Long-term complications and risk of other serious infections following invasive Haemophilus influenzae serotype b disease in vaccinated children

Ladhani, Shamez; Heath, Paul T; Aibara, Rashna J; Ramsay, Mary; Mpe., Slack; Hibberd, Martin L.; Pollard, Andrew J.; Moxon, E. Richard; Booy, Robert

doi:10.1016/j.vaccine.2009.12.057

Cited by 8 publications

(1 citation statement)

References 26 publications

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“…Major sequelae of childhood meningitis have been studied extensively, which in case of bacterial meningitis includes, permanent neurologic disability, sensory and motor impairment, intellectual disability, or loss of a limb (9-14). However, with improved antimicrobial therapy serious complications from early-life meningitis are increasingly less common in the Western countries (13).…”

Section: Introductionmentioning

confidence: 99%

A population-based prospective birth cohort study of childhood neurocognitive and psychological functioning in healthy survivors of early life meningitis

Khandaker¹,

Štochl²,

Zammit³

et al. 2015

Annals of Epidemiology

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Section: Introductionmentioning

confidence: 99%

A population-based prospective birth cohort study of childhood neurocognitive and psychological functioning in healthy survivors of early life meningitis

Khandaker¹,

Štochl²,

Zammit³

et al. 2015

Annals of Epidemiology

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Haemophilus influenzae type b capsular polysaccharide antibody levels in Japanese young patients with hematological malignancies and asplenia

Takeshita

Ishiwada

Takeuchi

et al. 2020

Journal of Infection and Chemotherapy

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Haemophilus influenzae type b meningitis in a vaccinated and immunocompetent child

Almeida

Trindade

Vítor

et al. 2017

Journal of Infection and Public Health

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Invasive Haemophilus influenzae type b (Hib) disease decreased dramatically after the introduction of conjugate vaccine in routine immunization schedules. We report a case of a fifteen-months-old girl, previously healthy and vaccinated, admitted in the emergency room with fever and vomiting. She was irritable and the Brudzinski's sign was positive. The cerebrospinal fluid (CSF) analysis showed pleocytosis and high protein level. Empiric intravenous antibiotics (ceftriaxone and vancomycin) were administered for suspected bacterial meningitis during 10 days. Serotyping of the Haemophilus influenzae strain found in CSF revealed a serotype b. After one year of follow-up no Hib meningitis sequelae were noted. Despite vaccination compliance and absence of risk factors, invasive Hib disease can occur due to vaccine failure. Efforts to keep the low incidence of invasive Hib disease should be directed to the maintenance of high vaccination coverage rates, combined with the notification and surveillance strategies already implemented in each country.

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Long-term complications and risk of other serious infections following invasive Haemophilus influenzae serotype b disease in vaccinated children

Cited by 8 publications

References 26 publications

A population-based prospective birth cohort study of childhood neurocognitive and psychological functioning in healthy survivors of early life meningitis

A population-based prospective birth cohort study of childhood neurocognitive and psychological functioning in healthy survivors of early life meningitis

Haemophilus influenzae type b capsular polysaccharide antibody levels in Japanese young patients with hematological malignancies and asplenia

Haemophilus influenzae type b meningitis in a vaccinated and immunocompetent child

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