Long-term effect of phacoemulsification on intraocular pressure using phakic fellow eye as control

Chang, Ta Chen; Budenz, Donald L.; Liu, Anthony; Kim, Won I.; Dang, Tam Q.; Li, Chan; Iwach, Andrew G.; Sudhakar, R.; Singh, Kuldev

doi:10.1016/j.jcrs.2012.01.016

Cited by 20 publications

(8 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both phacoemulsification and trabeculectomy techniques have evolved, which might explain why more recent papers report no differences in outcomes between trabeculectomy alone vs combined with phacoemulsification. The gelatin stent relies on a similar outflow pathway as trabeculectomy [39][40][41], but is a much less invasive procedure and provides a more controlled outflow; these factors likely explain the lack of differences between the two groups observed in our study.…”

Section: Discussionmentioning

confidence: 74%

Two-year results of a multicenter study of the ab interno gelatin implant in medically uncontrolled primary open-angle glaucoma

Reitsamer

Sng

Vera³

et al. 2019

Graefes Arch Clin Exp Ophthalmol

173

View full text Add to dashboard Cite

Purpose To evaluate the effectiveness of an ab interno subconjunctival gelatin implant as primary surgical intervention in reducing intraocular pressure (IOP) and IOP-lowering medication count in medically uncontrolled moderate primary openangle glaucoma (POAG). Methods In this prospective, non-randomized, open-label, multicenter, 2-year study, eyes with medicated baseline IOP 18-33 mmHg on 1-4 topical medications were implanted with (phaco + implant) or without (implant alone) phacoemulsification. Changes in mean IOP and medication count at months 12 (primary outcomes) and 24, clinical success rate (eyes [%] achieving ≥ 20% IOP reduction from baseline on the same or fewer medications without glaucoma-related secondary surgical intervention), intraoperative complications, and postoperative adverse events were assessed. Results The modified intent-to-treat population included 202 eyes (of 218 implanted). Changes (standard deviation) in mean IOP and medication count from baseline were − 6.5 (5.3) mmHg and − 1.7 (1.3) at month 12 and − 6.2 (4.9) mmHg and − 1.5 (1.4) at month 24, respectively (all P < 0.001). Mean medicated baseline IOP was reduced from 21.4 (3.6) to 14.9 (4.5) mmHg at 12 months and 15.2 (4.2) mmHg at 24 months, with similar results in both treatment groups. The clinical success rate was 67.6% at 12 months and 65.8% at 24 months. Overall, 51.1 (12 months) and 44.7% (24 months) of eyes were medication-free. The implant safety profile compared favorably with that published for trabeculectomy and tube shunts. Conclusions The gelatin implant effectively reduced IOP and medication needs over 2 years in POAG uncontrolled medically, with an acceptable safety profile. ClinicalTrials.gov registration number: NCT02006693 (registered in the USA).

show abstract

Section: Discussionmentioning

confidence: 74%

Two-year results of a multicenter study of the ab interno gelatin implant in medically uncontrolled primary open-angle glaucoma

Reitsamer

Sng

Vera³

et al. 2019

Graefes Arch Clin Exp Ophthalmol

173

View full text Add to dashboard Cite

show abstract

“…Chang et al . [ 10 ] reported that, in ocular hypertensive and glaucoma patients, uncomplicated phacoemulsification had no significant IOP-lowering effect compared with the phakic fellow eye for up to 3 years postoperatively and also there was no difference between the mean number of postoperative IOP-lowering medications used in the surgical and fellow eyes.…”

Section: Discussionmentioning

confidence: 99%

The effect of phacoemulsification surgery on intraocular pressure and anterior segment anatomy of the patients with cataract and ocular hypertension

Çetinkaya

Dadacı

Yener

et al. 2015

Indian J Ophthalmol

View full text Add to dashboard Cite

We evaluated the effect of phacoemulsification surgery on intraocular pressure (IOP), anterior chamber depth (ACD), iridocorneal angle (ICA), and central corneal thickness (CCT) of the patients with cataract and ocular hypertension. The decrease in IOP values of the 1st week, 1st month, 3rd month, 6th month, and 1st year was statistically significant, but that of the 2nd year was not significant. The increase in ACD and ICA values of the 1st week, 1st month, 3rd month, 6th month, and 1st year was statistically significant, but that of the 2nd year was not significant. The increase in CCT values of 1st week and 1st month was statistically significant, but those of 3rd month, 6th month, 1st year, and 2nd year were not significant. In conclusion, phacoemulsification surgery decreases IOP and increases ACD and ICA in the short-term. However, in the long-term it does not cause any significant changes.

show abstract

“…These studies were performed on patients with glaucoma and ocular hypertension. In addition, both the studies16 17 did not describe the effect of subsequent cataract extraction on IOP in the fellow eye, which we have now described. In our study, IOP of the fellow eye did not change after cataract extraction to the first surgical eye.…”

Section: Discussionmentioning

confidence: 86%

“…When surgery was subsequently performed on the fellow eye, the IOP decreased significantly to values similar to those of the first surgical eye (figure 1). The statistical phenomenon of regression to the mean has been suggested as a reason for observed IOP decrease following cataract extraction 16. Therefore, having a control fellow (non-surgical) eye group that does not similarly demonstrate a decrease in IOP compared with the first surgical eye group shows that the IOP decrease was not erroneously due to this statistical phenomenon.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of bilateral sequential cataract extraction on intraocular pressure in non-glaucomatous Asian eyes

Ngo

Tan

2015

Br J Ophthalmol

View full text Add to dashboard Cite

show abstract

Long-term effect of phacoemulsification on intraocular pressure using phakic fellow eye as control

Abstract: No author has a financial or proprietary interest in any material or method mentioned.

Cited by 20 publications

References 12 publications

Two-year results of a multicenter study of the ab interno gelatin implant in medically uncontrolled primary open-angle glaucoma

Two-year results of a multicenter study of the ab interno gelatin implant in medically uncontrolled primary open-angle glaucoma

The effect of phacoemulsification surgery on intraocular pressure and anterior segment anatomy of the patients with cataract and ocular hypertension

Effect of bilateral sequential cataract extraction on intraocular pressure in non-glaucomatous Asian eyes

Contact Info

Product

Resources

About