Long‐term control of mucocutaneous squamous cell carcinoma and metastases in a horse using piroxicam

Cutaneous squamous cell carcinoma (SCC): “What's the problem?”

“…Daily oral doses of 80 mg of piroxicam (regardless of the size of the horse) have been reported to be helpful (Moore et al . ; Iwabe et al . ).…”

Nonsteroidal Anti‐Inflammatory Drugs and Corticosteroids

“…In cats, piroxicam has been used in the treatment of similar neoplasias. There is a case report on the successful use of piroxicam for the treatment of squamous cell carcinoma in a horse (Moore et al, 2003).…”

Equine periocular neoplasia: Current concepts in aetiopathogenesis and emerging treatment modalities

“…Study design varies widely and may be limited to isolated case reports (Moore et al 2003;Bischofberger et al 2008). Identical treatments administered to similarly-appearing tumour types can have different clinical outcomes.…”

“…Cycloxygenases are a family of enzymes responsible for conversion of arachidonic acid to prostaglandins and multiple isoforms of COX exist, with COX-1 and COX-2 being the most biologically active (Rassnick and Njaa 2007). A limited number of investigations specifically examining the role of COX in naturally occurring equine ocular and periocular SCC have been conducted to date (Elce et al 2007;McInnis et al 2007;Rassnick and Njaa 2007) and interest in this area appears to have arisen largely from a single case report (Moore et al 2003). Correlations have been made in man with head and neck SCC between overexpression of COX-2 in neoplastic tissues and poor prognostic factors (Gallo et al 2002).…”

“…This may be one reason for differences in success rates between studies. from the primary site at the lip to the submandibular lymph nodes) with oral piroxicam (80 mg orally every 24 h) has been reported (Moore et al 2003). Complete regression was observed in 5 of 7 (71%) of the SCC with a 1 year relapse-free rate of 65% (Theon et al 1993).…”