Long-Term Effects on Cortical Excitability and Motor Recovery Induced by Repeated Muscle Vibration in Chronic Stroke Patients

Marconi, Barbara; Filippi, Guido Maria; Koch, Giacomo; Giacobbe, V.; Pecchioli, Cristiano; Versace, Viviana; Camerota, Filippo; Saraceni, Vincenzo Maria; Caltagirone, Carlo

doi:10.1177/1545968310376757

Cited by 156 publications

(178 citation statements)

References 53 publications

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“…As a general finding, the stroke severity correlated with the CSE on the AH: the more severe the stroke, the less excitable the corticospinal tract. Earlier, the severity of stroke has been found to be closely related to the modulation of CSE, not only with the acute stage functional impairment but with the clinical outcome [18,31]. In the present study the FAC 6mo correlated with acute stage CSE on the AH.…”

Section: Discussionsupporting

confidence: 62%

Longitudinal study on modulated corticospinal excitability throughout recovery in supratentorial stroke

Julkunen

Könönen

Määttä

et al. 2016

Neuroscience Letters

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Longitudinal study on modulated corticospinal excitability throughout recovery in supratentorial stroke, Neuroscience Letters http://dx.doi.org/10. 1016/j.neulet.2016.02.014 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractCorticospinal excitability (CSE) is modulated by stroke-induced lesions affecting the brain. This modulation is known to be dependent on the timing of the evaluation, and strongest abnormalities are often found in the acute stage. Our study aimed to characterize changes in CSE asymmetry between the affected and the unaffected hemisphere (AH and UH) during the first month after stroke onset and at 6 month follow-up. Neuronavigated transcranial magnetic stimulation (nTMS) was used to assess the CSE of the abductor pollicis brevis (APB) muscle of the hand and tibialis anterior (TA) muscle of the leg in 16 patients over 5 time-points. AH excitability recovered significantly during 6 months, whereas interhemispheric asymmetry remained significant up to 1 month post-stroke in the APB muscle. Greater initial CSE was associated with good motor function at 6 months. The motor cortical excitatory recovery initiated within week of the stroke and was most prominent within 1 month after stroke onset. Lesion size correlated with CSE of the UH at 10 days, while overall severity of the symptoms correlated inversely with CSE of the AH. This study demonstrates the quick improvement in the CSE via estimation of interhemispheric asymmetry; however, the recovery in the asymmetry continues to normalize even after reaching the threshold for normal values in CSE.

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Section: Discussionsupporting

confidence: 62%

Longitudinal study on modulated corticospinal excitability throughout recovery in supratentorial stroke

Julkunen

Könönen

Määttä

et al. 2016

Neuroscience Letters

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“…While other vibration paradigms have demonstrated efficacy such as repeated flexor carpi radialis and biceps brachii vibration in neurorehabilitation and motor recovery in stroke patients (Marconi et al 2011), further investigations must now focus on the effects on corticospinal excitability with chronic Achilles tendon vibration. For instance, long-term potentiation of corticospinal excitability would be beneficial in rehabilitation as a countermeasure to the reduced neural drive observed in early stages of immobilization (Duchateau 1995;Gondin et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Achilles tendon vibration-induced changes in plantar flexor corticospinal excitability

et al. 2014

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Daily Achilles tendon vibration has been shown to increase muscle force, likely via corticospinal neural adaptations. The aim of the present study was to determine the extent by which corticospinal excitability is influenced during direct Achilles tendon vibration. Motor-evoked potentials (MEPs) were elicited in the soleus (SOL), gastrocnemius medialis (GM) and tibialis anterior (TA) by transcranial magnetic stimulation of the motor cortical area of the leg with and without Achilles tendon vibration at various frequencies (50, 80 and 110 Hz). Contralateral homologues were also investigated. SOL and GM MEP amplitude significantly increased by 226 ± 188 and 66 ± 39%, respectively, during Achilles tendon vibration, without any difference between the tested frequencies. No MEP changes were reported for TA or contralateral homologues. Increased SOL and GM MEP amplitude suggests increased vibration-induced corticospinal excitability independent of vibration frequency.

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“…Marconi et al reported that long-term application of vibratory stimulation to stroke patients with upper limb spasticity resulted in spasticity decrease and motor map areas increase, and emphasized the importance of long-term stimulation 10) . In the present study, tissue compliance at relaxation showed significant increases in 3 steps from 0.75 kg to 1.25 kg immediately after vibratory stimulation, and in 5 steps from 0.5 kg to 1.5 kg after vibratory stimulation for three weeks, indicating the importance of long-term stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…The subjects were recruited from among those who were at least six months after the onset of stroke, were grade 2 on the MAS, on which they showed a noticeable increase in spasticity but could move their elbow joint 10) , had no pathological findings in the musculoskeletal system of the elbow, could understand and follow the directions of the experimenter, and had no history of treatment with botulinum toxin, phenol, or alcohol injections. Each subject voluntarily consented to participation in this study.…”

Section: Subjectsmentioning

confidence: 99%

The Effect of Vibratory Stimulation on Tissue Compliance and Muscle Activity in Elbow Flexor Spasticity

Bae¹,

Kim

2012

J Phys Ther Sci

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Abstract. [Purpose] This study investigated the effect of vibratory stimulation on tissue compliance and muscle activity in stroke patients with elbow flexor spasticity. [Subjects and Methods] Twenty patients who were grade 2 on the Modified Ashworth Scale (MAS) were evaluated before and after vibratory stimulation. This evaluation was done using MAS (change of clinical characteristic), a myotonometer (change in muscle tissue compliance), and surface electromyography (sEMG) (change in muscle activity).[Results] MAS results showed significant decreases immediately and three weeks after the start of vibratory stimulation. Tissue compliance significantly increased immediately (0.75, 1, and 1.25 kg) and three weeks (0.5, 0.75, 1, 1.25, and 1.5 kg) after the start of vibratory stimulation, and muscle tone decreased. Muscle activity significantly increased immediately (1 and 1.25 kg) and three weeks (0.75, 1, 1.25, and 1.5 kg) after the start of vibratory stimulation.[Conclusion] Using a myotonometer and sEMG, we demonstrated that vibratory stimulation was an effective form of therapeutic stimulation. Vibratory stimulation can be used as a non-pharmacological therapy for the neurorehabilitation of patients with spasticity.

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Long-Term Effects on Cortical Excitability and Motor Recovery Induced by Repeated Muscle Vibration in Chronic Stroke Patients

Abstract: rMV with PT may be used as a nonpharmacological intervention in the neurorehabilitation of mild to moderate hemiparesis.

Cited by 156 publications

References 53 publications

Longitudinal study on modulated corticospinal excitability throughout recovery in supratentorial stroke

Longitudinal study on modulated corticospinal excitability throughout recovery in supratentorial stroke

Achilles tendon vibration-induced changes in plantar flexor corticospinal excitability

The Effect of Vibratory Stimulation on Tissue Compliance and Muscle Activity in Elbow Flexor Spasticity

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