Long‐term combination therapy of ustekinumab and dapsone in a patient with psoriasis and dermatitis herpetiformis <scp>D</scp>uhring

Gkalpakiotis, Spyridon; Arenberger, Petr; Sticová, Eva; Sefrnova, Petra; Arenbergerová, Monika

doi:10.1111/j.1346-8138.2012.01630.x

Cited by 1 publication

(2 citation statements)

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“…DH is a common extraintestinal manifestation of CD, with a prevalence ratio of 1:8 [6]. To our knowledge, the coexistence of DH and chronic plaque psoriasis is rare and has only been described in case reports [2][3][4]. The current literature, however, supports an association between psoriasis and CD, which would explain a possible connection between psoriasis and DH.…”

Section: Discussionmentioning

confidence: 84%

“…Chronic plaque psoriasis is frequently complicated by autoimmune bullous diseases such as pemphigoid and pemphigus [1]. To the best of our knowledge, the coexistence of psoriasis and other immunobullous eruptions such as dermatitis herpetiformis (DH) is rare, and has only been described in anecdotal reports [2][3][4]. DH is an autoimmune bullous disease that has been linked to celiac disease (CD), a gluten-sensitive enteropathy.…”

Section: Introductionmentioning

confidence: 99%

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Development of Dermatitis Herpetiformis in Chronic Plaque Psoriasis

2021

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Chronic plaque psoriasis is often associated with autoimmune bullous diseases. Dermatitis herpetiformis (DH) is a rare immunobullous disease that has been linked to celiac disease (CD). To our knowledge, the coexistence of psoriasis and DH is uncommon, and has only been described in anecdotal reports. We report a case of chronic plaque psoriasis complicated by DH in a 60-year-old patient with no known history of CD or associated symptoms. In our patient, DH presented atypically as multiple vesicles along the edges of psoriatic plaques located on the back and hips, and as vesiculobullous eruptions on the fingers. The patient was successfully treated with a combination of dapsone and a gluten-free diet for DH, and secukinumab for psoriasis. This case highlights the importance of screening for CD in patients with psoriasis, as well as other concomitant autoimmune diseases. A gluten-free diet should be trialled in psoriatic patients with positive CD serology.

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