Long-term Development of Significant Visual Field Defects in Highly Myopic Eyes

Ohno‐Matsui, Kyoko; Shimada, Noriaki; Yasuzumi, Kenjiro; Hayashi, Kengo; Yoshida, Takeshi; Kojima, Ariko; Moriyama, Muka; Tokoro, Takashi

doi:10.1016/j.ajo.2011.01.052

Cited by 138 publications

(97 citation statements)

References 19 publications

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“…6 Also, multiple linear regression analyses of a more recent set of data showed that the presence of an abrupt change of the scleral curvature temporal to the optic disc was the only factor associated significantly with a progression of the visual field defects. 8 These results, combined with our present data, suggest that horizontal asymmetry of the posterior surface of the eye might be a cause of optic nerve damage.…”

Section: Discussionsupporting

confidence: 70%

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Quantitative Analyses of High-Resolution 3D MR Images of Highly Myopic Eyes to Determine Their Shapes

Moriyama

Ohno‐Matsui

Modegi

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. We analyzed the symmetry and pointedness of the posterior segment of highly myopic eyes. METHODS.We studied 234 eyes of 117 patients with bilateral high myopia (refractive error À8.00 diopters [D]) and 40 eyes of 20 patients with emmetropia (refractive error between À1.0 and þ1.0 D). Volume renderings of high-resolution magnetic resonance (MR) images were performed to obtain 3D images of the eye. To analyze the symmetry and pointedness of the posterior surface, a software was developed to measure the area and angle of a fan-shaped segment formed by selected points on the MR images.RESULTS. All of the emmetropic eyes were symmetrical in the horizontal and sagittal planes with no deformity. In highly myopic eyes, the shape was symmetrical in the horizontal plane in 146 eyes (62.4%) and in the sagittal plane in 162 (69.2%). The shape of the posterior pole was pointed (angle of fan-shaped segment <1508) in 45.7% and blunted (angle ‡1508) in 54.3% of highly myopic eyes. The most common shape was symmetrical in the horizontal and sagittal planes, and the posterior surface was blunt. The shape of the two eyes of the same individual was the same in 61 of 117 patients (52.1%). In 56 patients whose two eyes had different shapes, the most frequent pattern was a difference in the pointedness (51.8%).CONCLUSIONS. Quantitative assessments of the shape of eyes were useful in determining the pattern of eye shape deformity specific to pathologic myopia. (Invest Ophthalmol Vis Sci.

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Section: Discussionsupporting

confidence: 70%

“…We considered eyes with a loss in >10% of the dots to have significant visual field defects as we have reported previously. 8 …”

Section: Methodsmentioning

confidence: 99%

Quantitative Analyses of High-Resolution 3D MR Images of Highly Myopic Eyes to Determine Their Shapes

Moriyama

Ohno‐Matsui

Modegi

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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“…Approximately 36% of highly myopic eyes with a chronic VF defect had posterior staphyloma, compared with 15% of eyes without a VF defect. 10 Approximately 55% of NTG eyes with myopia had posterior staphyloma in the present study, which is a higher frequency than that previously reported for myopic eyes or highly myopic eyes with a VF defect. 10,22,23 However, because the study population was different and had various means of axial length, direct comparison is difficult.…”

Section: Discussioncontrasting

confidence: 52%

“…A previous study analyzing the development of visual field (VF) defects in highly myopic eyes showed that an abrupt change in scleral curvature due to posterior staphyloma is the only factor significantly associated with VF defect progression, suggesting that stretching and distortion of the optic nerve fibers from scleral changes may contribute to cause optic nerve damage. 10 In the previous study, we demonstrated that the direction of optic disc torsion is related to the location of glaucomatous damage in normal tension glaucoma (NTG) with myopia. 11 We proposed that optic disc torsion and its relationship with the location of the VF defect in myopic NTG eyes may be related to eyeball growth in myopia.…”

Section: Introductionmentioning

confidence: 99%

Posterior staphyloma is related to optic disc morphology and the location of visual field defect in normal tension glaucoma patients with myopia

Park

Jung

Park

2014

Eye

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Purpose To determine the morphologic features of the optic disc and the location of visual field (VF) defect in relation to posterior staphyloma in normal tension glaucoma (NTG) eyes with myopia. Methods One hundred and thirty-four NTG patients with myopia were enrolled. B-scan ultrasonography was performed in enrolled patients. Disc tilt ratio, disc torsion, and area of peripapillary atrophy were measured from disc photographs. Patients were classified according to the presence of posterior staphyloma and its location: staphyloma involving the optic disc, staphyloma involving either the supero-temporal side of the optic disc or the infero-temporal side of the optic disc. The relationship between the location of the posterior staphyloma and that of the VF defect was analyzed. Results Among 134 eyes, 74 eyes (55.2%) had posterior staphyloma on B-scan ultrasonography. Mean torsion degree was significantly greater in eyes with staphyloma involving the temporal side of the optic disc (19.78±18.001) compared with eyes with staphyloma involving the optic disc (4.65±4.921, P ¼ 0.001). The frequency of the location of VF damage differed significantly between eyes with staphyloma involving the supero-temporal side and those involving the infero-temporal side of the optic disc (P ¼ 0.008), which was not significant in eyes with staphyloma involving the optic disc (P ¼ 0.813).Conclusions Optic disc torsion was a prominent finding in myopic NTG eyes when posterior staphyloma was located temporal to the optic disc. The location of posterior staphyloma was related to the direction of disc torsion and the location of VF defect.

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“…Furthermore, thinning of the lamina cribrosa decreases the distance between the intraocular and retrobulbar cerebrospinal fluid compartment spaces, causing steeper pressure gradients [23]. The combination of stretching and distortion of the optic nerve fibers resulting from an abrupt change in the scleral curvature may lead to optic nerve fiber damage in highly myopic eyes [24]. These factors might contribute to the lamina cribrosa having a higher vulnerability to glaucomatous damage in a myopic disc than in a nonmyopic disc [25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Comparison of myopic and nonmyopic disc hemorrhage in primary open-angle glaucoma

et al. 2012

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Long-term Development of Significant Visual Field Defects in Highly Myopic Eyes

Cited by 138 publications

References 19 publications

Quantitative Analyses of High-Resolution 3D MR Images of Highly Myopic Eyes to Determine Their Shapes

Quantitative Analyses of High-Resolution 3D MR Images of Highly Myopic Eyes to Determine Their Shapes

Posterior staphyloma is related to optic disc morphology and the location of visual field defect in normal tension glaucoma patients with myopia

Comparison of myopic and nonmyopic disc hemorrhage in primary open-angle glaucoma

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