Long term effectiveness of electrochemotherapy for the treatment of lower lip squamous cell carcinoma

Gargiulo, M.; Mestre, Javier; Cortese, Antonio; Murphy, Declan C; Parascandolo, Salvatore; Razzano, Sergio

doi:10.1016/j.jcms.2018.08.013

Cited by 13 publications

(14 citation statements)

References 39 publications

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“…In this study, we present the results obtained in our series (n = 33) of malignant melanoma metastases and non-melanoma skin cancers of the HN area treated with ECT. Our findings confirm that ECT provides a degree of local control in the HN cancer in accordance with previous experiences (7,8,(12)(13)(14)(15)(16). ECT achieved an overall response in all patients with a complete response rate of 82%, a low toxicity profile and no severe side effects.…”

Section: Discussionsupporting

confidence: 92%

“…It is effective in previously irradiated areas where chemo-radiation protocols can be inapplicable (10,11). Because of its selectivity towards dividing tumour cells, when treating safety margins to decrease the risk of recurrence, it spares normal healthy tissue that surround the tumour and preserves organ functions (12,13). This is particularly important in BCC with ill-defined borders and when treating skin tumours of central facial areas where extensive surgery can be disfiguring and where there is a high risk of recurrence after excision (14)(15)(16).…”

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confidence: 99%

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Electrochemotherapy in Skin Malignancies of Head and Neck Cancer Patients: Clinical Efficacy and Aesthetic Benefits

Bonadies

Bertozzi²,

Cristiani³

et al. 2019

Acta Derm Venereol

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The main goal of skin cancer treatments is to eradicate the tumour with the safest method providing an aesthetically and functionally pleasant outcome. Electrochemotherapy is a minimal-invasive local tumour ablation procedure for cutaneous metastases. This study found that in head and neck skin cancer patients treated with electrochemotherapy, after tumour clearance and wound healing, most of the assessed scars showed physical and aesthetic characteristics very similar to those of normal surrounding area. These results suggest that in the management of head and neck skin cancer, electrochemotherapy may represent a valid alternative to traditional techniques when such techniques are not suitable. Skin malignancies of the head and neck inflict significant structural, functional, and cosmetic burdens upon those affected. We retrospectively addressed electrochemotherapy anti-tumour efficacy in head and neck skin cancer patients who were not suitable for standard treatments. Scars' physical characteristics and aesthetics were evaluated using validated scar assessment scales. Among 33 treated patients, 82% experienced a complete tumour response while 18% experienced a partial response. At a median time period of 7 months, 96% of the evaluated scars came close to resembling the normal surrounding skin showing excellent results in terms of restoration to original condition with no deformity and/or distortion and in terms of preservation of functionality, such as oral competence and eye protection. Electrochemotherapy is an effective local anticancer procedure for cutaneous tumours. In the treatment of skin malignancies of the head and neck, especially in non-surgical cases, in the elderly and in patients declining surgery, electrochemotherapy may represent a valid alternative to standard management.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Electrochemotherapy in Skin Malignancies of Head and Neck Cancer Patients: Clinical Efficacy and Aesthetic Benefits

Bonadies

Bertozzi²,

Cristiani³

et al. 2019

Acta Derm Venereol

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“…Table 1 presents the principal findings of ECT treatment in HNC [ 47 , 48 , 59 , 65 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 ]. Although the literature describing HNC do not always make clear whether the cancer location is cutaneous or mucosal, this review will focus on both cutaneous tumors and mucosal tumors (located in, or derived from, a mucosal surface, such as in the oral cavity, pharynx, larynx) in the head and neck region.…”

Section: Current Clinical Application Of Ectmentioning

confidence: 99%

“…Gargiulo et al reported the effectiveness of a single session of ECT with bleomycin in 21 patients with primary or recurrent lower lip SCC as a specific subsite, including three patients treated in the palliative setting and four patients who received surgery following ECT. The OR rate following a single session of ECT was 100%, with CR in 71.4% and PR in 28.6% of patients [ 87 ].…”

Section: Current Clinical Application Of Ectmentioning

confidence: 99%

Electrochemotherapy in the Treatment of Head and Neck Cancer: Current Conditions and Future Directions

Enokida¹,

Tahara²

2021

Cancers

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Despite recent advances in the development of chemotherapeutic drug, treatment for advanced cancer of the head and neck cancer (HNC) is still challenging. Options are limited by multiple factors, such as a prior history of irradiation to the tumor site as well as functional limitations. Against this background, electrochemotherapy (ECT) is a new modality which combines administration of an antineoplastic agent with locally applied electric pulses. These pulses allow the chemotherapeutic drug to penetrate the intracellular space of the tumor cells and thereby increase its cytotoxicity. ECT has shown encouraging efficacy and a tolerable safety profile in many clinical studies, including in heavily pre-treated HNC patients, and is considered a promising strategy. Efforts to improve its efficacy and broaden its application are now ongoing. Moreover, the combination of ECT with recently developed novel therapies, including immunotherapy, represented by immune checkpoint inhibitor (ICI)s, has attracted attention for its potent theoretical rationale. More extensive, well-organized clinical studies and timely updating of consensus guidelines will bring this hopeful treatment to HNC patients under challenging situations.

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“…In these patients, ECT may represent a low-invasive option with unique advantages in terms of hospitalization, tissue preservation, and costs [170,180,187] . Some have proposed administering ECT with neoadjuvant and/or curative intent in patients with small size cancers of the lower lip, tongue, and palate [173,188] . Treatment of these tumors is challenging, due to anatomic constraints, and possible side effects.…”

Section: Head and Neck Cancermentioning

confidence: 99%

Electrochemotherapy of superficial tumors – Current status:

Campana

Miklavčič

Bertino

et al. 2019

Seminars in Oncology

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Long term effectiveness of electrochemotherapy for the treatment of lower lip squamous cell carcinoma

Cited by 13 publications

References 39 publications

Electrochemotherapy in Skin Malignancies of Head and Neck Cancer Patients: Clinical Efficacy and Aesthetic Benefits

Electrochemotherapy in Skin Malignancies of Head and Neck Cancer Patients: Clinical Efficacy and Aesthetic Benefits

Electrochemotherapy in the Treatment of Head and Neck Cancer: Current Conditions and Future Directions

Electrochemotherapy of superficial tumors – Current status:

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