Long-term effectiveness of the nine-valent human papillomavirus vaccine in Scandinavian women: interim analysis after 8 years of follow-up

Kjær, Susanne K.; Nygård, Mari; Sundström, Karin; Munk, Christian; Berger, Sophie; Džabić, Mensur; Fridrich, Katrin; Waldstrøm, Marianne; Sørbye, Sveinung Wergeland; Bautista, Oliver; Luxembourg, Alain

doi:10.1080/21645515.2020.1839292

Cited by 37 publications

(27 citation statements)

References 15 publications

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“…Besides, the immunogenicity results of a long-term study on quadrivalent vaccine have indicated sustained antibody responses against genotypes 6, 11, 16 and 18 up to fourteen years after immunization [19]. These conclusions are in line with the excellent results of an interim analysis (follow-up at 8 years) carried out on Scandinavian women vaccinated with the nonavalent vaccine; this analysis has confirmed the absence of high-grade lesions caused by the genotypes included in the vaccine in immunized women and the persistence over time of efficacy [19,20].…”

Section: Vaccines Available In Europe and Italy Primary Target Schedule And Differences Between Italian Regionssupporting

confidence: 67%

Human Papilloma Virus Vaccination: Focus on the Italian Situation

et al. 2021

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Human papilloma virus (HPV) is a viral agent whose transmission occurs mainly by sexual means. It causes different pathological conditions in both males and females, ranging from benign pathologies up to cancers. The introduction of vaccination has certainly had a major impact in terms of reducing the incidence of both HPV infections and diseases but in the European Union and the European Economic Area (EU/EEA) there are still about more than 13,000 deaths due to cervical cancer each year. To date in Europe and in Italy there are three vaccines available (bi-, tetra-, and nonvalent vaccines). The vaccination campaign started irregularly in Europe and Italy in 2007, with pre-adolescent girls as the primary target. Later, other cohorts were introduced such as 12-year-old boys, additional cohorts of >25-year-old women, women who already underwent cervical surgery and other subjects entitled to free vaccination. The COVID-19 pandemic has strongly impacted on public health services, particularly on vaccinations that, especially during the first pandemic phase, have been often delayed and/or canceled. The most affected vaccinations by the pandemic have been the non-mandatory ones, particularly those addressing the adolescent and adult population, such as immunization against papillomavirus. To date the achievement of the coverage target set by the Italian National Immunization Plan (NIP) has not yet been achieved. The aim of this work is to summarize the current situation in Italy and to discuss the strategies that have been implemented to increase overall vaccination coverage rates.

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Section: Vaccines Available In Europe and Italy Primary Target Schedule And Differences Between Italian Regionssupporting

confidence: 67%

Human Papilloma Virus Vaccination: Focus on the Italian Situation

et al. 2021

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“…The observation periods for the 9-valent vaccine was 5 years in a Latin American study [52], 6 years in the extension V503-001 [53], 8 years in a Scandinavian study [55] and 8 years in the LTFU extension study [54].…”

Section: -Valent Vaccine 431 Young Womenmentioning

confidence: 99%

Long-Term Effects of Human Papillomavirus Vaccination in Clinical Trials and Real-World Data: A Systematic Review

et al. 2022

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The preventive effect of HPV vaccines against anogenital and oropharyngeal cancers has been proven in both clinical trials and real-world data. We reviewed the published evidence about the long-term efficacy and effectiveness of the HPV vaccine in available papers of clinical trials and real-world data. As far as we searched, the longest period of preventive effect for the bivalent, 4-valent, and 9-valent vaccine were 11 years in the Costa Rica trial, 14 years in the FUTURE II, and 8 years in the LTFU extension study of V503-002 and the Scandinavian study, respectively. The sustained clinical effect during the observation period was longest for the 4-valent vaccine. In real-world data, the longest observation period of the vaccine effectiveness was 12 years in an Australian study for the 4-valent vaccine. On the other hand, the longest period of long-term persistence of HPV vaccine-induced seropositivity was 14 years in FUTURE II for the 4-valent vaccine. For the bivalent vaccine, additional long-term follow-up studies may not have been planned due to the launch of the 4-valent and 9-valent vaccines. In some studies of the 9-valent vaccine, the results have not yet been published because of the short observation period. The additional results are expected in the future. In a national immunization program, most girls and boys are inoculated with HPV vaccine by the time puberty begins; thus, it is important to monitor the vaccine effect at least until the sexually active period in their 20s and 30s.

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“…Kürzlich ist der ultimative Beweis geliefert worden, dass durch die HPV-Impfung nicht nur Infektionen und Krebsvorstufen, sondern auch invasive Karzinome verhindert werden [10,11]. Dies ist ein Meilenstein und global ist das Zervixkarzinom nach wie vor eines der häufigsten Karzinome.…”

Section: Diskussionunclassified

Warum ist die HPV-Impfung von Jungen sinnvoll?

Joura

2021

Gynäkologe

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ZusammenfassungUrsprünglich als Impfung gegen Gebärmutterhalskrebs geplant, haben HPV(humane Papillomviren)-Impfungen unsere Erwartungen weit übertroffen. Sie haben das Potenzial, bei Frauen und Männern mindestens 6 Karzinomtypen, deren Vorstufen sowie Genitalwarzen zu verhindern und sogar zu eliminieren. Nach 14 Jahren Anwendung wissen wir, dass HPV-Impfprogramme hocheffektiv sind, frühe Impfung und eine gute Durchimpfungsrate sind wesentlich. Geschlechtsneutrale Impfungen verdoppeln potenziell die Durchimpfungsrate. Das ist vor allem in Ländern mit einer Durchimpfungsrate von < 70 % zur Erlangung eines Herdenschutzes von Bedeutung. Oropharyngeale Karzinome nehmen immer mehr zu, betreffen vor allem Männer und werden durch HPV 16 verursacht. Ebenso werden das Anal- und das Peniskarzinom durch HPV hervorgerufen und sind daher vermeidbar. Ein geschlechtsneutrales HPV-Impfprogramm schützt alle – auch homosexuelle – Männer direkt.

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Long-term effectiveness of the nine-valent human papillomavirus vaccine in Scandinavian women: interim analysis after 8 years of follow-up

Cited by 37 publications

References 15 publications

Human Papilloma Virus Vaccination: Focus on the Italian Situation

Human Papilloma Virus Vaccination: Focus on the Italian Situation

Long-Term Effects of Human Papillomavirus Vaccination in Clinical Trials and Real-World Data: A Systematic Review

Warum ist die HPV-Impfung von Jungen sinnvoll?

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