Long-Term Changes in Collagen Formation Expressed by Serum Carboxyterminal Propeptide of Type-I Procollagen and Relation to Left Ventricular Function after Acute Myocardial Infarction

Abstract

The purpose of this study was to investigate the long-term sequential changes in serum levels of the carboxyterminal propeptide of type-I procollagen (s-PICP), which is a marker of type-I collagen synthesis, and to assess its clinical value in relation to left ventricular (LV) function and prognosis following acute myocardial infarction (AMI). Forty-eight consecutive patients with their first AMI and 15 control subjects were studied. Patients with AMI were stratified according to the changes in s-PICP levels between days 1 and 90 (ΔPICP) and divided into group I with ≤16.0 µg/l or group II with >16.0 µg/l. Patients in group II were characterized by LV dilatation, no improvement in ejection fraction and development of impaired diastolic filling from day 1 to 360, findings which were in contrast to group I. Cox regression analysis identified changes in s-PICP of >16.0 µg/l as an independent predictor of cardiac death or heart failure during follow-up. In conclusion, ΔPICP relates to long-term changes in LV function and size, and provides prognostic information following AMI.

Extracellular Cardiac Matrix Biomarkers in Patients With Acute Myocardial Infarction Complicated by Left Ventricular Dysfunction and Heart Failure

“…10 -16 They remained high for periods of up to 1 year. 14 Our results are supported by experimental work in which increases in types I and III procollagen mRNA in both infarcted and noninfarcted myocardium, followed by an increased collagen deposition, were reported as early as day 2 and peaked at day 14. 17,18 Of note, our study enrolled only patients after AMI with LVSD and predominantly with HF.…”

Fibrosis-Related Biomarkers and Incident Cardiovascular Disease in Older Adults

“…6 In prospective studies, TGF-β and PIIINP have been inconsistently associated with incident CVD events. 5, 7–12 Most of these studies have been conducted among hospitalized patients or patients with pre-existing CVD. A few studies have been conducted among community-living individuals, 9, 11, 13 but sample sizes have been modest, with the largest to date examining 922 individuals over a mean of 9.9 years.…”

Influence of Primary Coronary Intervention on Myocardial Collagen Metabolism and Left Ventricle Remodeling Predicted by Collagen Metabolism Markers

“…Increases in collagen I and collagen III synthesis were observed within the first 48 hours after MI. This process might persist even 1 month after MI, 5) however, collagen synthesis was much less pronounced in patients after successful PCI compared to patients where this treatment was unsuccessful. Therefore, unsuccessful PCI may significantly elevate the concentration of collagen in the human myocardium and accelerate remodeling of cardiac ECM after MI.…”