Long-term effects of intravitreal ranibizumab treatment on retinal ganglion cell complex and choroidal thickness

Çakir, Akın; Sağdiç, Sercan Koray; Düzgün, Eyüp; Erden, Burak; Ayata, Ali; Ünal, Melih

doi:10.15761/nfo.1000197

Cited by 2 publications

(2 citation statements)

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“…In a previous study conducted by Cakır et al,32 eyes in 27 patients with classic choroidal neovascularization who had undergone intravitreal 0.5 mg ranibizumab injections with a minimum of a 2-year follow up were enrolled as the study group. They reported that long-term IVR treatment was associated with significant reductions in the ganglion cell layer and internal plexiform layer thicknesses [25] . In another study, SFCT seemed to decrease after intravitreal bevacizumab injections in eyes with neovascular age-related macular degeneration as compared to untreated eyes with the same condition [26] .…”

Section: Discussionmentioning

confidence: 99%

The Effect of Epiretinal Membrane on the Treatment of Diabetic Macular Edema with Intravitreal Ranibizumab

Karaküçük¹

2019

Haydarpasa Numune Med J

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Introduction: This study aimed to compare the response to ranibizumab therapy in naive diabetic macular edema (DME) patients with and without an epiretinal membrane (ERM). Methods: A retrospective chart review was performed on 71 eyes in 71 DME patients. The patients were divided into a DME without ERM [ERM (-)] group (n=34) and DME with ERM [ERM (+)] group (n=37). Best-corrected visual acuity (BCVA), central macular thickness (CMT) and subfoveal choroidal thickness (SFCT) were evaluated. Results: There were no significant differences in age or gender distribution between the patients in the ERM (-) and ERM (+) groups (p=0.052, p=0.96, respectively). In both groups, CMT showed a significant decrease during the first, second and third months (p<0.01 for each in both groups). Therefore, BCVA increased in both groups and made significant gains from the second month (p=0.044 in the ERM (-) group and p=0.006 in the ERM (+) group). CMT and BCVA values did not differ significantly between the ERM (-) and ERM (+) groups in the baseline, first month, second month or third month. In the ERM (-) group, SFCT values decreased significantly as compared to baseline in the first month, second month and third month (p=0.001, p<0.001, p<0.001, respectively). In the ERM (+) group, the first month SFCT value did not change significantly (p=0.389), but it decreased significantly in the second month and third month as compared to baseline (p<0.001, p<0.001, respectively). Discussion and Conclusion: Based on studying patients for three months, we determined that a series of three monthly injections of ranibizumab ensured a statistically significant improvement in visual acuity and a decrease in CMT and SFCT in diabetic patients with or without ERM.

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Section: Discussionmentioning

confidence: 99%

The Effect of Epiretinal Membrane on the Treatment of Diabetic Macular Edema with Intravitreal Ranibizumab

Karaküçük¹

2019

Haydarpasa Numune Med J

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“…5 Ganglion cell complex thickness (GCCT) plays a particularly important role in visual function and assessment of the visual field and has been analyzed in numerous in vitro and in vivo studies in humans and animals. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] This study aimed to analyze the relationship between GCCT and vision compared with choroidal thickness (CT) and central retinal thickness (CRT) in relation to the outcomes of intravitreal aflibercept treatment for choroidal neovascular membranes secondary to AMD.…”

Section: Introductionmentioning

confidence: 99%

Relationship between ganglion cell complex thickness and vision in age-related macular degeneration treated with aflibercept

Buyukavsar

Sönmez

Sağdiç

et al. 2022

European Journal of Ophthalmology

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Purpose This study aimed to analyze the correlation between ganglion cell complex thickness (GCCT) and vision compared with the choroidal thickness (CT) and central retinal thickness (CRT) in relation to the outcomes of intravitreal aflibercept treatment for choroidal neovascular membranes secondary to age-related macular degeneration (AMD). Methods This was a prospective, observational study. Forty-three eyes of 38 patients with wet AMD received a monthly loading dose of 2 mg aflibercept by intravitreal injection (IVI) during the first 3 months and were then followed at regular monthly intervals for an average of 10 months by a pro re nata regimen. All patients were examined using spectral domain-optic coherence tomography (OCT) and enhanced depth imaging OCT. According to their response to IVI treatment in the third month, patients were divided into 2 groups, both functionally and anatomically. Results Three-month GCCT and optic disc retinal nerve fiber layer thickness (ODRNFLT) had the most correlation with the 10-month vision (p = 0.002, p = 0.02, respectively). While baseline GCCT was most correlated with the functional response, baseline CRT was most correlated with the anatomical response (p = 0.01, p = 0.004, respectively). Conclusions The results suggest that a reduction in 3-month GCCT indicates a good long-term vision outcome, while a reduction in 3-month ODRNFLT shows a poor long-term vision outcome. The literature suggests that this study is the first to demonstrate that baseline GCCT is more strongly correlated with the functional response than it is with CT and CRT. Hence, GCCT has a prognostic value for vision impairment.

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Long-term effects of intravitreal ranibizumab treatment on retinal ganglion cell complex and choroidal thickness

Abstract: Background: To evaluate the long-term effects of intravitreal ranibizumab treatment on both choroidal and retinal layers thicknesses using spectral domain optical coherence tomography (SD-OCT) and Enhanced Depth Imaging (EDI) mode.

Cited by 2 publications

References 24 publications

The Effect of Epiretinal Membrane on the Treatment of Diabetic Macular Edema with Intravitreal Ranibizumab

The Effect of Epiretinal Membrane on the Treatment of Diabetic Macular Edema with Intravitreal Ranibizumab

Relationship between ganglion cell complex thickness and vision in age-related macular degeneration treated with aflibercept

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