Long‐term effects of respiratory syncytial virus (RSV) bronchiolitis in infants and young children: a quantitative review

Kneyber, M. C. J.; Steyerberg, E.W.; Groot, Ronald de; Moll, HA

doi:10.1111/j.1651-2227.2000.tb00359.x

Cited by 113 publications

(57 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most children will have an RSV infection before 2 years of age [2]; however, certain high-risk groups are at an increased risk of severe RSV infection [3]. Prophylaxis (Palivizumab) can be given to high-risk groups including infants less than 12 months old at the beginning of RSV season who were born premature (earlier than 29 weeks gestation), infants with some congenital pulmonary and heart diseases, and immunocompromised infants [4].…”

Section: Introductionmentioning

confidence: 99%

Local variations in the timing of RSV epidemics

et al. 2016

View full text Add to dashboard Cite

BackgroundRespiratory syncytial virus (RSV) is a primary cause of hospitalizations in children worldwide. The timing of seasonal RSV epidemics needs to be known in order to administer prophylaxis to high-risk infants at the appropriate time.MethodsWe used data from the Connecticut State Inpatient Database to identify RSV hospitalizations based on ICD-9 diagnostic codes. Harmonic regression analyses were used to evaluate RSV epidemic timing at the county level and ZIP code levels. Linear regression was used to investigate associations between the socioeconomic status of a locality and RSV epidemic timing.Results9,740 hospitalizations coded as RSV occurred among children less than 2 years old between July 1, 1997 and June 30, 2013. The earliest ZIP code had a seasonal RSV epidemic that peaked, on average, 4.64 weeks earlier than the latest ZIP code. Earlier epidemic timing was significantly associated with demographic characteristics (higher population density and larger fraction of the population that was black).ConclusionsSeasonal RSV epidemics in Connecticut occurred earlier in areas that were more urban (higher population density and larger fraction of the population that was). These findings could be used to better time the administration of prophylaxis to high-risk infants.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-016-2004-2) contains supplementary material, which is available to authorized users.

show abstract

Section: Introductionmentioning

confidence: 99%

Local variations in the timing of RSV epidemics

et al. 2016

View full text Add to dashboard Cite

show abstract

“…A number of case-control studies appear to have established at least a statistical connection between RS virus infection in infancy and the development of recurrent wheezing and asthma in young children [3,4,5,6,7,8]. In later life, it appears unlikely to be a cause of atopic asthma [3,5,8]. On the other hand, rhinovirus infection is a major cause of acute exacerbation of asthma in both adults [9] and children [10].…”

Section: Introductionmentioning

confidence: 99%

Differential Effects of Corticosteroids on Serum Eosinophil Cationic Protein and Cytokine Production in Rhinovirus- and Respiratory Syncytial Virus-Induced Acute Exacerbation of Childhood Asthma

Katô

Yamada²,

Maruyama³

et al. 2011

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Little information is available on eosinophil activation and the cytokine profile in virus-induced acute exacerbation of bronchial asthma; therefore, we examined the effects of treatments that included systemic corticosteroids on serum eosinophil cationic protein (ECP) and 17 cytokines/chemokines in rhinovirus- and respiratory syncytial (RS) virus-induced acute exacerbation of childhood asthma. Methods: We measured the peripheral eosinophil count, as well as the serum levels of ECP and 17 types of cytokines/chemokines (IL-1β, 2, 4, 5, 6, 7, 8, 10, 12, 13, and 17 and IFN-γ, TNF-α, GM-CSF, G-CSF, MCP-1, and MIP-1β), using a multiplex bead-based assay in 21 cases of rhinovirus- and 12 cases of RS virus-induced acute exacerbation of childhood asthma and 13 controls. We also compared the clinical data and the effects of systemic corticosteroids on these responses between rhinovirus and RS virus groups. Results: The serum levels of ECP, IL-5, and IL-6 were significantly elevated in patients with rhinovirus-induced acute exacerbation of asthma compared with controls, while serum IL-1β and IFN-γ were significantly lower in patients with rhinovirus-induced acute exacerbation of asthma than in controls. On the other hand, in RS virus-induced acute exacerbation of asthma, only the peripheral eosinophil count was significantly decreased compared with that in rhinovirus-induced acute exacerbation of asthma and controls. Furthermore, the serum levels of ECP, IL-5, and IL-6 in rhinovirus-induced acute exacerbation of asthma and levels of G-CSF in RS virus-induced acute exacerbation of asthma were significantly reduced after treatments that included systemic corticosteroids, respectively. Conclusion: These results suggest that the effects of systemic corticosteroids on serum ECP and the cytokine profile are different between rhinovirus- and RS virus-induced acute exacerbation of childhood asthma.

