Long-Term Degradation of a Poly-Lactide Co-Glycolide/β-Tricalcium Phosphate Biocomposite Interference Screw

Revision Rates After Anterior Cruciate Ligament Reconstruction Using Bone–Patellar Tendon–Bone Allograft or Autograft in a Population 25 Years Old and Younger

“…The Milagro biocomposite screw is made from poly L-lactide-co-glycolide and beta-tricalcium phosphate, and this material has demonstrated significant osteoconductivity without any lysis at the screw site. 21,22 In fact, 50% of the screw sites demonstrated significant or complete osseous replacement. 22 The mean follow-up for all included patients was 34 months.…”

“…21,22 In fact, 50% of the screw sites demonstrated significant or complete osseous replacement. 22 The mean follow-up for all included patients was 34 months. The mean allograft follow up was 37 months (range, 24-71 months) and the mean autograft followup was 31 months (range, 24-132 months).…”

Micro- and nano-hydroxyapatite as active reinforcement for soft biocomposites

“…Further studies are therefore needed in order to evaluate the effects of the hydoxyapatite granulometry in biocomposites with a preponderant inorganic phase. For such harder hydrogels, mainly proposed for bone regeneration [18][19][20][21]15,22], the use of n-HA powders could be preferred, in order to mimic the internal architecture of the bone.…”

“…Concerning the inorganic reinforcing phase, tricalciumphospates and hydroxyapatite have been widely employed as reinforcement, due to their bioactive and osteoconductive properties [18][19][20][21]15,22,23]. The size of the inorganic reinforcement has a central role in the determination of the final biocomposite [24].…”

Do Newer-Generation Bioabsorbable Screws Become Incorporated into Bone at Two Years After ACL Reconstruction with Patellar Tendon Graft?

“…The MILAGRO screw, which has been available for clinical use since 2004, consists of 30% b-tricalcium phosphate and 70% poly(lactic-co-glycolic acid) (PLGA). This screw is marketed as bioabsorbable, with ossification occurring at the screw site within several years after surgery 13 .…”