Long-term effect of comorbidity on the course of physical functioning in patients after stroke and with multiple sclerosis

Dallmeijer, AJ; Beckerman, Heleen; Groot, Vincent de; Port, IG van de; Lankhorst, GJ; Dekker, J.

doi:10.2340/16501977-0335

Cited by 38 publications

(23 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…102 In a 3-year observational study of 146 patients with recently diagnosed MS, those with musculoskeletal comorbidities experienced a 5-point decline in the motor scale of the Functional Independence Measure, whereas those without such comorbidities experienced only a 2-point decline. 103 Marrie and colleagues 104 evaluated the association between vascular comorbidities, including hypertension, hyperlipidemia, heart disease, diabetes, and peripheral vascular disease, and disability progression among 8983 participants in the NARCOMS Registry. When compared with participants who did not report vascular comorbidities at diagnosis, those with vascular comorbidities had an increased risk of early gait disability (HR 1.70; 95% CI: 1.54-1.87), need for a unilateral assistive device to walk (HR 1.68; 95% CI: 1.51-1.87), and need for a bilateral assistive device to walk (HR 1.48; 95% CI: 1.26-1.74).…”

Section: Comorbiditymentioning

confidence: 99%

Demographic, Genetic, and Environmental Factors That Modify Disease Course

Marrie

2011

Neurologic Clinics

View full text Add to dashboard Cite

Section: Comorbiditymentioning

confidence: 99%

Demographic, Genetic, and Environmental Factors That Modify Disease Course

Marrie

2011

Neurologic Clinics

View full text Add to dashboard Cite

“…Research on how MS-patients are affected by co-morbidities has so far focused on other outcomes than disability pension (DP), such as ambulatory disability, [7] health-related quality of life, [8] and physical functioning [9]. It has been reported that MS patients with vascular disorders are more likely to suffer from ambulatory disability, [7] that MS patients with musculoskeletal disorders have a more rapid decline of motor functions, [10] and that mental disorders among MS patients are linked to decreased physical functioning [11] and increased perceived disability [12].…”

Section: Introductionmentioning

confidence: 99%

Co-morbidities increase the risk of disability pension among MS patients: a population-based nationwide cohort study

et al. 2014

View full text Add to dashboard Cite

BackgroundMultiple sclerosis (MS) is a chronic and often disabling disease. In 2005, 62% of the MS patients in Sweden aged 16–65 years were on disability pension. The objective of this study is to investigate whether the presence of common co-morbidities increase MS patients’ risk for disability pension.MethodsThis population-based cohort study included 4 519 MS patients and 4 972 174 non-MS patients who in 2005 were aged 17–64 years, lived in Sweden, and were not on disability pension. Patients with MS were identified in the nationwide in- and outpatient registers, while four different registers were used to construct three sets of measures of musculoskeletal, mental, and cardiovascular disorders. Time-dependent proportional hazard models with a five-year follow up were performed, adjusting for socio-demographic factors.ResultsAll studied disorders were elevated among MS patients, regardless of type of measure used. MS patients with mental disorders had a higher risk for disability pension than MS patients with no such co-morbidities. Moreover, mental disorders had a synergistic influence on MS patients’ risk for disability pension. These findings were also confirmed when conducting sensitivity analyses. Musculoskeletal disorders appeared to increase MS patients’ risk for disability pension. The results with regard to musculoskeletal disorders’ synergistic influence on disability pension were however inconclusive. Cardiovascular co-morbidity had no significant influence on MS-patients’ risk for disability pension.ConclusionsCo-morbidities, especially mental disorders, significantly contribute to MS patients’ risk of disability pension, a finding of relevance for MS management and treatment.

show abstract

“…21 Finally, a prospective study of Dallmeijer and co-workers found that only 5% of pMS were affected by CVD. 22 In summary, the literature is limited and the existing data inconsistent. However, the best designed studies, characterised by a higher level of evidence, suggest a slightly increased risk of dying from CVD and a higher prevalence of CVD in pMS.…”

Section: Databasementioning

confidence: 99%

Risk factors related to cardiovascular diseases and the metabolic syndrome in multiple sclerosis – a systematic review

et al. 2013

View full text Add to dashboard Cite

Despite many epidemiological studies examining comorbidity in people with multiple sclerosis (pMS), there are conflicting opinions on whether pMS are at more or less risk of cardiovascular disease (CVD) and the metabolic syndrome compared with the general population. As pMS can now expect longer survival, this as an important question both at an individual and public health level. This study aimed to systematically review the literature linking MS to CVD risks and to the risk factors constituting the metabolic syndrome. This systematic review is based on a comprehensive literature search of six databases (Swemed+, Pubmed, Embase, Cochrane, PEDro and CINAHL). In total 34 studies were identified. Despite the high number of identified papers, only limited and inconsistent data exist on the risk factors of the metabolic syndrome and MS. Overall, the data suggest an increased CVD risk in pMS. From the existing studies it is not clear whether the increased risk of CVD is related to an increased risk of obesity or changes in body composition, hypertension, dyslipidemia or type II diabetes in pMS, indicating the need for future research in the field, if we are to advise pMS adequately in avoiding preventable comorbidity.

show abstract

Long-term effect of comorbidity on the course of physical functioning in patients after stroke and with multiple sclerosis

Cited by 38 publications

References 18 publications

Demographic, Genetic, and Environmental Factors That Modify Disease Course

Demographic, Genetic, and Environmental Factors That Modify Disease Course

Co-morbidities increase the risk of disability pension among MS patients: a population-based nationwide cohort study

Risk factors related to cardiovascular diseases and the metabolic syndrome in multiple sclerosis – a systematic review

Contact Info

Product

Resources

About