Long-term effects of first degree family history of breast cancer in young women: Recurrences and bilateral breast cancer

Abstract

Background. The aim of this study is to analyze the impact of first degree relative (FDR) of young breast cancer patients. Methods. Data were used from our prospective population-based cohort study which started in 1983. The family history (FH) was registered with regard to FDR: the presence or absence of invasive breast cancer in none vs. one or more FDRs at any age. Results. A total of 1109 women, 50 years with 1128 breast conserving treatments was seen. The incidence of FDR was 17.0% for one FDR and 3.2% 2 FDR. The three groups, none, 1 or 2 FDR, were comparable. The local failure rate is comparable for all three groups. Women with a positive FH and metachronous bilateral breast cancer (MBBC) showed a lower local failure (HR 0.2; 95% CI 0.05-0.8). A positive FH was an independent predictor for a better disease-specific survival (HR 0.6; 95% CI 0.4-0.9). Conclusion. A positive FH, based on FDR implies a better prognosis in relation to survival for young women treated with BCT. In contrast to no FH for FDR, MBBC in women with a positive FH was not associated with an increased risk of local recurrence.

Family history of breast cancer and its association with disease severity and mortality

“…A study incorporating Utah's Population Database found that women under the age of 50 with a family history of BC were statistically significantly at a greater risk of a poorer survival when compared to those women without; with a relative risk of 1.54 (95% CI: 0.98–2.41) for women with first degree relatives previously diagnosed with BC . In contrast, a recent population‐based study based in Netherlands reported a lower risk of all‐cause death with ≥2 first‐degree relative with family history (HR 0.2; 95% CI 0.06–1.0). Nevertheless, several studies have found no association between family history and BC overall survival .…”

Clonal evolution characteristics and reduced dimension prognostic model for non-metastatic metachronous bilateral breast cancer

“…Recently, majority of studies focused on the risk factors for the formation of contralateral breast cancer (CBC) in patients with primary breast cancer (PBC) ( 5 ) and expected to prevent the occurrence of CBC via bilateral mastectomy ( 6 , 7 ), whereas, for clinical practice, it is not yet clear whether patients would benefit from bilateral mastectomy in terms of mortality ( 6 ). More importantly, once diagnosed as CBC, how to develop overall treatment strategies and evaluate the prognosis of these MBBC remains confused in clinical ( 8 – 11 ). Actually, most clinical understanding of MBBC is obviously distinct from unilateral breast cancer (UBC) ( 12 , 13 ).…”

Clonal Evolution Characteristics and Reduced Dimension Prognostic Model for Non-Metastatic Metachronous Bilateral Breast Cancer

“…While for clinical practice, it is not yet clear whether patients would benefit from bilateral mastectomy in terms of mortality (5). More importantly, once diagnosed as CBC, how to develop overall treatment strategies and evaluate the prognosis of these MBBC remains confused in clinical (7)(8)(9)(10)32). Actually, most clinical understanding of MBBC is obviously distinct from unilateral breast cancer (UBC) (11,12), and it is urgently needed to build an evaluation model for predicting the prognosis of MBBC.…”