Long-term effects of pediatric adenotonsillectomy on serum immunoglobulin levels: results of a randomized controlled trial

Long-term follow-up of patients with IgA nephropathy treated with prednisolone and cyclophosphamide therapy

“…Serum immunoglobulin changes have been reported vigorously in relation to tonsil and adenoid surgery. Some authors observed a significant decrease in serum IgG levels after surgery [20], but a pattern of change in serum IgA levels was less consistent [21,22]. Moreover, we found a positive correlation between the serum IgA level and the degree of proteinuria.…”

Retropharyngeal and parapharyngeal abscesses or phlegmons in children

“…Similarly, Jeschke el al documented a progressive decrease in IgM, IgG and IgA levels during a 38-month period following tonsillectomy [5]. However, van den Akker et al showed that while children aged 4-8 years undergoing tonsillectomy had a greater decrease in IgA levels, children with tonsil disease who do not undergo surgical treatment have a decrease in their IgM and IgG levels comparable to those undergoing tonsillectomy [6]. Interestingly, the decrease in IgA levels in children undergoing tonsillectomy between 4 and 8 years old did not lead to an increased incidence of upper respiratory tract infections.…”

Clinical Factors Associated with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections

“…This finding may suggest that pre-existing infections such as otitis and pharyngitis were related to risk of developing neuropsychiatric symptoms (25, 26) or that removal of this lymphoid tissue increased immunologic risks (27, 28) that may be associated with increased risk of OCD/TS (5). Although symptomatic GAS infections have been shown to decrease after tonsillectomy (29), the role of non-carrier state subclinical infections has not been documented.…”