Long-term effectiveness of Radiofrequency Ablation for solitary small Hepatocellular Carcinoma: A retrospective analysis of 363 patients

Microvascular invasion predicts a poor prognosis of solitary hepatocellular carcinoma up to 2 cm based on propensity score matching analysis

“…Furthermore, along with the progress of surgical techniques, growing evidence shows that 3 cm should be defined as the cutoff point for very early stage HCC. [41][42][43] It is still essential to explore the most rational cut-off value among largescale HCC patients.…”

NCCN Guidelines Insights: Hepatobiliary Cancers, Version 1.2017

“…20–22 Results of some long-term studies show survival rates of >50% at 5 years for patients with early-stage HCC treated with RFA. 23–26 However, the reported OS and recurrence rates vary widely across studies for patients treated with RFA, which is most likely due to differences in the size and number of tumors and, perhaps more importantly, tumor biology and the extent of underlying liver function. In multivariate analysis, Child-Pugh class, tumor size, and tumor number were independent predictors of survival.…”

“…In multivariate analysis, Child-Pugh class, tumor size, and tumor number were independent predictors of survival. 24–26 …”

Longterm survival outcomes of patients undergoing treatment with radiofrequency ablation for hepatocellular carcinoma and metastatic colorectal cancer liver tumors

“…Liver function and alpha fetoprotein level strongly influence survivals in patients with HCC. 24 Berber at al reported that patients with a carcinoembryonic antigen (CEA) less than 200 ng/ mL has an improved overall survival compared with those with a CEA more than 200. 17 Furthermore, patients with dominant lesion less than 3 cm in diameter had a median survival of 38 versus 34 months for lesions 3-5 cm, and 21 months for lesions greater than 5 cm (P = .03).…”