Long-term clinicopathological prognosis on 609 cases after gastrectomy: A 10-year follow up single-institutional retrospective analysis

Abstract

Objective: This retrospective study focused on relevant factors about gastric cancer patients who underwent gastrectomy after 10 years, which showed great significance of prolonging survival time of gastric cancer patients. Methods: 609 gastric cancer patients after surgery were recruited from January, 2005 to December, 2007. They were perfectly followed and their clinicopathological data were collected. Univariate analysis was performed using Log-rank test in order to compare survival rates between or among groups. The outcomes with statistical significance (P<0.05) were screened out. Cox regression model was employed for survival multivariate analysis. Forward stepwise LR analysis was used to screen the factors influencing survival qualities of relevant patients after surgery. Results: Univariate analysis indicated that prognosis was correlated with age, pT stage, pN stage, pM stage, tumor size, location, type of gastrectomy, degree of differentiation, vascular invasion, nerve invasion, radical treatment, chemotherapy, radiotherapy, pTNM stage and BMI (P＜0.05). Multivariate analysis showed that pT stage, pN stage, pM stage, degree of differentiation, vascular invasion, nerve invasion, radical treatment, chemotherapy, radiotherapy, pTNM stage were independent prognostic factors of GC patients (P＜0.05). Conclusions: The 10-year survival rates of gastric cancer patients are primarily determined by tumor progression. Appropriate treatment can improve prognosis of patients. Early diagnosis of gastric cancer and prompt implementation of radical surgery and adjuvant chemotherapy are essential for increasing survival rates. This study provides a promising direction for future basic researches.