Long Term Effects of Amlodipine on Renal Haemodynamics and Microalbuminuria in Patients with Essential Hypertension

Perinotto, P; Ragni, G; Serventi, M.; Giberti, Daniela; Tateo, Enrico; Calzolari, Massimo; Giucastro, Giuliano; Buzio, Carlo; Montanari, Alberto

doi:10.2165/00044011-199700131-00008

Cited by 3 publications

(2 citation statements)

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“…It was agreed to a randomised double blind non-inferiority trial done in Taiwan 40 and in Italy where significant rise was recorded after amlodipine was initiated. 41 Fractions of filtration rates in the current study had improved with similar fashions to Taiwan and…”

Section: Discussionsupporting

confidence: 63%

“…Generally, it is believed that chronic CCBs treatment would maintain reasonably pronounced and sustained afferent renal vasodilatations, which further results an improved in GFRs. 41 Moreover, it might be due to different study designs, the former studies used controlled study designs that potentially handled possible confounders, compliance issues; and the purposes of the data recordings all these could prevent the overestimated eGFR values. Besides, these factors might be the reasons for higher filtration fraction rates levels observed in the current study.…”

Section: Open Accessmentioning

confidence: 99%

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Renal outcomes of diabetic patients treated with combination therapy of ACE inhibitors plus either thiazide diuretics or calcium channel blockers: comparative retrospective cohort study in Northwestern Ethiopia

et al. 2021

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ObjectiveThe study determined the comparative renal functions on patients with diabetes treated with ACE inhibitors (ACEIs) plus either thiazide diuretics or calcium channel blockers (CCBs) in Northwestern Ethiopia.DesignRetrospective cohort study design was employed to collect the data from medical records of patients with diabetes followed for 1–5 years (N=404).SettingThe medical records of patients in chronic diabetic follow-up clinics of the hospital.ParticipantsAll the patients with diabetes medical records in Northwestern Ethiopian specialised hospital.Main outcome measuresExposures were ACEIs plus thiazide diuretics or CCBs collected from March to June 2020. Outcomes were defined as declining in estimated glomerular filtration rate (eGFR) values by ≥30% from the baseline recorded from 2015 to 2019. Descriptive and analytical statistics were illustrated to compare the study groups. Kaplan-Meier with log- rank test was used to plot the survival analyses curve. Potential factors substantially associated to renal events were examined using cox proportional hazards model.ResultAbout 20% of patients developed renal events and significant numbers were from hydrochlorothiazide (HCT) users. The mean eGFR levels were significantly higher in patients on CCBs users over the follow-up years compared with HCT-based users. The CCBs users had an 18.8 mL/min/1.73 m2 higher in eGFR levels at the end of the follow-up period than HCT users (p<0.001). HCT users had shorter survival probability overtime to develop the outcomes compared with CCBs users (p=0.003). The CCBs-based regimen prevented risks of declining in renal function by 56.4% than HCT (p=0.001). Hazards of declining in eGFR levels were 93% higher for the patients with initial systolic blood pressure (SBP) levels were more than 150 mm Hg (p=0.006).ConclusionCompared with HCT, patients on CCBs had significantly prevented risks of renal events. However, both groups appeared with the same cardiovascular events. HCT-based regimen and higher initial SBP levels were significantly associated with eGFR reductions.

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Section: Discussionsupporting

confidence: 63%

Section: Open Accessmentioning

confidence: 99%