Long‐term course of restless legs syndrome in dialysis patients after kidney transplantation

Winkelmann, Juliane; Stautner, Anette; Samtleben, W.; Trenkwalder, Claudia

doi:10.1002/mds.10231

Cited by 170 publications

(78 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A minority of RLS cases is secondary to a pre-existing condition (pregnancy, renal failure and iron-deficiency anemia), and resolve with that underlying condition [1,[3][4][5]. Although, many causes of secondary RLS (such as rheumatoid arthritis and diabetes) have been suggested, supporting data are limited and the treatment of these conditions has not been conclusively shown to alleviate RLS.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of restless legs syndrome as diagnosed in UK primary care

2004

View full text Add to dashboard Cite

Background and purpose: Restless legs syndrome (RLS) is a sensorimotor disorder with a general-population prevalence of 5-10%. Although, data on the prevalence of clinically diagnosed RLS are limited, and there are none regarding incidence, a shortfall compared with general-population values is likely, as not all patients are driven to consult. There may also be poor awareness of the condition among primary care physicians (PCPs).Patients and methods: The General Practice Research Database was used to gather prevalence and incidence data from UK PCPs and to investigate PCP awareness over the period 1994-1998. A total of 1,561,692 persons were covered by the database on January 1, 1999.Results: A diagnosis of RLS was registered in 3877 patients, giving a prevalence of 0.25%. Incidence values were also low (41.0 per 100,000 person-years), increased with age and were higher in women than in men. Although, at least one RLS diagnosis was made in 94% of medium-to-large practices, sufferers were more likely than age/sex-matched controls to be diagnosed with conditions commonly confused with RLS in 2 years before receiving their RLS diagnosis. Furthermore, at the time of diagnosis, many sufferers were prescribed medications not effective in RLS (principally, oxerutins and quinine).Conclusion: These data are largely consistent with a lack of awareness of RLS among PCPs in the UK in the period studied. q

show abstract

Section: Introductionmentioning

confidence: 99%

Epidemiology of restless legs syndrome as diagnosed in UK primary care

2004

View full text Add to dashboard Cite

show abstract

“…Similar comparisons have revealed decreased prevalence of RLS in kidney transplant recipients [13]. Moreover, longitudinal studies have described an improvement in RLS symptoms following successful kidney transplantation [14, 15]. These studies have been based on questionnaires regarding RLS and sleep quality without objective polysomnographic monitoring of PLMS.…”

Section: Introductionmentioning

confidence: 99%

Improvement of Periodic Limb Movements following Kidney Transplantation

et al. 2008

View full text Add to dashboard Cite

Background/Aims: Periodic limb movements are common in patients with end-stage renal disease. Kidney transplantation significantly improves renal function and may therefore reduce periodic limb movements. We evaluated the effect of kidney transplantation on periodic limb movements in a group of patients with end-stage renal disease. Methods: Eighteen patients (aged 27–65) who were receiving dialysis and were candidates for living donor or deceased donor kidney transplantation (n = 12) or were predialysis with a suitable living donor arranged (n = 6) were recruited from the transplant clinic. Attended overnight polysomnography was performed before and after kidney transplantation. Patients were divided based on a periodic limb movement index >15 events/h during sleep. Results: Kidney transplantation was associated with a significant reduction in periodic limb movement index in all patients (8 (0–110) events/h vs. 2 (0–80) events/h) and this reduction was greatest in 7 patients with a periodic limb movement index >15 events/h (40 (24–110) events/h to 14 (1–80) events/h, p < 0.005). Conclusion: Successful kidney transplantation improves periodic limb movements in patients with end-stage renal disease. This may improve sleep quality and sleep-related quality of life in kidney transplant recipients, which should have a beneficial impact on clinical outcomes.

show abstract

“…24,25 The better quality of life of transplant patients compared with hemodialyses patients, and the clinical improvement of some dangerous sleeprelated problems (eg, sleep apnea or RLS) may erroneously suggest that sleep problems vanish after a successful transplant. [26][27][28] An association between RLS and insomnia in patients on maintenance dialysis has been suggested already by papers. [29][30][31] In our study, RLS and sleep disturbances were correlated.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Kahvecioğlu

Yıldız²,

Büyükkoyuncu³

et al. 2016

Exp Clin Transplant

View full text Add to dashboard Cite

Objectives: Restless legs syndrome is a disorder in which patients have irresistible urge to move legs during rest. Restless legs syndrome seems to be common in end-stage renal disease. After a successful renal transplant, symptoms ameliorate with renal function improvement and restless legs syndrome is seen less in this population. Here, we aimed to investigate restless legs syndrome frequency and associated factors in renal transplant patients. Materials and Methods:In a cross-sectional study with 193 patients (116 hemodialysis patients, 45 transplant patients, and 32 controls), the presence of restless legs syndrome was assessed using the Restless Legs Syndrome Questionnaire. Medical history, demographic, and laboratory data were collected from the patients' medical records. Patients were questioned about the presence of restless legs syndrome using the Restless Legs Syndrome Questionnaire. Patients were evaluated with Beck Depression Scale for depression and Pittsburgh tests for sleep disturbances. Results: While the rate of restless legs syndrome was similar between transplants and controls, it was significantly greater in hemodialysis patients. Hemodialysis patients and controls had similar depression scores that were higher compared with transplant patients. Pittsburgh score was similar in transplant patients and controls and significantly increased in the hemodialysis patients. The rate of insomnia was significantly higher in the hemodialysis patients compared with the other 2 groups. Logistic regression analysis revealed independent correlates of restless legs syndrome as insomnia, Beck depression score, and being on hemodialysis. Linear regression analysis showed that independent correlates of higher Pittsburgh score were higher depression score, higher age, and presence of restless legs syndrome. Conclusions: The prevalence of restless legs syndrome is significantly lower in transplant patients than it is in patients on maintenance dialysis. In renal transplant patients, restless legs syndrome frequency was found to be lower because of improved renal functions (normalization of uremia), psychological symptoms, and sleep disturbances.

show abstract

Long‐term course of restless legs syndrome in dialysis patients after kidney transplantation

Cited by 170 publications

References 17 publications

Epidemiology of restless legs syndrome as diagnosed in UK primary care

Epidemiology of restless legs syndrome as diagnosed in UK primary care

Improvement of Periodic Limb Movements following Kidney Transplantation

Untitled

Contact Info

Product

Resources

About