Long-Term Continuous Production of Soybean Oil-in-Water Emulsions by Microchannel Emulsification

Zhang, Yanru; Kobayashi, Isao; Neves, Marcos A.; Uemura, Kunihiko; Nakajima, Mitsutoshi

doi:10.3136/fstr.19.995

Cited by 5 publications

(1 citation statement)

References 19 publications

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“…There is a separate MC array and terrace along each side of the crossflow channel and thus, the regions in the chip with low droplet productivity. It was more challenging to sustain a long-term generation of uniform droplets in this work than in the previous study [31], due to very low viscosity of DCM compared to that of soybean oil, the presence of dissolved polymers in the dispersed phase that can be deposited on the channel walls and high aqueous solubility of DCM (20 g/L at 20 °C), as compared to almost complete insolubility of soybean oil in water.…”

Section: Introductionmentioning

confidence: 85%

Long-term stability of droplet production by microchannel (step) emulsification in microfluidic silicon chips with large number of terraced microchannels

Vladisavljević

Ekanem

Zhang

et al. 2018

Chemical Engineering Journal

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A long-term production stability of oil-in-water emulsions by microchannel (step) emulsification was investigated using two cross flow silicon chips consisting of 540 or 1,850 microchannels fabricated on 10 parallel terraces. Each terrace was 9.54 mm long and consisted of 54 channels with a depth of 5 m and a width of 18 m (chip 1) or 185 channels with a depth of 4 m and a width of 8 m (chip 2). The dispersed phase was a mixture of 2 wt% polycaprolactone (PCL) and 1 wt% poly(d,l-lactic) acid (PLA) dissolved in dichloromethane and the continuous phase was 2 wt% poly(vinyl alcohol). After solvent evaporation, the droplets were transformed into highly uniform composite polymer particles with an average diameter of 8.8 or 4.9 m. The percentages of active channels, droplet sizes and droplet generation frequencies at individual terraces were investigated in both chips to reveal any flow maldistribution. After 6 h of production in chip 1, overall 95% of the channels produced droplets and the percentage of active channels on each terrace was at least 91%. The percentage of active channels decreased by decreasing the size of the channels. The mean droplet size varied negligibly across individual terraces over 7 h. Slightly higher droplet generation frequencies and smaller percentages of active channels were observed at central terraces. The droplet generation frequencies at the channels located close to each other were similar, indicating that droplet formation dynamics was coupled. The droplet size was not affected by the dispersed phase flow rate.

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Section: Introductionmentioning

confidence: 85%

Long-term stability of droplet production by microchannel (step) emulsification in microfluidic silicon chips with large number of terraced microchannels

Vladisavljević

Ekanem

Zhang

et al. 2018

Chemical Engineering Journal

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Preparation of monodisperse O/W emulsions using a crude surface-active extract from argan by-products in microchannel emulsification

Taarji

Vodo

Bouhoute

et al. 2020

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Microchannel emulsification: A promising technique towards encapsulation of functional compounds

Khalid

Kobayashi

Neves

et al. 2017

Critical Reviews in Food Science and Nutrition

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This review provides an overview of microchannel emulsification (MCE) for production of functional monodispersed emulsion droplets. The main emphasis has been put on functional bioactives encapsulation using grooved-type and straight-through microchannel array plates. MCE successfully encapsulates the bioactives like β-carotene, oleuropein, γ-oryzanol, β-sitosterol, L-ascorbic acid and ascorbic acid derivatives, vitamin D and quercetin. These bioactives were encapsulated in a variety of delivery systems like simple and multiple emulsions, polymeric particles, microgels, solid lipid particles and functional vesicles. The droplet generation process in MCE is based upon spontaneous transformation of interfaces rather than high energy shear stress systems. The scale-up of MCE can increase the productivity of monodispersed droplets >100 L h and makes it a promising tool at industrial level.

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Long-Term Continuous Production of Soybean Oil-in-Water Emulsions by Microchannel Emulsification

Cited by 5 publications

References 19 publications

Long-term stability of droplet production by microchannel (step) emulsification in microfluidic silicon chips with large number of terraced microchannels

Long-term stability of droplet production by microchannel (step) emulsification in microfluidic silicon chips with large number of terraced microchannels

Preparation of monodisperse O/W emulsions using a crude surface-active extract from argan by-products in microchannel emulsification

Microchannel emulsification: A promising technique towards encapsulation of functional compounds

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