Long-term effects of ovariectomy on pituitary-adrenal axis and specific antibody response in rats

Kuhn, G.; Waldherr, Rüdiger; Maser-Gluth, Christiane; Hardegg, W.; Vecsei, P.

doi:10.1007/bf02576688

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…Data from this study indicates that oestrogen is necessary for normal adrenal gland mass, zona glomerulosa area of the adrenal gland and corresponding aldosterone production during a stressor in mdx mice. These data are like that described in WT rodents, where ovariectomy lowers adrenal gland mass 29 , decreases adrenal cortex activity 30 and expands zona glomerulosa cells 30 . Oestradiol also increases aldosterone secretion in female rats 31 .…”

Section: Discussionsupporting

confidence: 79%

The unconditioned fear response in dystrophin-deficient mice is associated with adrenal and vascular function

Lindsay

Russell

2023

Sci Rep

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Loss of function mutations in the gene encoding dystrophin elicits a hypersensitive fear response in mice and humans. In the dystrophin-deficient mdx mouse, this behaviour is partially protected by oestrogen, but the mechanistic basis for this protection is unknown. Here, we show that female mdx mice remain normotensive during restraint stress compared to a hypotensive and hypertensive response in male mdx and male/female wildtype mice, respectively. Partial dystrophin expression in female mdx mice (heterozygous) also elicited a hypertensive response. Ovariectomized (OVX) female mdx mice were used to explain the normotensive response to stress. OVX lowered skeletal muscle mass and lowered the adrenal mass and zona glomerulosa area (aldosterone synthesis) in female mdx mice. During a restraint stress, OVX dampened aldosterone synthesis and lowered the corticosterone:11-dehydrocorticosterone. All OVX-induced changes were restored with replacement of oestradiol, except that oestradiol lowered the zona fasciculata area of the adrenal gland, dampened corticosterone synthesis but increased cortisol synthesis. These data suggest that oestrogen partially attenuates the unconditioned fear response in mdx mice via adrenal and vascular function. It also suggests that partial dystrophin restoration in a dystrophin-deficient vertebrate is an effective approach to develop an appropriate hypertensive response to stress.

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Section: Discussionsupporting

confidence: 79%

The unconditioned fear response in dystrophin-deficient mice is associated with adrenal and vascular function

Lindsay

Russell

2023

Sci Rep

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Interactions Between the Hypothalamic‐Pituitary‐Adrenal Axis and Immune System During Viral Infection: Pathways for Environmental Effects on Disease Expression

Miller

Pearce

Ruzek

et al. 2001

Comprehensive Physiology

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The sections in this article are: Immune Responses to Viral Infection Early Innate Immunity Late Adaptive Immunity Pathology During Viral Infection Cell‐Mediated Pathology Cytokine‐Mediated Pathology Cytokine Pathways for Glucocorticoid Induction During Viral Infection [“ Starting the Loop ”] Glucocorticoid Induction during Viral Infection Cytokines and Glucocorticoid Induction during Viral Infection Central Nervous System/Neuroendocrine Pathways for Glucocorticoid Induction During Viral Infection (“ Making the Connection ”) Pathways by which Peripheral Cytokine Signals Reach the Brain Cytokine Network in the Central Nervous System Cytokines and Behavior Viral Infection, Glucocorticoid Availability, and Glucocorticoid Receptor Expression and Function (“ Delivering and Receiving The Signal ”) Corticosteroid‐Binding Globulin and 11β‐Hydroxysteroid Dehydrogenase Glucocorticoid Receptor Changes during Viral Infection Cytokines as Potential Mediators of Glucocorticoid Receptor Changes during Viral Infection Endogenous Glucocorticoids and Host Responses to Viral Infection (“ Shaping The Response, Protection, and Closing the Loop ”) Impact of Stress on Immune Responses to Viral Infection Glucocorticoids as the Mediator of Stress Effects on Viral Immunity Summary

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The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions

McEwen

Biron

Brunson

et al. 1997

Brain Research Reviews

745

463

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Long-term effects of ovariectomy on pituitary-adrenal axis and specific antibody response in rats

Cited by 5 publications

References 17 publications

The unconditioned fear response in dystrophin-deficient mice is associated with adrenal and vascular function

The unconditioned fear response in dystrophin-deficient mice is associated with adrenal and vascular function

Interactions Between the Hypothalamic‐Pituitary‐Adrenal Axis and Immune System During Viral Infection: Pathways for Environmental Effects on Disease Expression

The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions

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