Long-term changes in serum cholesterol level does not influence the progression of coronary calcification

Tenenbaum, Alexander; Shemesh, Joseph; Koren‐Morag, Nira; Fisman, Enrique Z.; Adler, Yehuda; Goldenberg, Ilan; Tanné, David; Hay, Ilan; Schwammenthal, Ehud; Motro, Michael

doi:10.1016/j.ijcard.2010.03.001

Cited by 17 publications

(18 citation statements)

References 47 publications

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“…However, more and more recent evidence demonstrates that arterial calcification (AC) is also an important and independent risk factor for cardiovascular mortality in CKD (92,93). Interestingly, even if the blood lipid was effectively managed through blood lipid-lowering drugs, the progression of AC could not be influenced (52,98). AC was once regarded as a passive process in CKD.…”

mentioning

confidence: 99%

MICS, an easily ignored contributor to arterial calcification in CKD patients

Zhang

Gao

Chen

et al. 2016

American Journal of Physiology-Renal Physiology

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In chronic kidney disease (CKD), simultaneous mineral and skeleton changes are prevalent, known as CKD-mineral bone disorder (CKD-MBD). Arterial calcification (AC) is a clinically important complication of CKD-MBD. It can increase arterial stiffness, which leads to severe cardiovascular events. However, current treatments have little effect on regression of AC, as its mechanisms are still unclear. There are multiple risk factors of AC, among which Malnutrition-Inflammation Complex Syndrome (MICS) is a new and crucial one. MICS, a combined syndrome of malnutrition and inflammation, generally begins at the early stage of CKD and becomes obvious in end-stage renal disease (ESRD). It was linked to reverse epidemiology and associated with increased cardiovascular mortality in ESRD patients. Recent data suggest that MICS can trigger CKD-MBD and accelerate the course of AC. In this present review, we summarize the recent understanding about the aggravating effects of MICS on AC and discuss the possible underlying mechanisms. A series of findings indicate that targeting MICS will provide a potential strategy for treating AC in CKD.

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confidence: 99%

MICS, an easily ignored contributor to arterial calcification in CKD patients

Zhang

Gao

Chen

et al. 2016

American Journal of Physiology-Renal Physiology

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“…Those more likely to have a family member present include patients with a low level of health literacy, patients with chronic diseases, older patients, and women (32,33). We find that Patients accompanied by women were more frequently male, with fewer ENT diseases, and took more drugs from the musculoskeletal group than male patients (Table 2), which can be globally interpreted as that there was no clinically significant differences between patients according to the gender of her or his companion.…”

Section: Discussionmentioning

confidence: 69%

The social and health gender differences in patients companion in the family medicine consultation

Turabián¹,

Minier-Rodriguez²,

Moreno-Ruiz³

et al. 2017

Curr Res Integr Med

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A ll over the world women are the predominant providers of informal care for family members with chronic medical conditions or disabilities, including the elderly and adults with mental illnesses. It has been suggested that there are several societal and cultural demands on women to adopt the role of a family-caregiver (1). So, spouses often serve as the primary caregivers to their ill or disabled partners (2).The domain of health includes the entire range of issues which touch on illness, sickness, disease, wellness, as well as those activities of preventing, diagnosing, healing, caring and curing. Thus, questions about women's participation in this domain profound and immediate concern to women, and involve roles and selves. Women have domestic activities which sustain, literally and symbolically, the way of life. As the providers of health, women are responsible for securing the domestic conditions necessary for the maintenance of health and for recovery from sickness. Women also serve as mediators of outside services. Their responsibilities with the domestic health service unavoidably bring them into contact with professional health service, among them the family doctor (3).In practice, a third person (companion) frequently accompanies a patient during medical encounter. There is a high prevalence of the presence of a companion, who is in almost one of every 4 visits served in Family Medicine. Companions of the patients in the medical office are usually family members in near 100% of cases (4-9).The major results of existing studies suggest that the regular presences of companions of the patients in consultations are often perceived as helpful. Accompaniment to medical visits is associated with better self-care maintenance and management, and this effect may be mediated through satisfaction with provider communication (10). Also, companions provide company, emotional support, and they have a role in mobility and decision making of the patients (11,12). However, their participation often poses challenges (13).Despite all the above, the reports, reviews or investigations about the gender OBJECTIVES:The purpose of this study is to describe gender differences in patient's companion, and their characteristics, in family medicine consultations. METHODS:A descriptive and prospective study in a family medicine office (Toledo, Spain) was carried out. For each patient and companion, the following variables were collected: age, gender, chronic illness, chief complaint, medications taken, social class, request for additional tests, kinship, social status and availability of companion. The bivariate comparisons were performed using the test of Chi squared, the Student t test, and the MannWhitney test.RESULTS: 104 companions to the patient in the family medicine office were obtained. Of these, 65 (62.5%) were female, and 39 (37.5%) male.In the female companions with regard to the male companions: there were 69% in the group of 40-64 years old vs. 49% (p = 0.02); were wife (34%) vs. husband (56%) (P=0.001); were unskilled...

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“…In the recent years, cellular pathways regarding the regulation of myocardial O2 and energy metabolism (utilization and production) have gained particular importance as alternative or adjunctive targets for the management of myocardial ischemia. Based on this concept, a variety of agents, namely cellular anti-ischemics including trimetazidine (TMZ) (an inhibitor of free fatty acid (FFA) oxidation) has been used as complementary antiischemic options due to their potential beneficial effects on myocardial energy metabolism along with a consequent reduction in total myocardial ischemic burden as previously demonstrated in diabetic patients with coronary artery disease (CAD) [2]. Interestingly, allopurinol (xanthine oxidase inhibitor),an antioxidant agent primarily used in gout disease, was also demonstrated to be of therapeutic value in patients with stable angina pectoris (SAP) due to its cellular antiischemic effects along with its potential to improve endothelial function [3].…”

Section: Referencesmentioning

confidence: 99%

“…We greatly appreciated the interesting and stimulating discussion letter by Ravnskov [1] commenting on our recent study which concluded that both cholesterol changes over time and presence of lipid lowering therapy do not seem to have any measurable effect on the rate of progression of coronary calcification when assessed by computerized tomography (CT) [2]. We believe that the process of calcification may spread out in a different manner than the overall development of atherosclerosis.…”

mentioning

confidence: 99%