Long‐term Colonization of a <i>Lactobacillus plantarum</i> Synbiotic Preparation in the Neonatal Gut

Panigrahi, Pinaki; Parida, Sailajanandan; Pradhan, Lingaraj; Mohapatra, Shubhranshu S; Misra, Pravas R.; Johnson, Judith A.; Chaudhry, Rama; Taylor, Sarah; Hansen, Nellie I.; Gewolb, Ira H

doi:10.1097/mpg.0b013e31815a5f2c

Cited by 74 publications

(70 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…85 A double-blind randomized controlled trial (RCT) with 31 infants showed that L. plantarum , when administered in a synbiotic combination with oligofructose, successfully colonized 100% of infants at 2 months and 32% at 6 months after a 1-week administration. 86 Another recent RCT examined 925 infants at risk for allergic disorders and found that daily administration of a 4-species probiotics mixture, combined with GOS, reduced antibiotic prescriptions and respiratory infections. 87 These studies suggest that effective combinations of probiotics and prebiotics result in sustainable changes in microbial composition and benefits for the human host.…”

Section: Lessons From Prebiotics and Synbioticsmentioning

confidence: 99%

Targeting the Human Microbiome With Antibiotics, Probiotics, and Prebiotics: Gastroenterology Enters the Metagenomics Era

2009

View full text Add to dashboard Cite

Studies of metagenomics and the human microbiome will tremendously expand our knowledge of the composition of microbial communities in the human body. As our understanding of microbial variation and corresponding genetic parameters is refined, this information can be applied to rational remodeling or “tailoring” of human-associated microbial communities and their associated functions. Physiologic features such as the development of innate and adaptive immunity, relative susceptibilities to infections, immune tolerance, bioavailability of nutrients, and intestinal barrier function may be modified by changing the composition and functions of the microbial communities. The specialty of gastroenterology will be affected profoundly by the ability to modify the gastrointestinal microbiota through the rational deployment of antibiotics, probiotics, and prebiotics. Antibiotics might be used to remove or suppress undesirable components of the human microbiome. Probiotics can introduce missing microbial components with known beneficial functions for the human host. Prebiotics can enhance the proliferation of beneficial microbes or probiotics, to maximize sustainable changes in the human microbiome. Combinations of these approaches might provide synergistic and effective therapies for specific disorders. The human microbiome could be manipulated by such “smart” strategies to prevent and treat acute gastroenteritis, antibiotic-associated diarrhea and colitis, inflammatory bowel disease, irritable bowel syndrome, necrotizing enterocolitis, and a variety of other disorders.

show abstract

Section: Lessons From Prebiotics and Synbioticsmentioning

confidence: 99%

Targeting the Human Microbiome With Antibiotics, Probiotics, and Prebiotics: Gastroenterology Enters the Metagenomics Era

2009

View full text Add to dashboard Cite

show abstract

“…Die Ergebnisse der Anwendung von (unterschiedlichen) Probiotika zur Präventi-on der NEC auf der Basis aktueller Daten lassen sich folgendermaßen skizzieren [7,15,16,18,32,35,39,44,48,57]: …”

Section: Resümeeunclassified

Probiotika in der Kindergastroenterologie

Radkë

2010

Monatsschr Kinderheilkd

View full text Add to dashboard Cite

“…"Prebiotics" are 'non-digestible food ingredients that beneficially affect the host by selectively stimulating the growth and/or activity of one or a limited number of bacteria in the colon, thus having the potential to improve host health 4 . Thus prebiotics enhance the survival of endogenous probiotic organisms 5,6 . The food ingredients most likely to meet these criteria at present are oligosaccharides (including inulin) and their derivatives, the fructo-oligosaccharides 7,8 .…”

Section: Prebiotics and Symbioticsmentioning

confidence: 99%