Long‐term effects of injection laryngoplasty with a temporary agent on voice quality and vocal fold position

Abstract

The lower rate of permanent ML in patients undergoing temporary IL corresponds with improvements in CAPE-V scores and laryngoscopic features. Improvements persisted beyond the accepted time frame for temporary graft resorption.

Early hyaluronate injection improves quality of life but not neural recovery in unilateral vocal fold paralysis: An open-label randomized controlled study

“…Friedman et al hypothesized that long-term voice improvement after temporary agent injection may result from vibro-tactile stimulation induced by physical contact of mobile counter cords, i.e., early temporary agent injection increased sensory stimulation of the paralyzed vocal cords, resulting in better vocal-fold positioning (Friedman, 2010). Prendes et al (Prendes, 2012) evaluated voice in UVFP patients using the Consensus Auditory-Perceptual Evaluation of Voice and found that voice at the final assessment was better in patients who received temporary agent injection. However, this was in contrast to our study, which showed comparable voice improvements in the two groups.…”

“…In the present study, voice and quality of life measurements improved immediately after hyaluronate injection and persisted for 6 months. However, the long-term effect of single injection of a temporary agent remains questionable (Friedman, 2010;Prendes, 2012;Yung, 2011). In a cohort study, Friedman et al showed that 63% of patients who received hyaluronate injection within 6 months of symptom onset remained in adequate voice at long-term follow-up (Friedman, 2010).…”

“…In a cohort study, Friedman et al showed that 63% of patients who received hyaluronate injection within 6 months of symptom onset remained in adequate voice at long-term follow-up (Friedman, 2010). In addition, early hyaluronate injection decreased the need for transcervical medialization laryngoplasty in patients with UVFP (Friedman, 2010;Prendes, 2012). However, no randomized controlled study has addressed this question and no comprehensive evaluation of the effects of hyaluronate injection, involving quantitative recruit-ment analysis, vocal cord position, voice, and quality of life, has yet been made.…”

What We Have Learned About Soft-Tissue Augmentation Over the Past 10 Years

“…In a study by Wise et al, 6 mADG was injected subdermally into the palate of Yorkshire minipigs, and rapid clinical resorption was noted, while an intense lymphocytic infiltrate was seen around residual ADG material. However, we also noted rapid loss of clinical volume when ADG was injected subdermally, 3 and a similar lymphocytic response was noted when sheet ADG was implanted into rabbits. 7 Since minimal lymphocytic response was noted in the human biopsy specimens taken over the first year after implantation, this likely represents an immune response to a xenograft.…”

Manejo De Disfonía Post Cirugía Tiroidea Con Laringoplastía Por Inyección Con Ácido Hialurónico

“…De éstos, el 34% lo hace con movilidad cordal parcial o total y el 38% lo logra sin recuperación de movilidad cordal gracias a un reposicionamiento de la cuerda vocal en la línea media. Ahora si este mismo grupo de pacientes sólo lo observamos sin realizar ninguna intervención en el mismo período de 9 meses, el 67% de ellos no logra una voz adecuada y requiere una tiroplastía de medialización para corregir su voz [18][19][20] . Comunicamos este caso por la alta frecuencia de disfonía post cirugía tiroidea.…”