Long‐term disease‐free survival of patients with radically resected thymomas

Abstract

BACKGROUNDDespite radical surgical resection, thymomas often recur. The objective of the current retrospective study was to investigate the prognostic relevance of the expression of cell‐cycle proteins in these neoplasms to formulate a possible therapeutic surveillance strategy for the prevention of recurrence.METHODSThe authors retrospectively reviewed the main clinicopathologic factors, including the World Health Organization (WHO) classification, of patients with thymoma who had undergone radical surgical resection. Specimens were studied using immunohistochemistry and the expression of cell‐cycle proteins (i.e., p21, p27, and p53) was assessed. Univariate and multivariate analysis of predicting survival prognostic factors were performed.RESULTSThe authors analyzed 88 patients with thymoma who underwent radical surgical resection at the study institution. According to the Masaoka staging system, 41 patients had Stage I disease, 31 patients had Stage II disease, and 16 patients had Stage III disease. There were 24 tumor recurrences (27.3%), 4 of which were local, 16 of which were distant intrathoracic, and 4 of which were extrathoracic. The second radical resection provided a disease‐free survival rate that was similar to the first. Only Masaoka stage (P = 0.001), WHO classification (P=0.001), high expression of p53 (P=0.03), and low expression of p21 (P=0.02) and p27 (P=0.001) were found to be correlated with a reduced disease‐free survival. Low p27 expression was found to be the most significant predictive factor of a short disease‐free survival (P=0.001), especially when associated with low p21 expression and high p53 expression (P=0.0001).CONCLUSIONSLong‐term disease‐free survival in thymoma patients treated with radical surgical resection was found to be correlated with Masaoka stage, WHO classification, and expression of cell‐cycle proteins, with the latter found to be the most significant predictive factor. Functional cooperation between cell‐cycle proteins might constitute another level of regulation in tumor growth. More careful surveillance should be adopted whenever there is negative cell‐cycle protein expression. Cancer 2005. © 2005 American Cancer Society.

A Phase I/II Trial of Belinostat in Combination with Cisplatin, Doxorubicin, and Cyclophosphamide in Thymic Epithelial Tumors: A Clinical and Translational Study

“…40 The prognostic role of p21 expression in radically-resected thymoma has been described by Mineo et al who found an association between low tumoral expression of p21 and reduced disease-free survival. 41 Although our data indicate a possible predictive role of p21 expression, given the small sample sizes, the significance of this finding will have to be further evaluated in larger samples. Detection and visualization of γ-H2AX, the phosphorylated form of the H2AX protein, provides a useful assessment of DNA damage.…”

Micronodular thymic tumor with lymphoid stroma: A case report and review of the literature

“…Compared with thymoma, it has more expression in thymic carcinoma, and it also has higher expression levels in invasive thymoma than in noninvasive thymoma. Other studies have shown that P53 is also associated with shorter disease-free survival and overall survival[16]. Overexpression of HER2 is rare in thymoma but relatively common in thymic carcinoma[15].…”

Prognostic Factors and Radiotherapy in Thymic Epithelial Tumors: A single institutional experience

“…MG varlığı, ileri yaş, tümör çapı (≥8 cm), hücre siklus protein ekspresyonu gibi birçok faktör ek prognostik faktör (PF) olarak tanım-lanmıştır (27)(28)(29) .…”