Long-term drug delivery using implantable electrospun woven polymeric nanotextiles

Enhancing Delivery of Small‐Molecule‐ and Cell‐Based Therapies for Ovarian Cancer Using Advanced Delivery Strategies

“…[ 148 ] Electrospun polydioxanone nanoyarns have also been loaded with paclitaxel to achieve sustained paclitaxel release. [ 149 ] Varying the packing density of the nanoyarns allowed modulation of the paclitaxel release rate which might allow patient specific dosing to be achieved. In vivo sustained release of paclitaxel was achieved for 60 days in mice.…”

“…In vivo sustained release of paclitaxel was achieved for 60 days in mice. [ 149 ] In a mouse model of ovarian cancer using ID8–VEGF cancer cells, the paclitaxel nanoyarns (20 mg kg −1 paclitaxel) achieved complete removal of the tumors compared to IP paclitaxel (20 mg kg −1 ) on day 35 post‐tumor cell injection (day 27 post‐treatment start). [ 150 ] Such a system might reduce the frequency of dosing required and improve patient quality of life.…”

A review of smart electrospun fibers toward textiles

“…In one application of drug release, paclitaxel (PTX), a drug loaded in the twisted warp and weft yarns during the formation of electrospun fibers, was used to study the effect of packing density of plain-woven fabrics on the drug release profile. The long-term drug release profile was achieved by the diffusion effect combined with the matrix degradation [ 59 ].…”

In vitro characterization of a synthetic polyamide-based erodible compact disc for extended drug release

“…Polymer-based extended release drug carriers have received increased attention in recent times and this is predominantly because of their numerous clinical and biomedical advantages, which include reduced dosing frequency, administration site-specificity, minimized adverse effects, effective management of chronic conditions, improved bioavailability, fewer medical visits and better patient compliance [2,[10][11][12][13]. They are widely applied as invasive or non-invasive platforms typified by their unique functionalities which are based on novel delivery technologies such as reservoir systems, monolithic matrices, pumps (osmotic, peristaltic, infusion) and nano/micro structures [13].…”