Long-term effect of ovariectomy on dopamine-stimulated adenylate cyclase in rat striatum and nucleus accumbens

Kumakura, Konosuke; Hoffman, Madeleine; Trabucchi, Marco; Spano, PierFranco; Müller, Eugenio E.

doi:10.1007/bf00426803

Cited by 29 publications

(11 citation statements)

References 14 publications

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“…In guinea pigs, ovariectomy decreased the intensity of amphetamine or apomorphine-elicited ste reotyped behavior [17]. This decreased behavioral activity may also be related to a reported decrease in striatal dop amine-stimulated adenylate cyclase activity folowing long term ovariectomy [14], Intriguingly, there is only a slight decrease in striatal dopamine-stimulated adenylate cyclase activity with hypophysectomy [14]. This suggests that the gonadal steroid modulation of striatal dopamine activity may be mediated by pituitary hormones.…”

Section: Discussionmentioning

confidence: 80%

Experimental Studies on the Development of Sex Differences in the Release of Dopamine from Striatal Tissue Fragments in vitro

Becker

Ramírez²

1981

Neuroendocrinology

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Sex differences have been reported in the amphetamine-stimulated release of dopamine from rat striatal tissue fragments in vitro. The present experiments were conducted to further investigate these sex differences. Employing an in vitro perifusion system, we examined the amphetamine-stimulated release of dopamine from striatal tissue of male and female rats: (1) at 4, 19, and 31 days of age; (2) as adults, after receiving hormone treatments neonatally that are known to alter the pattern of gonadotropin release, and (3) as adults, following postpubertal ovariectomy (OVX) or castration (CAST). There were no sex differences in dopamine release at 4, 19 or 31 days of age. Amphetamine elicited significant dopamine release from striatal tissue at all of these ages, regardless of the sex of the donor. There was significant amphetamine-stimulated dopamine release from striatal tissue obtained from both feminized males (CAST at day 2, tested as adults) and control males (CAST at day 15, tested as adults). Striatal tissue obtained from both androgenized females (500 µg testosterone propionate on day 2, OVX day 15, tested as adults) and control females (OVX day 15, tested as adults) also showed significant amphetamine-stimulated dopamine release. These later results are in marked contrast to the results obtained when female rats were ovariectomized postpubertally. Striatal tissue obtained from female rats, OVX as adults, fails to show significant dopamine release when stimulated with amphetamine. In adult OVX females, this attenuation of amphetamine-stimulated dopamine release is seen as early as 11 days after OVX and persists for at least 45 days. However, the effect of CAST in adult males does not differ from its effects in immature males. Striatal tissue obtained from adult males 45 days after CAST, shows significant amphetamine-stimulated release of dopamine. The experiments reported here confirm our previous results of a sex difference in the responsiveness of striatal tissue to amphetamine stimulation. We conclude that this sex difference in amphetamine-stimulated dopamine release from the striatum is not a function of the organizational effects of neonatal androgen exposure, but develops later in life, perhaps in association with puberty.

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Section: Discussionmentioning

confidence: 80%

Experimental Studies on the Development of Sex Differences in the Release of Dopamine from Striatal Tissue Fragments in vitro

Becker

Ramírez²

1981

Neuroendocrinology

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“…For example, injection of large doses of estrogen has been re ported to increase the duration of stereotypy induced by DA agonists (165). Additionally, stereotypy duration was reduced in guinea pigs after ovariec tomy (166), as was the in vitro response of adenylate cyclase to DA in homogenates prepared from the striata of ovariectomized rats (167). Al though estrogen has mUltiple effects on DA metabolism and can increase the penetration of dopaminergic drugs into the eNS (168), estrogen does appear to modulate DA receptor sensitivity (169,170).…”

Section: Miscellaneous Drugsmentioning

confidence: 98%

Receptor Adaptations to Centrally Acting Drugs

Creese¹,

Sibley²

1981

Annu. Rev. Pharmacol. Toxicol.

290

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“…Ovariectomy (OVX) leads over 4-6 weeks to a decrease of dopamine and apomorphine stimulated adenylate cyclase in rat striatum and nucleus accumbens; at shorter times after OVX, DA sensitivity of adenylate cyclase may be en hanced (120). OVX also leads to a reduction in the ability of amphetamine to stimulate DA and noradrenaline release from rat striatal tissue (121), as well as a decrease in amphetamine stimulation of activity in a shuttle box (122).…”

Section: Striatummentioning

confidence: 98%

“…Hypophysectomy, unlike ovariectomy, does not change DA-stimulated adenylate cyclase activity in striatum and accumbens (120). Moreover, hypophysectomy tends to reduce or abolish certain estrogen effects, leading to the presumption that they normally may be mediated by elevated prolac tin pituitary hormone (e.g.…”

Section: Striatummentioning

confidence: 98%

Gonadal Steroid Action on the Brain: Neurochemistry and Neuropharmacology

McEwen¹,

Parsons²

1982

Annu. Rev. Pharmacol. Toxicol.

189

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INTRODUCTIONSteroid hormones of the gonads and adrenals influence the brain and alter the affective state as well as· overt behavior and neuroendocrine function. These actions are manifested in various ways and at various levels of obser vation and experimentation. For example, in female vertebrates of many species, estrogens prime the brain and pituitary gland and make possible the occurrence of ovulation and sexual receptivity. Androgens, On the other hand, facilitate male reproductive behavior including vocalizations (e.g. song in passerine birds, mate-calling in frogs), defense of territory and related aggressive displays, and copulatory behavior. At another level of analysis, estrogen treatment counteracts tardive diskinesia and L-DOPA induced diskinesia (1) and has antidepressant effects in women resistant to other kinds of antidepressant drug therapy (2). Moreover, changes in estro gen and progestin levels are often linked to the emotional lability associated with the premenstrual and postpartum periods (3, 4).Studies of the action of steroid honnones on the brain have progressed to a point where specific mechanisms and brain sites of action are now recognized. Especially important to the neurophannacologist are those aspects of mechanism which have begun to deal with hormonal modifica tion of properties and functions of synapses. Synaptic function and neuro transmission are indeed the common currency for the analysis of neuroendocrine events and honnone-regulated behaviors, as well as other aspects of brain function; and the study of drugs which modify neurotrans mission through blockade of synthesis, degradation, reuptake, and recep-555 0362-1642/82/0415-0555$02.00 Annu. Rev. Pharmacol. Toxicol. 1982.22:555-598. Downloaded from www.annualreviews.org Access provided by University of California -San Francisco UCSF on 02/04/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS 556 MCEWEN & PARSONStors has produced a substantial literature implicating certain neuro transmitter candidates in those neuroendocrine and behavioral events. This article will summarize both hormone (especially gonadal steroid) action on synaptic properties and functions and the neuropharmacology of two well studied hormone-regulated events, the control of feminine sexual behavior and ovulation in rodents. Out of this summary will emerge, we hope, some generalizations which will help to guide future research.

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Long-term effect of ovariectomy on dopamine-stimulated adenylate cyclase in rat striatum and nucleus accumbens

Cited by 29 publications

References 14 publications

Experimental Studies on the Development of Sex Differences in the Release of Dopamine from Striatal Tissue Fragments in vitro

Experimental Studies on the Development of Sex Differences in the Release of Dopamine from Striatal Tissue Fragments in vitro

Receptor Adaptations to Centrally Acting Drugs

Gonadal Steroid Action on the Brain: Neurochemistry and Neuropharmacology

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