Long-term cryostorage of semen in a human sperm bank does not affect clinical outcomes

Huang, Chuan; Lei, Lin; Wu, Hui-Lan; Gan, Run-Xin; Yuan, Xiaobo; Fan, Liqing; Zhu, Wenbing

doi:10.1016/j.fertnstert.2019.06.008

Cited by 36 publications

(16 citation statements)

References 20 publications

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“…As most male cancer survivors express a wish to become biological parents, Joshua A. Halpern, MD, MS, suggested that every patient be treated as if they will lose their fertility potential and be offered sperm cryopreservation as early as possible before cancer treatment is started [ 41 ]. Decades of data have shown that clinical outcomes are not different between fresh and cryopreserved sperm, with a frozen-thaw survival rate of about 75% [ 42 ]. A formal oncofertility program can help overcome persistent barriers to fertility preservation, at the level of the patient, physician, and system.…”

Section: Conference Session Synopsismentioning

confidence: 99%

A synopsis of global frontiers in fertility preservation

Ataman

Laronda

Gowett

et al. 2022

J Assist Reprod Genet

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Since 2007, the Oncofertility Consortium Annual Conference has brought together a diverse network of individuals from a wide range of backgrounds and professional levels to disseminate emerging basic and clinical research findings in fertility preservation. This network also developed enduring educational materials to accelerate the pace and quality of field-wide scientific communication. Between 2007 and 2019, the Oncofertility Consortium Annual Conference was held as an in-person event in Chicago, IL. The conference attracted approximately 250 attendees each year representing 20 countries around the world. In 2020, however, the COVID-19 pandemic disrupted this paradigm and precluded an in-person meeting. Nevertheless, there remained an undeniable demand for the oncofertility community to convene. To maintain the momentum of the field, the Oncofertility Consortium hosted a day-long virtual meeting on March 5, 2021, with the theme of “Oncofertility Around the Globe” to highlight the diversity of clinical care and translational research that is ongoing around the world in this discipline. This virtual meeting was hosted using the vFairs ® conference platform and allowed over 700 people to participate, many of whom were first-time conference attendees. The agenda featured concurrent sessions from presenters in six continents which provided attendees a complete overview of the field and furthered our mission to create a global community of oncofertility practice. This paper provides a synopsis of talks delivered at this event and highlights the new advances and frontiers in the fields of oncofertility and fertility preservation around the globe from clinical practice and patient-centered efforts to translational research. Supplementary Information The online version contains supplementary material available at 10.1007/s10815-022-02570-5.

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Section: Conference Session Synopsismentioning

confidence: 99%

A synopsis of global frontiers in fertility preservation

Ataman

Laronda

Gowett

et al. 2022

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…Although storage time did not influence pregnancy outcomes in our study, in clinical practice, manipulations, such as repeated opening of the cryo-tank, transportation of specimens or laboratory procedures over time, may influence pregnancy outcomes. It was thought that annual cleaning and registering might decrease the frozen-thawed survival rate of sperm specimens with longer storage times (5-15 years) [31]. The composition of the preimplantation human embryo culture media and its stability during storage varied [32].…”

Section: Total Eventsmentioning

confidence: 99%

Storage Time of Cryopreserved Embryos and Pregnancy Outcomes: A Dose-Response Meta-Analysis

Liu

Shi

et al. 2021

Geburtshilfe Frauenheilkd

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Purpose Cryopreservation techniques have become an essential part of assisted reproduction technology. Embryos may be cryopreserved for several years before transfer, and the safety of long-term cryopreservation needs to be considered. This dose-response meta-analysis was conducted to evaluate whether there were dose-response relationships between the storage time of cryopreserved embryos and pregnancy outcomes such as survival rate, implantation rate, miscarriage rate, clinical pregnancy rate, and congenital malformation rate. Methods After searching the databases PubMed, Embase, MEDLINE, CCRT and related reviews up until June 4, 2020, seven studies were included for analysis. Two reviewers extracted the relevant information and independently assessed the study quality using the Newcastle-Ottawa scale. Potential linear or non-linear dose-response relationships were assessed with a random-effect dose-response meta-analysis. Results No dose-response association was found between duration of embryo cryostorage and survival rate, implantation rate, miscarriage rate, clinical pregnancy rate or congenital malformation rate. Conclusion The interval between the start of embryo cryopreservation and frozen/thawed embryo transfer does not influence pregnancy outcomes.

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“…A large meta-analysis of 801 patients showed a 49% live-birth success rate for those men who chose to use cryopreserved sperm (34). Long-term storage of sperm additionally does not adversely affect live-birth rates, with similar rates noted at 5, 10, and 15 years of cryopreservation (35).…”

Section: Adultmentioning

confidence: 99%

Progress in translational reproductive science: testicular tissue transplantation and in vitro spermatogenesis

Pelzman

Orwig

Hwang

2020

Fertility and Sterility

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Since the birth of the first child conceived via in vitro fertilization 40 years ago, fertility treatments and assisted reproductive technology have allowed many couples to reach their reproductive goals. As of yet, no fertility options are available for men who cannot produce functional sperm, but many experimental therapies have demonstrated promising results in animal models. Both autologous (stem cell transplantation, de novo morphogenesis, and testicular tissue grafting) and outside-the-body (xenografting and in vitro spermatogenesis) approaches exist for restoring sperm production in infertile animals with varying degrees of success. Once safety profiles are established and an ideal patient population is chosen, some of these techniques may be ready for human experimentation in the near future, with likely clinical implementation within the next decade. (Fertil Steril Ò 2020;113:500-9. Ó2020 by American Society for Reproductive Medicine.

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Long-term cryostorage of semen in a human sperm bank does not affect clinical outcomes

Cited by 36 publications

References 20 publications

A synopsis of global frontiers in fertility preservation

A synopsis of global frontiers in fertility preservation

Storage Time of Cryopreserved Embryos and Pregnancy Outcomes: A Dose-Response Meta-Analysis

Progress in translational reproductive science: testicular tissue transplantation and in vitro spermatogenesis

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