Crude oil transportation in the pipelines of the cold environment is affected by the low temperature causing a problem such as wax deposition. The flow assurance in the hydrocarbon pipelines is very important due to the precipitation of the solid phase of wax on the pipe wall creating pressure abnormalities and causing an artificial blockage leading to a reduction or interruption in the production. Wax can precipitate as a solid phase on the pipe wall when its temperature (inlet coolant temperature) drops below the wax appearance temperature (WAT). In this review, wax deposition process is discussed. Also, proposed wax deposition mechanisms are outlined including molecular diffusion, shear dispersion, Brownian diffusion and gravity settling. Furthermore, the factors affecting the wax deposition process are explained, such as pipe wall temperature (inlet coolant temperature), crude oil composition, crude oil temperature, ambient temperature, flow rate, thermal history, time and pressure. There are several mitigation methods were used in the different oil fields around the world to reduce wax deposition such as pigging, inhibitors and thermal insulation.Citation: Theyab MA. Wax deposition process: mechanisms, affecting factors and mitigation methods. Open Access J Sci. 2018;2(2):109-115.