Long-Term Effect of COVID-19 on Lung Imaging and Function, Cardiorespiratory Symptoms, Fatigue, Exercise Capacity, and Functional Capacity in Children and Adolescents: A Systematic Review and Meta-Analysis

Campos, Catherine; Prokopich, Samantha; Loewen, Hal; Sanchez-Ramirez, Diana C.

doi:10.3390/healthcare10122492

Cited by 15 publications

(10 citation statements)

References 49 publications

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“…Our data shows that one-third of LCC participants have not returned to their regular activities and 8% required help to complete their ADLs ≥3 months after infection. It has been observed that LCC affects patients’ physical function, ability to return to work, school or other regular activities, and impacts their health-related quality of life ( 8 , 38 ). However, to the best of our knowledge, this is the first study to identify that activity limitations were more likely to be reported by men and older participants.…”

Section: Discussionmentioning

confidence: 99%

Exploring long COVID condition in Latin America: Its impact on patients’ activities and associated healthcare use

et al. 2023

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BackgroundStudies exploring long COVID condition (LCC) in low- and middle-income countries are scarce. Further characterization of LCC patients experiencing activity limitations and their associated healthcare use is needed. This study aimed to describe LCC patients’ characteristics, its impact on activities, and associated healthcare use in Latin America (LATAM).ParticipantsIndividuals who (cared for someone or) had COVID-19 and could read, write, and comprehend Spanish and lived in a LATAM country were invited to complete a virtual survey. Sociodemographic characteristics, COVID-19 and LCC symptoms, activity limitations, and healthcare use.ResultsData from 2,466 people from 16 countries in LATAM were analyzed (females = 65.9%; mean age of 39.5 ± 53.3 years). 1,178 (48%) of the respondents had LCC symptoms (≥3 months). These were more likely to have COVID-19 earlier in the pandemic, were older, had no COVID vaccines, had more comorbidities, needed supplementary oxygen, and reported significantly more COVID-19 symptoms during the infectious period. 33% of the respondents visited a primary care provider, 13% went to the emergency department, 5% were hospitalized, 21% visited a specialist, and 32% consulted ≥1 therapist for LCC symptoms mainly extreme fatigue, sleep difficulties, headaches, muscle or joint pain, and shortness of breath with activity. The most consulted therapists were respiratory therapists (15%) and psychologists (14%), followed by physical therapists (13%), occupational therapists (3%), and speech pathologists (1%). One-third of LCC respondents decreased their regular activities (e.g., work, school) and 8% needed help with activities of daily living (ADLs). LCC respondents who reduced their activities reported more difficulty sleeping, chest pain with activity, depression, and problems with concentration, thinking, and memory, while those who needed help with ADLs were more likely to have difficulty walking, and shortness of breath at rest. Approximately 60% of respondents who experienced activity limitations sought a specialist and 50% consulted therapists.Conclusions and relevanceResults supported previous findings in terms of the LCC demographics, and provided insight into LCC impact on patients’ activities and healthcare services used in LATAM. This information is valuable to inform service planning and resource allocation in alignment with the needs of this population.

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Section: Discussionmentioning

confidence: 99%

Exploring long COVID condition in Latin America: Its impact on patients’ activities and associated healthcare use

et al. 2023

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“…Additional file 9 [ 40 , 69 , 75 , 97 , 108 , 109 , 117 , 122 , 123 , 132 , 137 ] summarizes single-arm evidence about COVID-19-associated MIS-C. Additional file 10 [ 62 , 156 , 157 ] summarizes single-arm evidence about newborns from COVID-19-diagnosed mothers. Additional file 11 [ 47 , 87 ] summarizes single-arm evidence about long-COVID. Additional file 12 [ 54 , 67 , 77 , 139 , 153 ] summarizes single-arm evidence about events caused by the COVID-19 vaccine.…”

Section: Resultsmentioning

confidence: 99%

Evidence linking COVID-19 and the health/well-being of children and adolescents: an umbrella review

