Long-term complications of congenital esophageal atresia–single institution experience

Abstract

Objective: To evaluate general health condition of children operated for esophageal atresia, including complications from gastrointestinal tract and skeletal defects. Methods:Between 1990 and 2005, 77 patients were operated for esophageal atresia in the Polish Mother's Health Memorial Hospital. The study was based on retrospective analysis of medical case records of all children with esophageal atresia. All living patients (n=51) were invited for follow-up studies.Results: Pathological gastroesophageal reflux was found in 46.7% of children. Scoliosis was diagnosed in 20 patients. Chest deformations were observed in 43.3% children Conclusion:The absence of clinical symptoms does not exclude the presence of gastroesophageal reflux in children operated for esophageal atresia. Children operated for esophageal atresia should be followed up regularly by a multispecialistic medical team.

Proton pump inhibitors in esophageal atresia: A systematic review and meta‐analysis

“…Nine prospective and seven retrospective studies (representing 2318 patients) addressed the question of the frequency of esophageal histological complications in EA (Figure S1). 20,21,25,27,29,39,49,53–61 When confirmed by MII‐pHm or esophageal biopsies, GERD is present among more than 25% of EA patients of all ages (Figure S2). 16,20–22,24,25,27,29,33,39,42,49,52–57,59–77 Figure S3 represents the pooled prevalence of GERD outcomes with 95% CI according to the different ages.…”

“… 20,21,25,27,29,39,49,53–61 When confirmed by MII‐pHm or esophageal biopsies, GERD is present among more than 25% of EA patients of all ages (Figure S2). 16,20–22,24,25,27,29,33,39,42,49,52–57,59–77 Figure S3 represents the pooled prevalence of GERD outcomes with 95% CI according to the different ages. Histological esophagitis prevalence is high in patients with EA [estimated pooled prevalence 54% (95% CI: 48%–60%)]; however, when considering only moderate and severe cases, this rate drops to 11% (95% CI: 5%–18%).…”

“…20,21,25,27,29,39,49,[53][54][55][56][57][58][59][60][61] When confirmed by MII-pHm or esophageal biopsies, GERD is present among more than 25% of EA patients of all ages (Figure S2). 16,[20][21][22]24,25,27,29,33,39,42,49,[52][53][54][55][56][57][59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75]…”

“…Nine prospective and seven retrospective studies (representing 2318 patients) addressed the question of the frequency of esophageal histological complications in EA (Figure S1). 20,21,25,27,29,39,49,[53][54][55][56][57][58][59][60][61] When confirmed by MII-pHm or esophageal biopsies, GERD is present among more than 25% of EA patients of all ages (Figure S2). 16,[20][21][22]24,25,27,29,33,39,42,49,[52][53][54][55][56][57][59][60][61][62][63][64][65][66][67][68][69][70][71][72]…”