Long-Term Effectiveness of Bee Venom Acupuncture and Physiotherapy in the Treatment of Adhesive Capsulitis: A One-Year Follow-Up Analysis of a Previous Randomized Controlled Trial

Park, Yeon Cheol; Koh, Pil Seong; Seo, Byung-Kwan; Lee, Jung Woo; Cho, Nam Su; Park, Hyung Soon; Park, Dong Suk; baek, yong hyeon

doi:10.1089/acm.2014.0220

Cited by 29 publications

(42 citation statements)

References 18 publications

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“…In humans, however, it has been used as an anti-inflammatory medicine to relieve pain and treat chronic inflammatory diseases such as rheumatoid arthritis and multiple sclerosis [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. While bee venom itself causes nociceptive and neurotoxic effects, several recent studies have demonstrated that bee venom has radioprotective [ 8 ], antimutagenic [ 9 ], anti-inflammatory [ 7 , 10 , 11 , 12 , 13 , 14 ], anti-nociceptive [ 15 , 16 , 17 ] and anti-cancer [ 18 , 19 , 20 , 21 , 22 , 23 , 24 ] activities.…”

Section: Introductionmentioning

confidence: 99%

Bee Venom Phospholipase A2: Yesterday’s Enemy Becomes Today’s Friend

Lee

Bae

2016

Toxins

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Bee venom therapy has been used to treat immune-related diseases such as arthritis for a long time. Recently, it has revealed that group III secretory phospholipase A2 from bee venom (bee venom group III sPLA2) has in vitro and in vivo immunomodulatory effects. A growing number of reports have demonstrated the therapeutic effects of bee venom group III sPLA2. Notably, new experimental data have shown protective immune responses of bee venom group III sPLA2 against a wide range of diseases including asthma, Parkinson’s disease, and drug-induced organ inflammation. It is critical to evaluate the beneficial and adverse effects of bee venom group III sPLA2 because this enzyme is known to be the major allergen of bee venom that can cause anaphylactic shock. For many decades, efforts have been made to avoid its adverse effects. At high concentrations, exposure to bee venom group III sPLA2 can result in damage to cellular membranes and necrotic cell death. In this review, we summarized the current knowledge about the therapeutic effects of bee venom group III sPLA2 on several immunological diseases and described the detailed mechanisms of bee venom group III sPLA2 in regulating various immune responses and physiopathological changes.

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Section: Introductionmentioning

confidence: 99%

Bee Venom Phospholipase A2: Yesterday’s Enemy Becomes Today’s Friend

Lee

Bae

2016

Toxins

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“…Its biological purpose is to protect the bees from their enemies. Because of its anti-inflammatory, anti-bacterial, antimutagenic, radioprotective, anti-nociceptive immunity-promoting, hepatocyte-protective and anti-cancer characteristics [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ], it has a long history of use in folk medicine to treat various diseases. Traditionally, live bees are used to sting acupuncture points for the affected area.…”

Section: Introductionmentioning

confidence: 99%

Impact of Bee Venom Enzymes on Diseases and Immune Responses

et al. 2016

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Bee venom (BV) is used to treat many diseases and exhibits anti-inflammatory, anti-bacterial, antimutagenic, radioprotective, anti-nociceptive immunity promoting, hepatocyte protective and anti-cancer activity. According to the literature, BV contains several enzymes, including phospholipase A2 (PLA2), phospholipase B, hyaluronidase, acid phosphatase and α-glucosidase. Recent studies have also reported the detection of different classes of enzymes in BV, including esterases, proteases and peptidases, protease inhibitors and other important enzymes involved in carbohydrate metabolism. Nevertheless, the physiochemical properties and functions of each enzyme class and their mechanisms remain unclear. Various pharmacotherapeutic effects of some of the BV enzymes have been reported in several studies. At present, ongoing research aims to characterize each enzyme and elucidate their specific biological roles. This review gathers all the current knowledge on BV enzymes and their specific mechanisms in regulating various immune responses and physiological changes to provide a basis for future therapies for various diseases.

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“…Bee venom acupuncture likewise has for a long time been a traditional approach in oriental medicine for the relief of pain and inflammation. In the treatment of shoulder stiffness, bee venom acupuncture in combination with physiotherapy was shown to be beneficial compared with placebo treatment and physiotherapy, especially in improving functioning capacity and relieving pain [44,45].…”

Section: Acupuncturementioning

confidence: 99%

Shoulder Stiffness – How to Treat?

et al. 2019

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Shoulder stiffness is a condition of restricted glenohumeral range of motion, which can arise spontaneously or as consequence of a known cause, including surgical procedures on the shoulder. Several approaches to shoulder stiffness have been proposed and high-level evidence is available to analyze and discuss their results. The aim of this review was to summarize the current concepts on conservative and operative treatment of shoulder stiffness and discuss the results of the available studies with a high level of evidence, which should be considered to guide clinical practice. Treatment of shoulder stiffness should be tailored to the patientʼs clinical situation and the stage of its shoulder pathology and should aim at pain reduction, restoration of range of motion, functional regain and shortening of symptoms duration. When possible, known risk factors for primary shoulder stiffness and causes of secondary shoulder stiffness should be addressed to avoid relapse. Conservative therapy is the mainstay of treatment for shoulder stiffness and should include a multimodal and activity-oriented program. Intra-articular injection of a low dose of corticosteroid is safe and effective, provides immediate benefits, and is recommended in combination to an appropriate rehabilitation protocol. In conservative refractory cases, arthrolysis and capsular release can be performed with an arthroscopic approach.

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Long-Term Effectiveness of Bee Venom Acupuncture and Physiotherapy in the Treatment of Adhesive Capsulitis: A One-Year Follow-Up Analysis of a Previous Randomized Controlled Trial

Abstract: BVA combined with physiotherapy remains clinically effective 1 year after treatment and may help improve long-term quality of life in patients with AC of the shoulder.

Cited by 29 publications

References 18 publications

Bee Venom Phospholipase A2: Yesterday’s Enemy Becomes Today’s Friend

Bee Venom Phospholipase A2: Yesterday’s Enemy Becomes Today’s Friend

Impact of Bee Venom Enzymes on Diseases and Immune Responses

Shoulder Stiffness – How to Treat?

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