Long-Term Dietary Supplementation of Pomegranates, Figs and Dates Alleviate Neuroinflammation in a Transgenic Mouse Model of Alzheimer’s Disease

Essa, Musthafa Mohamed; Subash, Selvaraju; Akbar, Mohammed; Al-Adawi, Samir; Guillemin, Gilles J.

doi:10.1371/journal.pone.0120964

Cited by 94 publications

(76 citation statements)

References 95 publications

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“…Another study was made to examine the beneficial effects of dietary supplements containing pomegranate, figs, or the dates on suppressing inflammatory cytokines. Finding confirmed that increased levels of inflammatory cytokines and eotaxin activity were decreased by administration of the diet supplements [54].…”

Section: Nematicidal Activitysupporting

confidence: 52%

Ficus Carica and Its Constituents Role in Management of Diseases

Rahmani

Aldebasi

2017

Asian J Pharm Clin Res

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Alternative medicines or formulation based on natural sources are good option in diseases cure and prevention. Ficus carica is member of Moraceae family and its health management properties have been mentioned in religious books and traditional medicines. It holds various constituents including phenolic compounds, minerals and vitamins and such ingredient shows role in disease cure. Studies based on in vivo and in vitro reported that figs fruits, stem, leaves, and latex have health management effect through antioxidant, anti-inflammatory effects, antimicrobial, anticarcinogenic, and anti-inflammatory effects. Moreover, an inverse correlation between figs use and development of disease has been noticed. Despite its implications in disease management, little is known about their mechanism of action. In this review, efforts are made based on in vivo and in vitro studies to illuminate the role of F. carica leaves and fruits in the prevention of diseases.

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Section: Nematicidal Activitysupporting

confidence: 52%

Ficus Carica and Its Constituents Role in Management of Diseases

Rahmani

Aldebasi

2017

Asian J Pharm Clin Res

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“…Both berry-containing diets improved the spatial working memory deficit of aged APdE9 AD mice compared to the corresponding mice fed the control diet, suggesting that anthocyanin-rich bilberry and blackcurrant supplements favorably modulate APP processing and improve behavioral abnormalities in the AD mouse model (Tapias et al, 2014). Long-term oral administration of pomegranate extracts significantly prevented the elevated production of pro-inflammatory cytokines in the serum and brain tissues as well as neuronal contents of Aβ1–40 and Aβ1–42 in a transgenic mouse model of AD (Essa et al, 2015). …”

Section: Translational Research Opportunities and Challengesmentioning

confidence: 99%

Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress

et al. 2016

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Mitochondria are important for providing cellular energy ATP through the oxidative phosphorylation pathway. They are also critical in regulating many cellular functions including the fatty acid oxidation, the metabolism of glutamate and urea, the anti-oxidant defense, and the apoptosis pathway. Mitochondria are an important source of reactive oxygen species leaked from the electron transport chain while they are susceptible to oxidative damage, leading to mitochondrial dysfunction and tissue injury. In fact, impaired mitochondrial function is commonly observed in many types of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, alcoholic dementia, brain ischemia-reperfusion related injury, and others, although many of these neurological disorders have unique etiological factors. Mitochondrial dysfunction under many pathological conditions is likely to be promoted by increased nitroxidative stress, which can stimulate post-translational modifications (PTMs) of mitochondrial proteins and/or oxidative damage to mitochondrial DNA and lipids. Furthermore, recent studies have demonstrated that various antioxidants, including naturally occurring flavonoids and polyphenols as well as synthetic compounds, can block the formation of reactive oxygen and/or nitrogen species, and thus ultimately prevent the PTMs of many proteins with improved disease conditions. Therefore, the present review is aimed to describe the recent research developments in the molecular mechanisms for mitochondrial dysfunction and tissue injury in neurodegenerative diseases and discuss translational research opportunities.

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“…The current interest in the benefits to human health of antioxidant compounds of fruits has led to many research projects in the field of AD [1]. …”

Section: Introductionmentioning

confidence: 99%

“…The anti-inflammatory effects of pomegranate pulp extract were also observed in mouse models of AD, including a decrease in IL-6 and TNF-α in mouse brain samples [1,6]. This effect could contribute to attenuation of progression of the disease, once a prominent chronic inflammatory reaction is observed with the development of neurodegeneration.…”

Section: Introductionmentioning

confidence: 99%

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Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-β Peptide in Mice

et al. 2016

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Alzheimer’s disease is a chronic and degenerative condition that had no treatment until recently. The current therapeutic strategies reduce progression of the disease but are expensive and commonly cause side effects that are uncomfortable for treated patients. Functional foods to prevent and/or treat many conditions, including neurodegenerative diseases, represent a promising field of study currently gaining attention. To this end, here we demonstrate the effects of pomegranate (Punica granatum) peel extract (PPE) regarding spatial memory, biomarkers of neuroplasticity, oxidative stress and inflammation in a mouse model of neurodegeneration. Male C57Bl/6 mice were chronically infused for 35 days with amyloid-β peptide 1–42 (Aβ) or vehicle (control) using mini-osmotic pumps. Another group, also infused with Aβ, was treated with PPE (p.o.– βA+PPE, 800 mg/kg/day). Spatial memory was evaluated in the Barnes maze. Animals treated with PPE and in the control group exhibited a reduction in failure to find the escape box, a finding that was not observed in the Aβ group. The consumption of PPE reduced amyloid plaque density, increased the expression of neurotrophin BDNF and reduced the activity of acetylcholinesterase enzyme. A reduction in lipid peroxidation and in the concentration of the pro-inflammatory cytokine TNF-α was also observed in the PPE group. No hepatic lesions were observed in animals treated with PPE. In conclusion, administration of pomegranate peel extract has neuroprotective effects involving multiple mechanisms to prevent establishment and progression of the neurodegenerative process induced by infusion with amyloid-β peptide in mice.

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Long-Term Dietary Supplementation of Pomegranates, Figs and Dates Alleviate Neuroinflammation in a Transgenic Mouse Model of Alzheimer’s Disease

Cited by 94 publications

References 95 publications

Ficus Carica and Its Constituents Role in Management of Diseases

Ficus Carica and Its Constituents Role in Management of Diseases

Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress

Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-β Peptide in Mice

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