Long-Term Cognitive Impact of Anticholinergic Medications in Older Adults

Bottiggi, Kara A.; Salazar, Juan Carlos; Yu, Lei; Caban‐Holt, Allison; Mendiondo, Marta S.; Schmitt, Frederick A.; Ryan, Melody

doi:10.1097/01.jgp.0000224619.87681.71

Cited by 86 publications

(68 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the HC group, a significant association between anticholinergic drug use and slower psychomotor speed supported the findings of 2 previous studies [8,9]. We also observed a significant relationship between anticholinergic drug use and impaired executive functioning (Stroop incongruent trial), consistent with 2 prior studies [6,9].…”

Section: Discussionsupporting

confidence: 82%

“…Our findings, similar to previous studies [6,7,8,9,18], demonstrate negative impacts of anticholinergic drugs on cognitive functioning in older people. In the HC group, a significant association between anticholinergic drug use and slower psychomotor speed supported the findings of 2 previous studies [8,9].…”

Section: Discussionsupporting

confidence: 81%

“…However, research examining the effect of anticholinergic drug use on cognition has produced inconsistent results. In some studies anticholinergic medications have been observed to have no effect on executive function [7,8], language skills [8], immediate recall and implicit memory [7], ability to learn and remember new information, and Mini-Mental State Examination (MMSE) scores [9]. …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Anticholinergic Drugs on Cognitive Function in Older Australians: Results from the AIBL Study

Sittironnarit

Ames

Bush

et al. 2011

Dement Geriatr Cogn Disord

129

105

View full text Add to dashboard Cite

Background/Aims: The nature and extent of adverse cognitive effects due to the prescription of anticholinergic drugs in older people with and without dementia is unclear. Methods: We calculated the anticholinergic load (ACL) of medications taken by participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing, a cohort of 211 Alzheimer’s disease (AD) patients, 133 mild cognitive impairment (MCI) patients and 768 healthy controls (HC) all aged over 60 years. The association between ACL and cognitive function was examined for each diagnostic group (HC, MCI, AD). Results: A high ACL within the HC group was associated with significantly slower response speeds for the Stroop color and incongruent trials. No other significant relationships between ACL and cognition were noted. Conclusion: In this large cohort, prescribed anticholinergic drugs appeared to have modest effects upon psychomotor speed and executive function, but not on other areas of cognition in healthy older adults.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Anticholinergic Drugs on Cognitive Function in Older Australians: Results from the AIBL Study

Sittironnarit

Ames

Bush

et al. 2011

Dement Geriatr Cogn Disord

129

105

View full text Add to dashboard Cite

show abstract

“…However another study reported no cross-sectional associations with Trails A and B (Bottiggi et al, 2006). Our findings are in contrast with studies that found anticholinergic use was cross-sectionally associated with memory and processing speed (LechevallierMichel et al, 2005b;Ancelin et al, 2006) and with cognitive decline over time (Bottiggi et al, 2006).…”

Section: Discussioncontrasting

confidence: 81%

“…The Health Aging and Body composition study (n ¼ 3075) reported that use of medications with anticholinergic properties was associated with poorer performance on the digit symbol substitution test (Hilmer et al, 2007). The BRAiNS study (n ¼ 592) found that elderly volunteers' use of medications with anticholinergic properties did not have any cross-sectional associations with cognitive function, but baseline use was associated with greater decline over six years on attention and speed, though not MMSE scores or verbal memory (Bottiggi et al, 2006).…”

Section: Introductionmentioning

confidence: 98%