Long-term effects of nanoscaled titanium dioxide on the cladoceran Daphnia magna over six generations

Jacobasch, Claudia; Völker, Carolin; Giebner, Sabrina; Völker, Johannes; Alsenz, Heiko; Potouridis, Theodoros; Heidenreich, Heike; Kayser, Gernot; Oehlmann, Jörg; Oetken, Matthias

doi:10.1016/j.envpol.2013.12.008

Cited by 66 publications

(16 citation statements)

References 40 publications

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“…Ma et al (2012) demonstrated that phototoxicity of nano-TiO 2 increased between 2 to 4 times under simulated solar radiation, being D. magna 100 times more sensitive than fish Japanese medaka (Oryzias latipes). The effects of long-term exposure of cladoceran D. magna to nanoTiO 2 were studied over six generations showing that chronic exposure to 1.78 mg L − 1 of nano-TiO 2 resulted in 100% mortality (Jacobasch et al, 2014). A similar study in zebrafish (D. rerio) demonstrated that, after six months of exposure, nano-TiO 2 was bioaccumulated in brain, gill, liver and heart, producing organ injury and mortality (Chen et al, 2011).…”

Section: Concentrations and Toxicity Of Inorganic Uv-filters In The Ementioning

confidence: 98%

Are sunscreens a new environmental risk associated with coastal tourism?

Sánchez-Quiles

Tovar-Sánchez

2015

Environment International

201

131

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The world coastal-zone population and coastal tourism are expected to grow during this century. Associated with that, there will be an increase in the use of sunscreens and cosmetics with UV-filters in their formulation, which will make coastal regions worldwide susceptible to the impact of these cosmetics. Recent investigations indicate that organic and inorganic UV-filters, as well as many other components that are constituents of the sunscreens, reach the marine environment--directly as a consequence of water recreational activities and/or indirectly from wastewater treatment plants (WWTP) effluents. Toxicity of organic and inorganic UV filters has been demonstrated in aquatic organism. UV-filters inhibit growth in marine phytoplankton and tend to bioaccumulate in the food webs. These findings together with coastal tourism data records highlight the potential risk that the increasing use of these cosmetics would have in coastal marine areas. Nevertheless, future investigations into distribution, residence time, aging, partitioning and speciation of their main components and by-products in the water column, persistence, accumulation and toxicity in the trophic chain, are needed to understand the magnitude and real impact of these emerging pollutants in the marine system.

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Section: Concentrations and Toxicity Of Inorganic Uv-filters In The Ementioning

confidence: 98%

Are sunscreens a new environmental risk associated with coastal tourism?

Sánchez-Quiles

Tovar-Sánchez

2015

Environment International

201

131

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“…Ils dé crivent des anomalies morphologiques des follicules ainsi qu'une diminution du taux d'ovocytes matures dans les follicules exposé s par rapport aux contrô les non exposé s. Aprè s exposition in vivo de souris aux NPs de titane par voie orale, plusieurs é tudes [65,66] ont montré une biodistribution des NPs au niveau ovarien, une diminution de la fertilité et une augmentation du taux d'oestradiol et du nombre de follicules atré tiques. Sur un modè le de crustacé (Daphnia magna), Jacobasch et al [67] ont observé une diminution de la fertilité sur plusieurs gé né rations aprè s une exposition chronique aux NPs de titane.…”

Section: Effets Sur Les Cellules Gonadiques Fe´mininesunclassified

Reprotoxicité des nanoparticules

Greco

Courbière

Rose

et al. 2015

Gynécologie Obstétrique & Fertilité

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“…This paper focused on a detailed, empirically based model of the physiology and population dynamics of just one model organism, Daphnia. Daphnia represents an important genus in many temperate freshwater bodies, so our work has immediate applicability, exemplified by recent empirical work, where multigenerational life‐table experiments on Daphnia exposed to engineered nanoparticles (TiO 2 ) were used to calculate changes in long‐run population growth rate using the Euler‐Lotka equation (Jacobasch et al 2014). The data demands for such studies are huge, and fitting a validated bioenergetic model like ours will reduce the effort and cost required for similar future investigations.…”

Section: Discussionmentioning

confidence: 99%

Relating suborganismal processes to ecotoxicological and population level endpoints using a bioenergetic model

Ananthasubramaniam

McCauley

Gust

et al. 2015

Ecological Applications

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Ecological effects of environmental stressors are commonly evaluated using organismal or suborganismal data, such as standardized toxicity tests that characterize responses of individuals (e.g., mortality and reproduction) and a rapidly growing body of "omics" data. A key challenge for environmental risk assessment is relating such information to population dynamics. One approach uses dynamic energy budget (DEB) models that relate growth and reproduction of individuals to underlying flows of energy and elemental matter. We hypothesize that suborganismal information identifies DEB parameters that are most likely impacted by a particular stressor and that the DEB model can then project suborganismal effects on life history and population endpoints. We formulate and parameterize a model of growth and reproduction for the water flea Daphnia magna. Our model resembles previous generic bioenergetic models, but has explicit representation of discrete molts, an important feature of Daphnia life history. We test its ability to predict six endpoints commonly used in chronic toxicity studies in specified food environments. With just one adjustable parameter, the model successfully predicts growth and reproduction of individuals from a wide array of experiments performed in multiple laboratories using different clones of D. magna raised on different food sources. Fecundity is the most sensitive endpoint, and there is broad correlation between the sensitivities of fecundity and long-run growth rate, as is desirable for the default metric used in chronic toxicity tests. Under some assumptions, we can combine our DEB model with the Euler-Lotka equation to estimate longrun population growth rates at different food levels. A review of Daphnia gene-expression experiments on the effects of contaminant exposure reveals several connections to model parameters, in particular a general trend of increased transcript expression of genes involved in energy assimilation and utilization at concentrations affecting growth and reproduction. The sensitivity of fecundity to many model parameters was consistent with frequent generalized observations of decreased expression of genes involved in reproductive physiology, but interpretation of these observations requires further mechanistic modeling. We thus propose an approach based on generic DEB models incorporating few essential species-specific features for rapid extrapolation of ecotoxicogenomic assays for Daphnia-based population risk assessment.

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Long-term effects of nanoscaled titanium dioxide on the cladoceran Daphnia magna over six generations

Cited by 66 publications

References 40 publications

Are sunscreens a new environmental risk associated with coastal tourism?

Are sunscreens a new environmental risk associated with coastal tourism?

Reprotoxicité des nanoparticules

Relating suborganismal processes to ecotoxicological and population level endpoints using a bioenergetic model

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