Long-term consequences of prenatal exposure to lead on brain development in rats

Ryzhavskii, B. Ya.; Лебедько, О А; Belolyubskaya, D. S.; Баранова, С. Н.

doi:10.1007/s11055-008-0021-3

Cited by 10 publications

(6 citation statements)

References 6 publications

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“…Dietary patterns identified via PCA were predictive of bone and B-Pb in elderly men in the United States and Sweden, and in Korean adolescents and adults (18–20). To our knowledge, dietary pattern analysis has not been undertaken for pregnant women in association with biomarkers of lead exposure: this is important because the fetus is vulnerable to the effects of lead due to the rapid development of the nervous system (21, 22). During pregnancy, lead crosses the placenta freely (23, 24) and can adversely affect a range of birth outcomes, with the potential for lifelong impact on the growth and development of the child (21).…”

Section: Introductionmentioning

confidence: 99%

Dietary Patterns Are Not Consistently Associated with Variability in Blood Lead Concentrations in Pregnant British Women

Taylor

Doerner

Northstone

et al. 2019

The Journal of Nutrition

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Background During pregnancy lead crosses the placenta freely and can have adverse effects on the fetus, with the potential for lifelong impact on the child. Identification of dietary patterns and food groups in relation to measures of lead status could provide a more useful alternative to nutrient-specific advice to minimize fetal lead exposure. Objectives The aim of this study was to evaluate whether dietary patterns and food groups are associated with blood lead concentration (B-Pb) in pregnancy. Design Whole blood samples were collected at a median of 11 wk gestation (IQR 9–13 wk) from women enrolled in the Avon Longitudinal Study of Parents and Children birth cohort study, and analyzed for lead. Dietary pattern scores were derived from principal components analysis of a food-frequency questionnaire (32 wk gestation). Associations of dietary pattern scores (quartiles), and of food groups (frequency of consumption), with the likelihood of B-Pb ≥5 µg/dL identified with adjusted logistic regression (n = 2167 complete cases). Results There was a negative association between the “confectionery” dietary pattern and the likelihood of B-Pb ≥5 µg/dL (OR: 0.62; 95% CI: 0.41, 0.94) in an adjusted model. There were no associations with other dietary patterns. There was a positive association between the food group “all leafy green and green vegetables” and the likelihood of B-Pb ≥5 µg/dL (OR 1.45; 95% CI: 1.04, 2.01). Conversely, the food group “cakes and biscuits” was negatively associated (OR 0.63; 95% CI: 0.43, 0.93). After multiple imputation, there was a positive association of the “healthy” diet pattern and no association of the “confectionery” pattern. Conclusions We found limited evidence of an association between women's typical diet and B-Pb during pregnancy. Our findings do not indicate need to revise dietary guidance for pregnant women, who are advised to adopt a healthy diet in pregnancy, with a variety of foods consumed in moderation.

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Section: Introductionmentioning

confidence: 99%

Dietary Patterns Are Not Consistently Associated with Variability in Blood Lead Concentrations in Pregnant British Women

Taylor

Doerner

Northstone

et al. 2019

The Journal of Nutrition

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“…Because lead is transferred freely across the placenta (the ratio of fetal:maternal blood lead is about 0.7–0.9 ( Rudge et al, 2009 , Schell et al, 2003 )) and across the blood–brain barrier, in utero exposure to lead may contribute to adverse cognitive outcomes: experimental animal studies suggest that the fetus is particularly vulnerable to the effects of lead because of effects on processes critical to the development of the central nervous system ( Basha and Reddy, 2015 , Ryzhavskii et al, 2008 ). Thus, relatively low levels of exposure that do not greatly harm the mother may have a profound effect on the development of the fetus, and on subsequent development and behaviour during childhood.…”

Section: Introductionmentioning

confidence: 99%

Effects of low-level prenatal lead exposure on child IQ at 4 and 8 years in a UK birth cohort study

et al. 2017

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HighlightsThe association between prenatal exposure to lead and deficits in offspring cognitive function is not well established.Our aim was to evaluate the association between prenatal lead exposure and child IQ at age 4 and 8 years in an observational birth cohort study.There was no association of prenatal lead exposure with child IQ at either 4 or 8 years old.There was a suggestion, however, that boys are more susceptible than girls to prenatal exposure to lead.

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“…Pb exposure during pregnancy is associated with a variety of neonatal perturbations, including low birth weight, delayed development and maturation, as well as later developing behavioural outcomes (Chang et al, 2012 ). Experimental studies demonstrated that administration of Pb to pregnant rats produced destructive changes in the brains of their offspring (Lebed'ko & Ryzhavskii, 2005 ; Ryzhavskii et al, 2008 ). Differential gender effects were also observed after in utero exposure to Pb throughout full gestation (Cory-slechta et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Long-term changes in brain cholinergic system and behavior in rats following gestational exposure to lead: protective effect of calcium supplement

Basha

Reddy

2015

Interdisciplinary Toxicology

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Our earlier studies showed that lactational exposure to lead (Pb) caused irreversible neurochemical alterations in rats. The present study was carried out to examine whether gestational exposure to Pb can cause long-term changes in the brain cholinergic system and behavior of rats. The protective effect of calcium (Ca) supplementation against Pb toxicity was also examined. Pregnant rats were exposed to 0.2% Pb (Pb acetate in drinking water) from gestational day (GD) 6 to GD 21. The results showed decrease in body weight gain (GD 6–21) of dams, whereas no changes were observed in offspring body weight at different postnatal days following Pb exposure. Male offspring treated with Pb showed marginal alterations in developmental landmarks such as unfolding of pinnae, lower and upper incisor eruption, fur development, eye slit formation and eye opening on postnatal day (PND) 1, whereas significant alterations were found in the righting reflex (PNDs 4–7), slant board behavior (PNDs 8–10) and forelimb hang performance (PNDs 12–16). Biochemical analysis showed decrease in synaptosomal acetylcholinesterase (AChE) activity and an increase in acetylcholine (ACh) levels in the cortex, cerebellum and hippocampus on PND 14, PND 21, PND 28 and in the four-month age group of rats following Pb exposure. Significant deficits were also observed in total locomotor activity, exploratory behavior and open field behavior in selected age groups of Pb-exposed rats. These alterations were found to be maximal on PND 28, corresponding with the greater blood lead levels observed on PND 28. Addition of 0.02% Ca to Pb reversed the Pb-induced impairments in the cholinergic system as well as in behavioral parameters of rats. In conclusion, these data suggest that gestational exposure to Pb is able to induce long-term changes in neurological functions of offspring. Maternal Ca administration reversed these neurological effects of Pb later in life, suggesting a protective effect of calcium in Pb-exposed animals.

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Long-term consequences of prenatal exposure to lead on brain development in rats

Cited by 10 publications

References 6 publications

Dietary Patterns Are Not Consistently Associated with Variability in Blood Lead Concentrations in Pregnant British Women

Dietary Patterns Are Not Consistently Associated with Variability in Blood Lead Concentrations in Pregnant British Women

Effects of low-level prenatal lead exposure on child IQ at 4 and 8 years in a UK birth cohort study

Long-term changes in brain cholinergic system and behavior in rats following gestational exposure to lead: protective effect of calcium supplement

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