Long‐term effects of an oral elemental nutritional supplement on post‐gastrectomy body weight loss in gastric cancer patients (KSES002)

Kimura, Yutaka; Nishikawa, Kazuhiro; Kutsukake, Kentaro; Inoue, Kentaro; Matsuyama, Jin; Akamaru, Yusuke; Tamura, Shigeyuki; Kawada, Junji; Kawase, Takakazu; Kawabata, Ryohei; Fujiwara, Yoshiyuki; Kanno, Hitoshi; Yamada, Takeshi; Shimokawa, Toshio; Imamura, Hiroshi

doi:10.1002/ags3.12290

Cited by 36 publications

(36 citation statements)

References 34 publications

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“…Recent studies showed that oral nutritional supplements significantly improved postoperative weight loss in GC patients 29,30 . In the same way, another study showed that exercise interventions prevented postoperative muscle loss in GC patients 31 .…”

Section: Discussionmentioning

confidence: 90%

The clinical influence of the preoperative lymphocyte‐to‐monocyte ratio on the postoperative outcome of patients with early‐stage gastrointestinal cancer

Shioiri

Ishizuka

Sakai

et al. 2020

Annals of Gastroent Surgery

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Aim: The lymphocyte-to-monocyte ratio (LMR) is useful for predicting the prognosis of patients with gastric cancer (GC) and those with colorectal cancer (CRC) undergoing surgery. The relationship between the LMR and postoperative outcome of patients with early-stage gastrointestinal cancers such as stage I GC and CRC remains unclear. Methods: We retrospectively evaluated 323 stage I GC and 152 stage I CRC patients undergoing surgery. Univariate and multivariate analyses using the Cox proportional hazards model were performed to identify the clinical characteristics associated with overall survival (OS), and the cutoff values of these variables were determined by receiver operating characteristic analysis. The Kaplan-Meier method and log-rank test were used for postoperative survival comparisons according to the LMR (GC: LMR < 4.2 vs ≥4.2; CRC: LMR < 3.0 vs ≥3.0). Results: Univariate and multivariate analyses revealed that OS was significantly associated with the LMR (<4.2/≥4.2) (HR, 2.489; 95% CI, 1.317-4.702; P = 0.005), as well as age (>75/≤75 years) (HR, 3.511; 95% CI, 1.881-6.551; P < 0.001) and albumin level (≤3.5/>3.5 g/dL) (HR, 3.040; 95% CI, 1.575-5.869; P = 0.001), in stage I GC patients. Survival analysis demonstrated a significantly poorer OS in stage I GC patients with a LMR < 4.2 compared with ≥4.2 (P < 0.001). In stage I CRC patients, despite a significant difference in OS according to the LMR (<3.0 vs ≥3.0) (P = 0.040), univariate analysis revealed no significant association between the LMR and OS. Conclusion: LMR is a useful predictor of the postoperative outcome of stage I GC patients treated surgically. K E Y W O R D S immunosuppression, lymphocyte-to-monocyte ratio, stage I colorectal cancer, stage I gastric cancer This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 90%

The clinical influence of the preoperative lymphocyte‐to‐monocyte ratio on the postoperative outcome of patients with early‐stage gastrointestinal cancer

Shioiri

Ishizuka

Sakai

et al. 2020

Annals of Gastroent Surgery

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“…Preoperative nutritional and exercise interventions for gastric cancer may be useful in improving postoperative outcomes [ 42 ]. However, few reports have focused on the effects of postoperative nutritional or rehabilitative interventions on the postoperative development of sarcopenia and outcomes [ 43 ]. Postoperative nutritional management and regular exercise may be important for the maintenance of SMM and nutritional status at the time of gastric cancer recurrence in patients at a high risk of recurrence after gastrectomy.…”