show abstract

“…Recurrent wheezing is a common complication of severe RSV bronchiolitis in infancy Meta-analysis of longitudinal studies however suggests that the heightened risk of wheeze and/or asthma is abolished by the fifth year of follow up [31]. DNA methylation is discussed as a mechanism of gene-environment interplay in the pathogenesis of asthma [32].…”

Section: Discussionmentioning

confidence: 99%

Reduced PRF1 enhancer methylation in children with a history of severe RSV bronchiolitis in infancy: an association study

et al. 2017

View full text Add to dashboard Cite

BackgroundAcute lower respiratory tract infection is the commonest disease affecting children under five worldwide. Respiratory syncytial virus (RSV) is among the most common causative pathogens. Epidemiological data suggest an association between severe viral respiratory infections in infancy and increased incidence of childhood wheeze and asthma. DNA methylation is involved in immune cell differentiation and identity. It provides an avenue for environmental influences on the genome and therefore has potential as a marker for sustained effects of infectious insults. In this study we investigated the association between DNA methylation patterns in the perforin gene (PRF1) in childhood and a history of hospitalisation for severe RSV disease in the first two years of life.MethodsIn this retrospective study, we explored patterns of whole blood DNA methylation at a methylation sensitive region of the proximal PRF1 enhancer in a group of children with a record of hospitalisation for severe RSV disease during infancy (n = 43) compared to healthy controls matched for age and sex with no similar hospitalisation history, no allergy and no persistent wheeze (n = 43). Univariate and bivariate conditional logistic regression analyses were conducted to test the association between PRF1 enhancer methylation and record of hospitalisation for RSV disease.ResultsChildren with a record of hospitalisation for severe RSV bronchiolitis demonstrated markedly lower levels of DNA methylation at two cytosine-phosphate-guanine dinucleotide (CpG) loci of the PRF1 proximal enhancer, corresponding to a signal transducer and activator of transcription 5 (STAT5) responsive element, compared to controls, adjusted odds ratios of 0.82 (95% confidence interval [CI] 0.71, 0.94) and 0.73 (95% CI 0.58, 0.92) for each 1% increase in DNA methylation. Smoking in the household showed a significant influence on DNA methylation at the assayed positions.ConclusionsOur findings support an association between childhood DNA methylation patterns in PRF1 and a record of severe RSV infection in infancy. Longitudinal studies are required to establish the utility of PRF1 methylation as a marker of severe RSV disease.

show abstract

Long‐term effects of respiratory syncytial virus (RSV) bronchiolitis in infants and young children: a quantitative review

Cited by 113 publications

References 30 publications

Local variations in the timing of RSV epidemics

Local variations in the timing of RSV epidemics

Differential Effects of Corticosteroids on Serum Eosinophil Cationic Protein and Cytokine Production in Rhinovirus- and Respiratory Syncytial Virus-Induced Acute Exacerbation of Childhood Asthma

Reduced PRF1 enhancer methylation in children with a history of severe RSV bronchiolitis in infancy: an association study

Contact Info

Product

Resources

About