Duan,

Liu,

Wang

et al. 2024

BMC Med

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Background Experiences during childhood and adolescence have enduring impacts on physical and mental well-being, overall quality of life, and socioeconomic status throughout one’s lifetime. This underscores the importance of prioritizing the health of children and adolescents to establish an impactful healthcare system that benefits both individuals and society. It is crucial for healthcare providers and policymakers to examine the relationship between COVID-19 and the health of children and adolescents, as this understanding will guide the creation of interventions and policies for the long-term management of the virus. Methods In this umbrella review (PROSPERO ID: CRD42023401106), systematic reviews were identified from the Cochrane Database of Systematic Reviews; EMBASE (OvidSP); and MEDLINE (OvidSP) from December 2019 to February 2023. Pairwise and single-arm meta-analyses were extracted from the included systematic reviews. The methodological quality appraisal was completed using the AMSTAR-2 tool. Single-arm meta-analyses were re-presented under six domains associated with COVID-19 condition. Pairwise meta-analyses were classified into five domains according to the evidence classification criteria. Rosenberg’s FSN was calculated for both binary and continuous measures. Results We identified 1551 single-arm and 301 pairwise meta-analyses from 124 systematic reviews that met our predefined criteria for inclusion. The focus of the meta-analytical evidence was predominantly on the physical outcomes of COVID-19, encompassing both single-arm and pairwise study designs. However, the quality of evidence and methodological rigor were suboptimal. Based on the evidence gathered from single-arm meta-analyses, we constructed an illustrative representation of the disease severity, clinical manifestations, laboratory and radiological findings, treatments, and outcomes from 2020 to 2022. Additionally, we discovered 17 instances of strong or highly suggestive pairwise meta-analytical evidence concerning long-COVID, pediatric comorbidity, COVID-19 vaccines, mental health, and depression. Conclusions The findings of our study advocate for the implementation of surveillance systems to track health consequences associated with COVID-19 and the establishment of multidisciplinary collaborative rehabilitation programs for affected younger populations. In future research endeavors, it is important to prioritize the investigation of non-physical outcomes to bridge the gap between research findings and clinical application in this field.

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“…Moreover, attributed to respiratory restriction and other reasons, exercise tolerance decreased by different proportions in different patient groups. Their quality of life and psychological assessment results also demonstrated they were influenced at different degrees ( 35 , 39 ). In a number of case reports about pulmonary function, the assessment of children cases after recovering from COVID-19 did not show a significant impact, different from the generally impaired pulmonary function of adults.…”

Section: Clinical Manifestation Of Long Covid In Different Systemmentioning

confidence: 98%

Advances in researches on long coronavirus disease in children: a narrative review

Zhang,

Kuang,

Liu

2024

Transl Pediatr

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Background and Objective In the context of the global pandemic of coronavirus disease 2019 (COVID-19), more than 700 million infections and millions of deaths have occurred in countries around the world. Currently, two main sequelae of this disease are considered to occur in children, namely, multi-system inflammatory syndrome in children and long COVID. Among these two, the incidence of long COVID is higher and its impact on the population is more extensive, which is the focus of us. However, due to the lack of relevant studies and the limitations of most studies, the studies on sequelae of COVID-19 infection lag behind those of adults, but they have begun to attract the attention of some clinicians and researchers. We aim to summarize the current knowledge of long COVID in children, helping pediatricians and researchers to better understand this disease and providing guidance on research and clinical treatment of it. Methods We reviewed all the studies on “long COVID”, pediatric, children, adolescent, post-COVID syndrome in PubMed published after 2019. Key Content and Findings This review summarizes the latest researches on epidemiology, pathogenesis, clinical manifestations, prevention and treatment of long COVID in children. Based on the existing research data, we summarized and analyzed the characteristics of long COVID in children, discovering the means to decipher the diagnosis of COVID-19 in children and some potential therapeutic treatments. Conclusions We aim to summarize existing research on long COVID in children and help pediatricians and government agencies quickly understand the disease so that it can be used for clinical diagnosis, treatment and prevention in the population. In addition, providing a research basis for further researches on the cellular and even molecular level to explain the occurrence and development of diseases, and has a guiding role for future research direction.

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Long-Term Effect of COVID-19 on Lung Imaging and Function, Cardiorespiratory Symptoms, Fatigue, Exercise Capacity, and Functional Capacity in Children and Adolescents: A Systematic Review and Meta-Analysis

Cited by 15 publications

References 49 publications

Exploring long COVID condition in Latin America: Its impact on patients’ activities and associated healthcare use

Exploring long COVID condition in Latin America: Its impact on patients’ activities and associated healthcare use

Evidence linking COVID-19 and the health/well-being of children and adolescents: an umbrella review

Advances in researches on long coronavirus disease in children: a narrative review

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