Long‐term changes in adipose tissue gene expression following bariatric surgery

Kerr, Alastair G; Andersson, Daniel P.; Rydén, Mikael; Dahlman, Ingrid

doi:10.1111/joim.13066

Cited by 29 publications

(38 citation statements)

References 49 publications

(66 reference statements)

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“…[105][106][107] Some bariatric surgery patients regained weight after weight loss, but the inflammatory factors continued to decrease, indicating that bariatric surgery may have a long-term effect on inflammation control. 108…”

Section: Anti-inflammatory Therapeutic Effect Of Bariatric Surgerymentioning

confidence: 99%

<p>Characterization and Treatment of Inflammation and Insulin Resistance in Obese Adipose Tissue</p>

Song

2020

DMSO

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Adipose tissue is the largest energy storage and protection organ. It is distributed subcutaneously and around the internal organs. It regulates metabolism by storing and releasing fatty acids and secreting adipokines. Excessive nutritional intake results in adipocyte hypertrophy and proliferation, leading to local hypoxia in adipose tissue and changes in the release of adipokines. These lead to recruit of more immune cells into adipose tissue and release of inflammatory signaling factors. Excess free fatty acids and inflammatory factors interfere with intracellular insulin signaling. In this review, we summarize the characteristics of obese adipose tissue and analyze how its inflammation causes insulin resistance. We further discuss the latest clinical research progress on the control of insulin resistance and inflammation resulting from obesity through anti-inflammatory therapy and bariatric surgery. Our review shows that targeted anti-inflammatory therapy is of great significance for obese patients with insulin resistance.

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Section: Anti-inflammatory Therapeutic Effect Of Bariatric Surgerymentioning

confidence: 99%

<p>Characterization and Treatment of Inflammation and Insulin Resistance in Obese Adipose Tissue</p>

Song

2020

DMSO

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“…Genes previously identified as differentially expressed in SAT following bariatric surgery are involved in lipid and energy metabolism, inflammatory and immunological responses, insulin signaling, cell differentiation, oxidative stress regulation and gene transcription [ 27 , 30 ]. A recent study [ 32 ] has also observed long-term effects of RYGB on gene expression in abdominal SAT, with enriched pathways related to lipid metabolism, fat cell differentiation and immune response. Again, most of the studies examining gene expression changes in SAT have been conducted among individuals with obesity who had undergone RYGB or SG, but none had investigated the impact of BPD-DS on the transcriptomic SAT profile [ 27 – 31 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular remodeling of adipose tissue is associated with metabolic recovery after weight loss surgery

et al. 2022

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Background Bariatric surgery is an effective therapy for individuals with severe obesity to achieve sustainable weight loss and to reduce comorbidities. Examining the molecular signature of subcutaneous adipose tissue (SAT) following different types of bariatric surgery may help in gaining further insight into their distinct metabolic impact. Results Subjects undergoing biliopancreatic diversion with duodenal switch (BPD-DS) showed a significantly higher percentage of total weight loss than those undergoing gastric bypass or sleeve gastrectomy (RYGB + SG) (41.7 ± 4.6 vs 28.2 ± 6.8%; p = 0.00005). Individuals losing more weight were also significantly more prone to achieve both type 2 diabetes and dyslipidemia remission (OR = 0.75; 95%CI = 0.51–0.91; p = 0.03). Whole transcriptome and methylome profiling showed that bariatric surgery induced a profound molecular remodeling of SAT at 12 months postoperative, mainly through gene down-regulation and hypermethylation. The extent of changes observed was greater following BPD-DS, with 61.1% and 49.8% of up- and down-regulated genes, as well as 85.7% and 70.4% of hyper- and hypomethylated genes being exclusive to this procedure, and mostly associated with a marked decrease of immune and inflammatory responses. Weight loss was strongly associated with genes being simultaneously differentially expressed and methylated in BPD-DS, with the strongest association being observed for GPD1L (r2 = 0.83; p = 1.4 × 10–6). Conclusions Present findings point to the greater SAT molecular remodeling following BPD-DS as potentially linked with higher metabolic remission rates. These results will contribute to a better understanding of the metabolic pathways involved in the response to bariatric surgery and will eventually lead to the development of gene targets for the treatment of obesity. Trial registration ClinicalTrials.gov NCT02390973.

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“…The 7,729 early and maintained DMS were compared to 4,128 genes reported to show early response or continual change in expression in one direction after bariatric surgery in the same cohort 8 . This identified 1,259 differentially expressed genes with DMS (Supp.…”

Section: Resultsmentioning

confidence: 99%

“…Changes in peripheral organs are also likely involved in the regulation of metabolism. For example, bariatric surgery results in early and continued decrease in SAT inflammatory gene expression and release of cytokines as well as development of a hyperplastic adipose tissue (many but small fat cells), which is considered to be a benign adipose morphology 8 . The present study suggests that improvement of fat cell lipogenesis is an additional long-term beneficial effect of bariatric surgery.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Long-term improvement of adipocyte insulin action during body weight relapse after bariatric surgery: a longitudinal cohort study

Andersson

Tseng

Arner

et al. 2022

Surgery for Obesity and Related Diseases

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Long‐term changes in adipose tissue gene expression following bariatric surgery

Abstract: Long-term changes in adipose tissue gene expression following bariatric surgery (Original Article).

Cited by 29 publications

References 49 publications

<p>Characterization and Treatment of Inflammation and Insulin Resistance in Obese Adipose Tissue</p>

<p>Characterization and Treatment of Inflammation and Insulin Resistance in Obese Adipose Tissue</p>

Molecular remodeling of adipose tissue is associated with metabolic recovery after weight loss surgery

Long-term improvement of adipocyte insulin action during body weight relapse after bariatric surgery: a longitudinal cohort study

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