2014
DOI: 10.1017/s1355617714000174
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Long-Term Cognitive Correlates of Traumatic Brain Injury across Adulthood and Interactions with APOE Genotype, Sex, and Age Cohorts

Abstract: Objective: There is continuing debate about long-term effects of brain injury. We examined a

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Cited by 43 publications
(30 citation statements)
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“…Similarly, TBI predisposes to AD (Fleminger et al, 2003). As with AD and PD, post-stroke syndromes and TBI also manifest a predisposition to be more severe in APOE4 individuals (Eramudugolla et al, 2014;Das et al, 2016). Another set of observations transgressing these traditional clinical divides concerns the ability of SB623 stem cells, which manifest an anti-TNF activity (see below) being efficacious for the PD model generated by injecting methylphenyltetrahydropyridine (MPTP) (Tate et al, 2017) and in post-stroke patients (Steinberg et al, 2016b).…”
Section: Insights From the Basic Similarities Of Certain Neurodegenermentioning
confidence: 99%
“…Similarly, TBI predisposes to AD (Fleminger et al, 2003). As with AD and PD, post-stroke syndromes and TBI also manifest a predisposition to be more severe in APOE4 individuals (Eramudugolla et al, 2014;Das et al, 2016). Another set of observations transgressing these traditional clinical divides concerns the ability of SB623 stem cells, which manifest an anti-TNF activity (see below) being efficacious for the PD model generated by injecting methylphenyltetrahydropyridine (MPTP) (Tate et al, 2017) and in post-stroke patients (Steinberg et al, 2016b).…”
Section: Insights From the Basic Similarities Of Certain Neurodegenermentioning
confidence: 99%
“…People sustaining TBI are more than four times more likely to develop dementia at a later stage than people without TBI. Genetic background of B‐APP , apolipoprotein E (ApoE), presenilin (PS), and neprilysin (NEP) genes are associated with exacerbation of neurodegenerative processes after TBI …”
Section: Traumatic Brain Injurymentioning
confidence: 99%
“…Genetic background of B-APP, apolipoprotein E (ApoE), presenilin (PS), and neprilysin (NEP) genes are associated with exacerbation of neurodegenerative processes after TBI. 29 Alzheimer's dementia is characterized by the presence of extracellular amyloid beta (AB) senile plaques and intracellular neurofibrillary tangles (NFTs). Senile plaques are formed of aggregated AB, whereas…”
Section: Traumatic Brain Injurymentioning
confidence: 99%
“…Researchers have examined genotype as well as clinical presentation and medical history. The apolipoprotein (APOE) ε4 allele, previously implicated as a risk factor for late-onset Alzheimer disease (LOAD), has been shown to increase the risk of a poor recovery and worse outcome after TBI (Teasdale et al 1997;Eramudugolla et al 2014;Liberman et al 2002). Studies indicate a relationship between APOE ε4 genotype and longer recovery time (Friedman et al 1999), worse performance on neurocognitive tests at 3 and 6 weeks post TBI (Liberman et al 2002) and severity of cognitive deficit (Jordan et al 1997;Kutner et al 2000).…”
Section: Introductionmentioning
confidence: 99%