Long‐Term corticosterone treatment induced lobe‐specific pathology in mouse prostate

Abstract

These data demonstrate that murine prostate is significantly and directly influenced by corticosterone treatment via aberrant stromal-to-epithelial growth factor signaling.

Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism

“…At day 1 after implantation, serum corticosterone levels peaked at 536 ± 85 nmol/l and 489 ± 79 nmol/l in corticosterone-treated WT and Tg mice, respectively, while serum corticosterone levels remained low in placebo-treated WT and Tg animals, at 149 ± 43 and 171 ± 37 nmol/l, respectively. Serum corticosterone was measured by stable isotope dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS) as described previously (56).…”

“…Measurement of serum corticosterone. Serum corticosterone was measured by stable isotope dilution LC-MS/MS as described previously (56).…”

Histomorphometric features of ventral prostate in different aged rats after central ghrelin treatment

“…Obviously, the changes in the ventral prostate size and structure observed in this study cannot be ascribed to alterations in serum testosterone, the hormone which plays major role in the regulation of prostate growth and function. However, other hormones, including GH, are involved in prostate physiology and pathology (Ruan et al 1999;Un-no et al 2007;Simanainen et al 2011). Since ghrelin is a potent physiological stimulator of GH secretion both in vivo and in vitro (Kojima et al 1999;Seoane et al 2000;Stevanovic et al 2006), there is strong evidence that GH and its peripheral mediator of action, insulin-like growth factor I (IGF I) are implicated in the prostate growth and function.…”

The mouse as a model to investigate sex steroid metabolism in the normal and pathological prostate

“…GR is expressed in all lobes of mouse prostate and primarily localised to the stromal and basal epithelial cells [110]. Treatment with glucocorticoids has pharmacological effects on the rodent prostate [110,[116][117][118][119] but the exact mechanism(s) are not understood.…”

“…The principal ligands for the GR are the glucocorticoids such as corticosterone in mice [110] and cortisol in humans [111]. Similarly to PR, the role of GR in the prostate is not well characterised.…”