacteriaceae (CRE) to constitute a significant threat that necessitates immediate action. In this article, we review the challenges faced by laboratory workers, infection prevention specialists and clinicians who are confronted with this emerging infection control issue.

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“…Interestingly, three patients spontaneously decolonized, but one patient (case 4) carried NDMKP for more than 7 months. Prolonged colonization of NDM-1-producing Escherichia coli has been reported in a patient hospitalized for 13 months without exposure to carbapenems or overt infection by such bacteria (20). Prolonged carriage in the gut can be a factor facilitating the spread of NDM-1-producing Enterobacteriaceae.…”

mentioning

confidence: 99%

Nosocomial Clustering of NDM-1-Producing Klebsiella pneumoniae Sequence Type 340 Strains in Four Patients at a South Korean Tertiary Care Hospital

Kim

Yong

et al. 2012

J Clin Microbiol

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cIn November 2010, NDM-1-producing Klebsiella pneumoniae (NDMKP) was identified for the first time in South Korea from four patients with no history of traveling abroad who stayed for 21 to 205 days in a tertiary care hospital. All were sequence type (ST) 340 and had nearly identical XbaI pulsed-field gel electrophoresis (PFGE) patterns. The bla NDM-1 -carrying plasmids were in the IncN group, with sizes ranging from 50 to 200 kb. These findings suggest that NDMKP had already been introduced into South Korea before this clustering was found.

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Long-term carriage of NDM-1-producing Escherichia coli

Cited by 31 publications

References 7 publications

Global spread of antibiotic resistance: the example of New Delhi metallo-β-lactamase (NDM)-mediated carbapenem resistance

Global spread of antibiotic resistance: the example of New Delhi metallo-β-lactamase (NDM)-mediated carbapenem resistance

Combating the spread of carbapenemases in Enterobacteriaceae: a battle that infection prevention should not lose

Nosocomial Clustering of NDM-1-Producing Klebsiella pneumoniae Sequence Type 340 Strains in Four Patients at a South Korean Tertiary Care Hospital

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