Long-term effects of a ketogenic diet on body composition and bone mineralization in GLUT-1 deficiency syndrome: A case series

Bertoli, Simona; Trentani, Claudia; Ferraris, Cinzia; Giorgis, Valentina De; Veggiotti, Pierangelo; Tagliabue, Anna

doi:10.1016/j.nut.2014.01.005

Cited by 49 publications

(34 citation statements)

References 20 publications

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“…It is reassuring that a 12-wk KD did not worsen the height and weight for age percentiles; these results confirm our previous observations on the lack of adverse KD effects on nutritional status [1,34]. We suppose that our positive results are due to the accurate assessment of the energy needs of the children (obtained by repeated measurement of REE and assessment of daily physical activity levels), and to the strong and continuous support to caregivers in the management of KD treatment.…”

Section: Discussionsupporting

confidence: 87%

Short-term effects of ketogenic diet on anthropometric parameters, body fat distribution, and inflammatory cytokine production in GLUT1 deficiency syndrome

et al. 2015

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Section: Discussionsupporting

confidence: 87%

Short-term effects of ketogenic diet on anthropometric parameters, body fat distribution, and inflammatory cytokine production in GLUT1 deficiency syndrome

et al. 2015

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“…Two studies found that the diets interfered with social interaction in adolescents,23 24 although none found that parental stress increased 14. Despite reports of loss of bone mass25 or mineral content26 in children, a case series found no negative effects on bone mineral content or density in three adults with glucose transporter 1 deficiency syndrome who had followed the diets for >5 years 27…”

Section: Tolerabilitymentioning

confidence: 97%

Ketogenic dietary therapies in adults with epilepsy: a practical guide

Schoeler¹,

Cross²

2016

Pract Neurol

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“…A number of researchers may be more concerned about how the long‐term treatment with a KD will affect the growth curve, resulting in application concerns. Numis, Yellen, Chu‐Shore, Pfeifer, and Thiele () reported that the growth curve is not affected by the KD, but three females with GLUT1 deficiency who were treated with a KD for 5 years showed that the bone mineral content and bone mineral density were not negatively affected (Bertoli et al., ). Adverse reactions should be given full attention, and effective measures should be taken for prevention and/or intervention.…”

Section: Discussionmentioning

confidence: 99%

Ketogenic diet effects on 52 children with pharmacoresistant epileptic encephalopathy: A clinical prospective study

Wang

Fan

et al. 2018

Brain and Behavior

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ObjectiveTo evaluate the clinical impact of ketogenic diet (KD) on children with pharmacoresistant epileptic encephalopathy.MethodsIn all, 52 children with pharmacoresistant epileptic encephalopathy that diagnosed in our hospital from July 2012 to June 2015 were selected, including West syndrome 38 cases, Lennox–Gastaut Syndrome 7 cases, Doose Syndrome 1 case, and Dravet syndrome 6 cases, and the effect, compliance, adverse reactions, electroencephalogram (EEG), and cognitive function were analyzed. Modified Johns Hopkins protocol was used to initiate KD, and Engel scale was used to evaluate the effect, and evaluated the effect of KD on the cognition, language, and motor function.ResultsAt 12 weeks of KD treatment, the patients achieved I, II, III, and IV grade effect were accounted for 26.9% (14/52 cases), 17.3% (9/52 cases), 11.5% (6/52 cases), and 44.2% (23/52 cases), respectively, according to Engel scale. KD has different effect on different epileptic syndromes, best effect on Doose syndromes of 100%, and better effect on West syndrome with the effect rate of 57.9%, and the total effect number was 22 cases. The reduction of epileptiform discharges in the awake state before KD treatment was correlated with the seizure time after 3 months of KD treatment (r = .330, p = .017). The cognitive function of 23 patients was improved, 12 patients had language improvement, and the motor function was improved in 10 patients. In all, 23 patients had adverse reactions, and all patients were tolerated and improved.Conclusion KD has certain effect on children with pharmacoresistant epileptic encephalopathy, and it can reduce interictal epileptic discharge frequency, and improve the background rhythm of EEG. The reduction of epileptiform discharges in awake state is in favor of the reduction of seizures frequency, thus increasing the efficacy, and improve the cognitive function, language, and motor function to varying degrees, combined with less adverse reaction, which is worthy of clinical application.

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Long-term effects of a ketogenic diet on body composition and bone mineralization in GLUT-1 deficiency syndrome: A case series

Cited by 49 publications

References 20 publications

Short-term effects of ketogenic diet on anthropometric parameters, body fat distribution, and inflammatory cytokine production in GLUT1 deficiency syndrome

Short-term effects of ketogenic diet on anthropometric parameters, body fat distribution, and inflammatory cytokine production in GLUT1 deficiency syndrome

Ketogenic dietary therapies in adults with epilepsy: a practical guide

Ketogenic diet effects on 52 children with pharmacoresistant epileptic encephalopathy: A clinical prospective study

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