2017
DOI: 10.1038/srep44821
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Long-term effectiveness of irreversible electroporation in a murine model of colorectal liver metastasis

Abstract: Irreversible electroporation (IRE) has recently gained in popularity as an ablative technique, however little is known about its oncological long-term outcomes. To determine the long-time survival of animals treated with a high dose of IRE and which histological changes it induces in tumoral tissue, IRE ablation was performed in forty-six athymic-nude mice with KM12C tumors implanted in the liver by applying electric current with different voltages (2000 V/cm, 1000 V/cm). The tumors were allowed to continue to… Show more

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Cited by 10 publications
(12 citation statements)
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“…Our group recently studied the long-term effectiveness of treating a large amount of healthy hepatic tissue harbouring an implanted tumour with parallel transhepatic electrodes. 15 In this study we showed that even with high electrical fields (up to 2000 V/cm) complete eradication of the tumour was infrequent even when massive destruction of nearby healthy hepatic tissue was present (expressed by life-threating ionic imbalances). 16 …”
Section: Introductionmentioning
confidence: 64%
“…Our group recently studied the long-term effectiveness of treating a large amount of healthy hepatic tissue harbouring an implanted tumour with parallel transhepatic electrodes. 15 In this study we showed that even with high electrical fields (up to 2000 V/cm) complete eradication of the tumour was infrequent even when massive destruction of nearby healthy hepatic tissue was present (expressed by life-threating ionic imbalances). 16 …”
Section: Introductionmentioning
confidence: 64%
“…IRE is a comparatively novel non-thermal ablation technology which can induce tumour necrosis while sparing adjacent vulnerable structures. Emerging small data series support IRE’s safety and effectiveness in the liver [710].…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, through IRE’s non-thermal mechanism which avoids heat sink and its ability to reduce collateral damage, it has been suggested as an alternative ablative technology in the liver [6]. Pre-clinical studies in animals have confirmed IRE’s ability to induce tumour necrosis while sparing adjacent vulnerable structures and support its safety and effectiveness [710]. IRE is commercially available for human treatment as NanoKnife (AngioDynamics, New York, USA).…”
Section: Introductionmentioning
confidence: 99%
“…The role of FUT8 in BC via blood metastasis to liver was investigated by dividing tumors into small pieces, and s.c. injecting a standard volume (2 mm 3 ) of tumor debris in spleens of healthy 4‐ to 6‐week‐old BALB/c‐nu mice as described previously. 16 After 4 weeks, mice were euthanized, and tumors were excised and weighed.…”
Section: Methodsmentioning
confidence: 99%