“…[CI]: 0.033-0.753) to 0.568 (95% CI: 0.175-0.961) when the studies of Wu 2001 (36) and Felekis 2010 (39) were omitted. After five studies were removed, in which means and SDs were extracted by reading the graphs or calculating the medians and interquartile ranges (35,42,45,47,50) , a significant decrease in IL-6 was observed (SMD, 0.573; 95% CI: 0.092-1.053), and the heterogeneity remained significant (P heterogeneity < 0.001; I 2 = 90.5%). Additional analysis by including two non-RCTs (29,30) showed a similar result in IL-6 after omega-3 PUFA administration (SMD, 0.975; 95% CI: 0.386-1.564) with significant heterogeneity (P heterogeneity < 0.001; I 2 = 94.7%).…”