Long-Term Cognitive Sequelae After Pediatric Brain Tumor Related to Medical Risk Factors, Age, and Sex

Olsson, Ingrid Tonning; Perrin, Sean; Lundgren, Johan; Hjorth, Lars; Johanson, Aki

doi:10.1016/j.pediatrneurol.2014.06.011

Cited by 86 publications

(63 citation statements)

References 34 publications

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“…15,16 However, the ability to deliver more focused conformal radiation to young children with acceptable neurocognitive outcomes is also supported by the literature, and this should be highly considered for young children with localized ATRTs. 15,16 However, the ability to deliver more focused conformal radiation to young children with acceptable neurocognitive outcomes is also supported by the literature, and this should be highly considered for young children with localized ATRTs.…”

Section: Discussionmentioning

confidence: 95%

Assessment of the treatment approach and survival outcomes in a modern cohort of patients with atypical teratoid rhabdoid tumors using the National Cancer Database

Fischer‐Valuck

Chen

Srivastava

et al. 2016

Cancer

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Background: Primary gliosarcoma is a rare malignant brain tumor with dismal prognosis. Previous reports are limited to case reports and small retrospective case series. Objective: To evaluate treatment and survival outcomes in a large cohort of primary gliosarcoma patients treated in the United States. Results: 1622 patients met the inclusion criterion. Median age was 63 years. The 3-year OS rate for the entire cohort was 11.9%. Patients aged 18 to 60 years were significantly more likely to receive trimodality therapy (defined as the use of surgery, radiotherapy [RT] and chemotherapy [CT]) than patients older than 60 (68.1% vs. 56.7%, p < 0.001). The utilization of trimodality therapy significantly increased during the study period (57.5% in 2004-2008 vs. 65.1% in 2009-2013; p = 0.002). On multivariate Cox regression analysis, GTR, surgery followed by RT and the use of trimodality therapy were associated with longer OS, while older age, Charlson-Deyo score ≥ 1 and multi-focal tumor were associated with shorter OS. The use of trimodality therapy was consistently associated with longer OS in subgroup analyses based on age and extent of resection. Materials and Methods: The National Cancer Database was used to identify all primary gliosarcoma patients aged 18 to 90 years who were diagnosed between 2004 and 2013. Overall survival (OS) was evaluated by Kaplan-Meir analysis, univariate and multivariate Cox proportional hazard regression analysis. Conclusions: The use of trimodality therapy significantly increased during the study period and was associated with improved outcomes regardless of age and extent of resection.

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Section: Discussionmentioning

confidence: 95%

Assessment of the treatment approach and survival outcomes in a modern cohort of patients with atypical teratoid rhabdoid tumors using the National Cancer Database

Fischer‐Valuck

Chen

Srivastava

et al. 2016

Cancer

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“…Other areas of executive function are also susceptible to disruptions and impairments following treatment for brain tumors, including strategic planning functions and cognitive flexibility (Maddrey et al, 2005; Spiegler et al, 2004). Tumor size has been documented to be associated with greater cognitive impairments, including global executive dysfunction in pediatric brain tumor survivors (Tonning Olsson et al, 2014). Compared to survivors of pediatric leukemia, brain tumor survivors show more global and higher level executive function problems (Winter et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Executive functioning profiles from the BRIEF across pediatric medical disorders: Age and diagnosis factors

Krivitzky

Walsh

Fisher

et al. 2015

Child Neuropsychology

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Objective To compare Executive Functioning (EF) profiles across several pediatric medical conditions and explored the influence of age of diagnosis and evaluation. Methods This was a retrospective, cross sectional study of 734 children ages 5-18 across five medical groups [brain tumor, leukemia (ALL), epilepsy (EPI), Neurofibromatosis Type 1 (NF1), and Ornithine Transcarbamylase Deficiency (OTC-D)], ADHD controls, and matched healthy controls. We compared groups across the subscales of a parent completed Behavior Rating Inventory of Executive Functioning (BRIEF) using MANOVA. Separate MANOVAs were conducted to look at age factors. Results The ADHD group differed from all other groups and had the highest level of reported EF problems. The NF1 and OTC-D groups differed significantly from the healthy comparison group for overall EF problems, while the EPI and cancer groups did not. Working Memory was the most elevated subscale across medical groups, followed by Plan/Organize. Children with medical disorders were two to four times as likely as healthy controls to have clinically significant problems in several EF domains. There was a main effect for age at diagnosis and age at evaluation.. Conclusions A subset of children with medical disorders were found to have parent reported EF difficulties, with particular vulnerability noted in working memory and organizational/planning skills. This has relevance for the development of interventions that may be helpful across disorders. Children with particular diagnoses and earlier age of diagnosis and evaluation had greater reported EF problems.

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“…Assessing and monitoring cognitive function for children at risk for cognitive decrements due to neurological conditions (e.g., childhood brain tumors) or neurotoxic treatments are important [1, 2], which is traditionally evaluated by neuropsychological testing. Unfortunately, such testing is not always feasible due to its length, costs, practice effects, or limited manpower in clinical settings.…”

Section: Introductionmentioning

confidence: 99%

Evaluating Psychometric Properties of the Spanish-version of the Pediatric Functional Assessment of Chronic Illness Therapy-Perceived Cognitive Function (pedsFACIT-PCF)

et al. 2015

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Purpose The pediatric Functional Assessment of Chronic Illness Therapy-Perceived Cognitive Function (pedsFACIT-PCF) is a 13-item short-form derived from the pediatric Perceived Cognitive Function item bank (pedsPCF), which was developed to measure children’s daily cognitive behaviors and was validated on the US general population and children with cancer. This study evaluated the psychometric properties of Spanish language pedsFACIT-PCF and the measurement equivalence between Spanish and English versions. Methods pedsFACIT-PCF items were translated into Spanish using a standard iterative methodology. A total of 1358 English- and 604 Spanish-speaking children aged 8–17 years who completed English and Spanish versions of pedsFACIT-PCF, respectively, were administered through an Internet survey company. Unidimensionality was evaluated using confirmatory factor analysis. Item responses were modeled using item response theory. The presence and impact of differential item functioning (DIF) were evaluated using ordinal logistic regression. Results Unidimensionality of the pedsFACIT-PCF was supported. One of the 13 items demonstrated statistically significant DIF by language; however, impacts of language DIF on both individual scores and at the test level were negligible. No Spanish items showed DIF with respect to age and gender. Conclusions The 13-item pedsFACIT-PCF demonstrated stable measurement properties on language, gender and age and can be used for future trials.

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Long-Term Cognitive Sequelae After Pediatric Brain Tumor Related to Medical Risk Factors, Age, and Sex

Cited by 86 publications

References 34 publications

Assessment of the treatment approach and survival outcomes in a modern cohort of patients with atypical teratoid rhabdoid tumors using the National Cancer Database

Assessment of the treatment approach and survival outcomes in a modern cohort of patients with atypical teratoid rhabdoid tumors using the National Cancer Database

Executive functioning profiles from the BRIEF across pediatric medical disorders: Age and diagnosis factors

Evaluating Psychometric Properties of the Spanish-version of the Pediatric Functional Assessment of Chronic Illness Therapy-Perceived Cognitive Function (pedsFACIT-PCF)

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