Past educational reforms were commonly found to be of limited success, due to the fact that schools alone cannot overcome the developmental challenges that poverty and ethno-cultural segregation impose upon many children. However, there are reports of some reform programs that have frequently been successful in low-achieving, poverty-ridden, and ethno-culturally segregated schools. In this paper, two such successful school reform programs-School Development Program; Child Development Project-were examined in order to identify processes linked to their frequent success, with a focus on the implementation and sustainability of these programs. The analysis was theoretically guided by Bronfenbrenner's bio-ecological theory of human development. A web of interdependent processes, related to relationship building, autonomy, resistance to change, competence, leadership, team support, and school-family-community partnerships, was identified. These findings are discussed in regard to a conceptual and practical shift in school reform: (a) towards schools as caring communities that address universal human needs in culturally appropriate ways, with accountability tied to providing continuity and support to empowered students; and (b) away from schools that universally focus on narrow, externally imposed, and discriminatory outcome goals.