Section: Discussionmentioning

confidence: 99%

Impact of skeletal muscle mass in patients with recurrent gastric cancer

Matsunaga

Satio²,

Miyauchi

et al. 2021

World J Surg Onc

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Background We retrospectively examined the relationship among skeletal muscle mass index (SMI), prognosis, and chemotherapy side effects in patients with recurrent gastric cancer (RGC). Methods Sixty-seven patients who developed recurrence after undergoing curative gastrectomy for gastric cancer at Tottori University Hospital and received palliative chemotherapy were included in this study. Pretreatment computed tomography was performed to measure the skeletal muscle mass (SMM) and cross-sectional SMM at the third lumbar vertebra. We focused on haematologic toxicity (neutropenia, thrombocytopenia, and anaemia), febrile neutropenia, and gastrointestinal toxicity (diarrhoea, vomiting, and stomatitis) as the side effects of chemotherapy. Results Median SMIs for males and females (43.9 and 34.7 cm2/m2, respectively) were used as cutoff values. The patients were classified into high (SMIHigh; n = 34) and low SMI groups (SMILow; n = 33). The SMILow group included more patients treated with monotherapy (P = 0.016) compared with the SMIHigh group, had a significantly lower number of chemotherapy lines (P = 0.049), and had a significantly higher incidence of grade 3 or 4 side effects (P = 0.010). The median survival rate was significantly higher in the SMIHigh group (17.8 vs 15.8 months; P = 0.034). In the univariate analysis, body mass index, SMI, histological type, and prognostic nutritional index were identified as prognostic indicators. The multivariate analysis identified SMI (P = 0.037) and histological type (P = 0.028) as independent prognostic factors. Conclusion The incidence of grade 3 or 4 side effects was significantly higher in patients with SMILow RGC. SMI was a useful prognostic marker of RGC.

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“…Recently, oral nutritional supplements (ONS) have been of great interest as perioperative nutritional interventions in patients with GC who underwent gastrectomy. Kimura et al demonstrated that administration of 300 kcal/day of ONS for 6 to 8 weeks in the early post-gastrectomy period reduced body weight loss not only at 6 to 8 weeks postoperatively but also at 1 year in patients who underwent TG [7]. Therefore, nutritional support might be useful in preventing readmission due to nutritional di culty.…”

Section: Discussionmentioning

confidence: 99%

“…Although the causes of readmission varied among patients who underwent gastrectomy for GC, nutritional di culty was again one of the main causes of readmission in these patients. Recent studies have demonstrated that planned nutritional support could improve the nutritional status of patients who underwent gastrectomy for GC [6,7]. Therefore, it might be possible to avoid readmission due to nutritional di culty by intensive nutritional support in these patients.…”

Section: Introductionmentioning

confidence: 99%

The Type of Gastrectomy and Modified Frailty Index as Useful Predictive Indicators for One-Year Readmission Due to Nutritional Difficulty in Patients Who Undergo Gastrectomy for Gastric Cancer.

Osaki¹,

Saito²,

Miyauchi³

et al. 2021

Preprint

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Background Patients who undergo gastrectomy for gastric cancer are likely to have nutritional difficulty after surgery. Therefore, readmission due to nutritional difficulty is frequently observed in such patients. This study aimed to identify predictive indicators for readmission due to nutritional difficulty in patients who underwent gastrectomy for gastric cancer. Methods We retrospectively reviewed surgical outcomes in 516 consecutive patients who underwent gastrectomy for gastric cancer. Results The readmission rate within one year was 13.8%. Readmission due to nutritional difficulty was observed in 20 patients (3.9%), and nutritional difficulty was the second leading cause of readmission. Multivariate analysis revealed that the type of gastrectomy and the modified frailty index were independent predictive indicators of readmission due to nutritional difficulty. The readmission rates due to nutritional difficulty were 1.2%, 4.7%, and 11.5% in patients who underwent distal partial gastrectomy and had low modified frailty index, in those who underwent distal partial gastrectomy and had high modified frailty index or those who underwent either proximal partial or total gastrectomy and had low modified frailty index, and in those who underwent either proximal partial or total gastrectomy and had high modified frailty index, respectively (P = 0.0008). Conclusions Because the readmission rate due to nutritional difficulty is high in patients who underwent either total or proximal partial gastrectomy with high modified frailty index, intensive follow-up and nutritional support is needed to reduce readmission due to nutritional difficulty, which can help improve the patients’ quality of life and reduce additional medical costs.

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Long‐term effects of an oral elemental nutritional supplement on post‐gastrectomy body weight loss in gastric cancer patients (KSES002)

Cited by 36 publications

References 34 publications

The clinical influence of the preoperative lymphocyte‐to‐monocyte ratio on the postoperative outcome of patients with early‐stage gastrointestinal cancer

The clinical influence of the preoperative lymphocyte‐to‐monocyte ratio on the postoperative outcome of patients with early‐stage gastrointestinal cancer

Impact of skeletal muscle mass in patients with recurrent gastric cancer

The Type of Gastrectomy and Modified Frailty Index as Useful Predictive Indicators for One-Year Readmission Due to Nutritional Difficulty in Patients Who Undergo Gastrectomy for Gastric Cancer.

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